Polymer electrolyte membranes derived from novel fluorine-containing poly(arylene ether ketone)s by controlled post-sulfonation

Precise assignment with ¹H, ¹³C and some two dimensional NMR measurements showed that sulfonation reaction by concentrated sulfuric acid at 30 °C of fluorine-containing poly(arylene ether ketone) copolymers derived from 4,4′-bis(2,4,5,6-pentafluorobenzoyl)diphenyl ether (BPDE) and 9,9-bis(4-hydroxypehnyl)fluorene (HF) and 2,2-bis(4-hydroxyphenyl)-1,1,1,3,3,3-hexafluoropropane (6FBA) yielded quantitative introduction of sulfonic groups onto 2- and 7-positions of fluorene ring in HF unit. A series of sulfonated poly(arylene ether ketone)s with different ion exchange capacity was prepared by using this method with different compositions of HF and 6FBA, and membranes obtained from these polymers were characterized by TGA, moisture and water uptake, proton conductivity, methanol permeability, and Fenton testing. These membranes showed sufficient thermal stability, high proton conductivity at high humidified condition for PEFC and good balance in proton conductivity in water and methanol permeability for DMFC. On the other hand, they showed relatively high swelling by water probably due to weak intermolecular interaction caused by the existence of fluorine atoms in the polymer structure.     

The influence of forest management on landscape structure in the cool-temperate forest region of central Japan

Comprehension of historical changes in landscape and forest management will provide valuable insights into current ecosystems and biodiversity and will support future management decisions and conservation strategies. This study clarified changes in the forest landscape of the cool-temperate forest region of central Japan from 1947 to 1997. We used a geographic information system to reconstruct past forest landscapes at four times (1947, 1962, 1975, and 1997) based on interpretation of aerial photographs and landscape metrics calculated using the FRAGSTATS software for spatial pattern analysis. Our results showed that secondary forests, the dominant land use in 1947, decreased greatly in area and became more fragmented, whereas coniferous plantations, which occupied approximately 20% of the total land area in 1947, became the dominant land use (almost 40% of the total land) by 1997. The young coniferous plantations have been established at increasing elevations over time and were mainly created by conversion of secondary forest until 1975. The number of young coniferous plantations and their patch spacing depended on the type of forest management. In the study area, landscape structure changed in response to changes in management of national forests, especially the expansion of afforestation in the 1950s and 1960s and changes in harvesting systems.     

The Role of Leaky Gut in Nonalcoholic Fatty Liver Disease: A Novel Therapeutic Target

The liver directly accepts blood from the gut and is, therefore, exposed to intestinal bacteria. Recent studies have demonstrated a relationship between gut bacteria and nonalcoholic fatty liver disease (NAFLD). Approximately 10–20% of NAFLD patients develop nonalcoholic steatohepatitis (NASH), and endotoxins produced by Gram-negative bacilli may be involved in NAFLD pathogenesis. NAFLD hyperendotoxicemia has intestinal and hepatic factors. The intestinal factors include impaired intestinal barrier function (leaky gut syndrome) and dysbiosis due to increased abundance of ethanol-producing bacteria, which can change endogenous alcohol concentrations. The hepatic factors include hyperleptinemia, which is associated with an excessive response to endotoxins, leading to intrahepatic inflammation and fibrosis. Clinically, the relationship between gut bacteria and NAFLD has been targeted in some randomized controlled trials of probiotics and other agents, but the results have been inconsistent. A recent randomized, placebo-controlled study explored the utility of lubiprostone, a treatment for constipation, in restoring intestinal barrier function and improving the outcomes of NAFLD patients, marking a new phase in the development of novel therapies targeting the intestinal barrier. This review summarizes recent data from studies in animal models and randomized clinical trials on the role of the gut–liver axis in NAFLD pathogenesis and progression.     

Novel ion conductive matrix via dehydrocoupling polymerization of imidazolium-type ionic liquid and lithium 9-borabicyclo[3,3,1]nonane hydride

Summary An ion conductive zwitterionic polymer electrolyte containing borate units was prepared. The polymer was synthesized via dehydrocoupling of lithium 9-borabicyclo[3,3,1]nonane hydride (lithium 9-BBN hydride) with 1,3-dihydroxyethylimidazolium bromide and subsequent anion exchange reaction using lithium bis(trifluoromethylsulfonyl)imide (LiTFSI). The obtained polymer showed the ionic conductivity of 3.4×10^-6 Scm^-1 at 50 °C in spite of relatively high glass transition temperature (-6 °C).