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191.
A failure-time distribution made up of two exponential distributions having two distinct failure rates and a specific mixture proportion is considered. The associated experiment is terminated after a predetermined time has elapsed and the numbers of failures in each time interval are recorded. As soon as an item fails it can be attributed to the appropriate subpopulation. An empirical procedure is proposed to estimate the 3 parameters of the model. The maximum likelihood estimators and our estimators are compared using both real and simulated data. The procedure can be extended to a mixed model of three or more exponential distributions, and can be applied to ungrouped and/or uncensored samples. 相似文献
192.
BACKGROUND: Steroid 5 alpha-reductase is implicated in the pathogenesis of benign prostatic hyperplasia (BPH). We studied the in vitro and in vivo effects of FR146687, a new inhibitor of 5 alpha-reductase. METHODS: Two isozymes of rat and human 5 alpha-reductases were expressed in 293 cells. In vivo effects of drugs were evaluated on rat and dog prostates. Castrated immature rats were injected with testosterone propionate (TP) or 5 alpha-dihydrotestosterone propionate (DHTP) to induce growth of the ventral prostates. Testosterone and 5 alpha-dihydrotestosterone (DHT) contents in rat and dog prostates were measured by gas chromatography-mass spectrophotometry (GC-MS). RESULTS: FR146687 showed noncompetitive inhibition in both isozymes and no inhibitory effects on other steroid oxidoreductases. In mature rats and castrated immature rats treated with TP, FR146687 dose-dependently reduced ventral prostate and seminal vesicle weight at doses above 0.1 mg/kg, while castrated immature rats treated with DHTP were not affected by FR146687. FR146687 showed more potent reduction of rat prostates than finasteride. DHT concentration in the prostates was significantly reduced when FR146687 was administered to rats and beagles. CONCLUSIONS: FR146687 is a dual inhibitor for 5 alpha-reductase isozymes and significantly reduced the growth and DHT content in the prostate. 相似文献
193.
Studies were made on the longitudinal ultrasonic velocity and its attenuation characteristics in medium carbon steel forging subjected to 0–60% hot upsetting followed by heat treatment. The fineness of ferrite and pearlite increased with increasing deformation and cooling rate during heat treatment. The area fraction of pearlite increased from 21% to 45% as well as the mean interlamellar spacing in pearlite decreased from 8.79 μm to 0.689 μm in the 40% deformed (upsetted) normalized sample It was observed that the ultrasonic velocity decreased with increasing degree of deformation. The velocity was found to be highest in the normalized steel acquiring a value of 5920 m/s and lowest in hardened steel acquiring a value of 4979 m/s. The attenuation decreased with increasing deformation resulting in increased back wall echo heights. The residual stresses on the surface of typical 60% deformed and annealed steel samples using x-ray diffractometry were measured to be — 39.7 MPa (compressive) and — 188.0 MPa (compressive) respectively. 相似文献
194.
Use of the singular value decomposition is suggested for problems of linear least-squares system identification rather than the usual method involving the normal equations. 相似文献
195.
R. K. Gupta M. K. Karthikeyan D. N. Bhalia B. R. Ghosh P. P. Sinha 《Metal Science and Heat Treatment》2008,50(3-4):175-179
A cobalt-base refractory alloy containing W, Ni, and Cr, which is widely used for making spacecraft components operating at high temperatures, is studied. Changes in the microstructure of the alloy are studied depending on the heat treatment, and the effect of these changes on mechanical properties at room and high temperatures is determined. 相似文献
196.
Ron Adams B.S. Uday Sinha Ph.D. 《JOM Journal of the Minerals, Metals and Materials Society》1990,42(5):31-34
Southwire continuous rod technology has been used for approximately a quarter of a century to produce high-quality copper rod, and ongoing modifications to the process have improved not only the copper product, but the actual efficiency of the production system. Some of these developments have been achieved through automatic quality monitoring and the application of sophisticated control devices. 相似文献
197.
Recently, we reported the isolation, cloning, and expression of a rat enzyme, fatty acid amide hydrolase (FAAH), that degrades bioactive fatty acid amides like oleamide and anandamide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Here, we report the molecular characterization of both a mouse and a human FAAH and compare these enzymes to the rat FAAH. The enzymes are well conserved in primary structure, with the mouse and rat FAAHs sharing 91% amino acid identity and the human FAAH sharing 82% and 84% identity with the rat FAAH and mouse FAAH, respectively. In addition, the expressed human and rat FAAHs behave biochemically as membrane proteins of comparable molecular size and show similar, but distinguishable, enzymological properties. The identification of highly homologous FAAH proteins in rat, mouse, and human supports a general role for the fatty acid amides in mammalian biology. 相似文献
198.
This paper presents the theory and performance of a differential induction machine, which is a special type of induction machine
having two shafts projected from the two ends of a single stator. Application of a differential load on the two shafts cause
them to run at different speed as a motor, which permits true differential movement and thus can meet the requirements of
a differential drive in an electric vehicle. The machine is also capable of regeneration in the differential mode. This paper
presents the construction of the above machine and performance of the same based on experimental results from a laboratory
prototype. The equivalent circuit of the motor has been presented and verified experimentally. 相似文献
199.
200.