Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLCγ1 Signal Transduction Pathway

Erythroid differentiation regulator 1 (Erdr1) has previously been reported to control thymocyte selection via TCR signal regulation, but the effect of Erdr1 as a TCR signaling modulator was not studied in peripheral T cells. In this report, it was determined whether Erdr1 affected TCR signaling strength in CD4 T cells. Results revealed that Erdr1 significantly enhanced the anti-TCR antibody-mediated activation and proliferation of T cells while failing to activate T cells in the absence of TCR stimulation. In addition, Erdr1 amplified Ca²⁺ influx and the phosphorylation of PLCγ1 in CD4 T cells with the TCR stimuli. Furthermore, NFAT1 translocation into nuclei in CD4 T cells was also significantly promoted by Erdr1 in the presence of TCR stimulation. Taken together, our results indicate that Erdr1 positively modulates TCR signaling strength via enhancing the PLCγ1/Ca²⁺/NFAT1 signal transduction pathway.     

Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis

Rosacea is a common chronic cutaneous inflammatory disorder. Recently, patients with rosacea were identified as having a higher risk of developing various comorbidities such as cardiovascular disease, psychiatric disorders, neurologic disorders, and gastrointestinal disorders. However, the risks of some comorbidities in patients with rosacea are somewhat contradictory, depending upon the study design. Moreover, pathomechanisms associated with the comorbidities of patients with rosacea remain poorly elucidated. The purpose of this review was to provide the most up-to-date evidence on the risks of neuropsychiatric and gastrointestinal comorbidities in patients with rosacea. Moreover, the molecular pathomechanisms associated with neuropsychiatric and gastrointestinal comorbidities in patients with rosacea were evaluated based on recent studies. This review was also intended to focus more on the role of the gut–brain–skin axis in the association of neuropsychiatric and gastrointestinal comorbidities in rosacea.     

Effect of Amine Additive for the Synthesis of Cadmium Selenide Quantum Dots in a Microreactor

The effect of octylamine flow rate on the structure and morphology of CdSe quantum dots synthesized in a microreactor was studied. The flow rate of octylamine was varied from 0.005 ml/min to 0.030 ml/min, and the optical properties of the synthesized particles were analyzed by UV–vis and photoluminescence spectroscopy. The particle size of the quantum dots was found to increase with an increasing octylamine flow rate. Further, UV–vis and photoluminescence bands were found to be red‐shifted with an increasing flow rate. We determined that, by controlling octylamine flow rate, the particle size of the quantum dots could be controlled. This method will help to determine the optimal octylamine flow conditions for synthesizing nanoparticles for use in a diverse range of applications.     

Near‐infrared‐active and pH‐responsive fluorescent polymer‐integrated hybrid graphene oxide nanoparticles for the detection and treatment of cancer

Hybrid nanoparticles for theragnosis have great potentiality to bring desire functionalities in one integrated system. The development of bioimaging guided photothermal therapy (PTT) is pivotal in optimizing cytotoxic cancer therapy. We report near‐infrared (NIR)‐active and pH‐responsive fluorescent, catechol‐conjugated, reduced graphene oxide (rGO)‐anchored hybrid nanoparticles that can sharply increase the photothermal heat in response to NIR exposure and exhibit pH‐dependent fluorescence emission for the detection of tumor areas without causing cell toxicity. The optoelectronic absorption property of poly(3,4‐ethylenedioxythiophene) [PEDOT]:dopamine‐conjugated poly(4‐styrenesulfonate‐co‐maleic acid) [D‐PSM] and 3′,4′‐dihydroxyacetophenone/boron‐dipyrromethene [CCDP/BODIPY]‐quaternized polyethylene glycol grafted poly(dimethylaminoethyl methacrylate) (C/B‐PgP) present in this hybrid nanoparticles resulted in efficient photothermal conversion with pH‐tunable fluorescence that exerted sufficient photothermal cytotoxicity to cancer cells. The in vitro cellular uptake was measured by confocal laser scanning microscopy, allowing the therapeutic efficiency and bioimaging effects to be explored. We expect that the broad optical absorption property of PEDOT:D‐PSM with BODIPY‐conjugated polymers on rGO sheets would get tremendous attraction in this enormous rising PTT with cancer detectable biomarker. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43791.     

Correlation between the Izumiyama porcelain ceramics and the red-overglaze enamels of the Kakiemon-style porcelains

The Kakiemon-style porcelains made from 17th century at Arita are famous Japanese porcelains, characterized mainly by their colored underglaze and overglaze and by their original design of coloring spatial patterns in the porcelain surface. Raw materials of the red-overglaze enamels have been investigated by means of X-ray diffraction and X-ray absorption spectra using synchrotron radiations. It is found that Izumiyama porcelain ceramics of yellow color can produce the Kakiemon red-overglaze enamels by thermal treatment and water-washing, where Izumiyama is a collecting place of the raw porcelain ceramic at Arita. The brightness of the red-overglaze enamels is related on the local structure around Fe ions and the electronic band states of Fe ions near a Fermi level in α-Fe₂O₃, in addition to the spatial density of the α-Fe₂O₃ fine particles. The structural and electronic properties are slightly affected by an electron-hybridization between Fe ions of α-Fe₂O₃ and oxygen ions of the (SiO₂–Al₂O₃) complexes in the red overglaze.     

Effect of alumina nanoparticles in the fluid on heat transfer in double-pipe heat exchanger system

This study was performed to investigate the convective heat transfer coefficient of nanofluids made of several alumina nanoparticles and transformer oil which flow through a double pipe heat exchanger system in the laminar flow regime. The nanofluids exhibited a considerable increase of heat transfer coefficients. Although the thermal conductivity of alumina is not high, it is much higher than that of the base fluids. The nanofluids tested displayed good thermal properties. One of the possible reasons for the enhancement on heat transfer of nanofluids can be explained by the high concentration of nanoparticles in the thermal boundary layer at the wall side through the migration of nanoparticles. To understand the enhancement of heat transfer of nanofluid, an experimental correlation was proposed for an alumina-transformer oil nanofluid system.     

Pressure fluctuation properties in combustion of mixture of anthracite and bituminous coal in a fluidized bed

The combustion characteristics of a mixture of anthracite and bituminous coal were studied in a 0.155 m i.d. fluidized bed combustor (FBC). The properties of the pressure fluctuation for the bed such as the standard deviation, cross-correlation function, dominant frequency and the power spectral density function were obtained through statistical analysis. To interpret the combustion characteristics in the FBC with uniform or multi-sized particles of anthracitebituminous coal mixture, the properties of pressure fluctuation were determined as a function of the particle size distribution and anthracite mixing fraction. In the present work, it is known that the combustion region could be obtained from the analysis of pressure fluctuation properties, and the mixed-firing of anthracite-bituminous coal is related to the reaction models of both coals and particle size distribution. Moreover, the relation between coal size distribution and static mean pressure, and the ignition region could be obtained from the mean pressure profile.     

Synthesis and characterization of fluorescein isothiocyanate (FITC)-labeled PEO-PCL-PEO triblock copolymers for topical delivery

We present the synthesis of fluorescein isothiocyanate (FITC)-labeled poly(ethylene oxide)-block-poly(?-caprolactone)-block-poly(ethylene oxide) (PEO-PCL-PEO) triblock copolymers and their applications for tracking the penetration behavior of FITC-labeled copolymers in the hairless mouse skin. In the first step, PEO-PCL diblock copolymers with different ratios of PCL to PEO (i.e., [CL]/[EO]) were prepared by ring opening polymerization of ?-caprolactone (CL), where monomethoxy poly(ethylene glycol) (mPEG, M_n = 2000 g mol⁻¹) was used as a macro-initiator. FITC was successively reacted with octadecylamine, isophorone diisocyanate (IPDI), and then used as a linker to obtain PEO-PCL-PEO triblock copolymers from the PEO-PCL diblock copolymers. In aqueous solution, both FITC-labeled triblock copolymers show two UV absorption peaks at 489 and 455 nm, attributed to the monomeric FITC and H-aggregated FITC moieties, respectively. Due to the strong H-aggregation of FITC in the copolymer of high [CL]/[EO], fluorescent emission intensities considerably decreased at high concentrations of the copolymer. FITC-labeled copolymers exhibited more sharper polarized optical and fluorescence microscopic images compared to the mixtures of FITC and unlabeled copolymer in both solid crystalline and multiple emulsion state. Furthermore, the Frantz diffusion cell test was carried out to demonstrate the penetration behavior of the FITC-labeled copolymers in the hairless mouse skin.     

应用覆膜支架介入救治颈动脉破裂并假性动脉瘤

目的探讨应用覆膜支架介入治疗颈动脉破裂并假性动脉瘤.方法4例肿瘤所致颈动脉破裂并假性动脉瘤形成的患者,均出现颈部或口腔危及生命的出血,采用Seldinger方法,选用自膨式聚四氟乙烯覆膜支架治疗.结果4例成功施行血管内介入治疗,其中颈总动脉中段1例,颈动脉球2例,颈总动脉远段1例.共置入覆膜支架6枚.术后假性动脉瘤腔被隔绝,颈动脉通畅,患者的临床症状明显改善,无神经功能障碍.1例患者11 d后支架下缘颈总动脉与原瘤腔相通,再次置入覆膜支架,2个月的随访无再出血.1例患者经钢圈栓塞、放置覆膜支架及裸支架瘤腔     

First dicadmium(II) complex of tripodal amide ligand with one edge-sharing monocapped octahedral geometry

A new dicadmium(II) complex [Cd₂(L)₂(H₂O)₂](NO₃)₄ · 8H₂O (1) with the tripodal amide ligand L (tris[3-aza-2-oxo-4-(2-pyridyl)butyl]amine) was synthesized and structurally characterized. Complex 1 is revealed as a dinuclear 2:2 (Cd:L) complex, in which each cadmium(II) ion is hepta-coordinated with the coordination surrounding of distorted monocapped octahedral geometry. Two cadmium(II) ions are dibridged by two carbonyl μ-O atoms forming a Cd₂(μ-O)₂ parallelogram-type moiety. Interestingly, the dinuclear coordination sphere can be seen as resulting from the fusion of two distorted monocapped octahedral [Cd(L)(H₂O)]²⁺ units through sharing one edge originated from the two carbonyl μ-O atoms as a first example. Comparative NMR, IR and FAB-mass data of 1 are also discussed.