Quantitative electroencephalographic profiles for children with autistic spectrum disorder.

The present study examined quantitative electroencephalographic (QEEG) profile for children with autistic spectrum disorder (ASD). Five-minute QEEG data were obtained from 90 normal controls (NCs) and 66 children with ASD. Spectrum analyses revealed that ASD children showed significantly less relative alpha and more relative delta than NC. Specifically, 26% of ASD children and 2% of NCs showed 1.5 SDs of relative alpha below the normative mean. Children with this QEEG profile had 17 times the risk of having ASD than those without such a profile. Sensitivity and specificity of relative alpha were 91% and 73%, respectively. Split-half cross-validation yielded a sensitivity of 76%. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration

The challenge of developing gene therapies for genetic forms of blindness is heightened by the heterogeneity of these conditions. However, mechanistic commonalities indicate key pathways that may be targeted in a gene-independent approach. Mitochondrial dysfunction and axon degeneration are common features of many neurodegenerative conditions including retinal degenerations. Here we explore the neuroprotective effect afforded by the absence of sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1), a prodegenerative NADase, in a rotenone-induced mouse model of retinal ganglion cell loss and visual dysfunction. Sarm1 knockout mice retain visual function after rotenone insult, displaying preservation of photopic negative response following rotenone treatment in addition to significantly higher optokinetic response measurements than wild type mice following rotenone. Protection of spatial vision is sustained over time in both sexes and is accompanied by increased RGC survival and additionally preservation of axonal density in optic nerves of Sarm1^−/− mice insulted with rotenone. Primary fibroblasts extracted from Sarm1^−/− mice demonstrate an increased oxygen consumption rate relative to those from wild type mice, with significantly higher basal, maximal and spare respiratory capacity. Collectively, our data indicate that Sarm1 ablation increases mitochondrial bioenergetics and confers histological and functional protection in vivo in the mouse retina against mitochondrial dysfunction, a hallmark of many neurodegenerative conditions including a variety of ocular disorders.     

Energy efficiency actions related to the rollout of smart meters for small consumers, application to the Austrian system

Smart meters (SM) may provide large benefits to all stakeholders by providing the information required to implement certain sets of demand response actions. Benefits produced by SM related actions depend on the features of these actions, the system and the targeted consumer group.We first lay out an analytical framework to analyze the application of Demand Response (DR) actions. Based on this framework, we describe a way to determine the response of domestic load in a system to the implementation of DR actions. We propose determining the overall change in the consumption behavior of domestic load based on previously obtained estimates of the peak load and overall consumption reduction for different types of consumers in different types of systems resulting from the application of each set of actions. We have carried out a comprehensive literature review to provide here such estimates.We apply the analytical framework and methodology developed to characterize the reaction of consumers in the Austrian system to different SM related actions. Finally, we provide guidelines on which DR actions to implement in this system and how to implement them. The use of advanced indirect feedback on consumption behavior, critical peak prices and simple time-of-use tariffs is advocated.     

Correction to: Classifying MOOC forum posts using corpora semantic similarities: a study on transferability across different courses

Neural Computing and Applications - A correction to this paper has been published: https://doi.org/10.1007/s00521-021-05904-z     

Amphiphilic four-helix bundle peptides designed for light-induced electron transfer across a soft interface

A family of four-helix bundle peptides were designed to be amphiphilic, possessing distinct hydrophilic and hydrophobic domains along the length of the bundle's exterior. This facilitates their vectorial insertion across a soft interface between polar and nonpolar media. Their design also now provides for selective incorporation of electron donor and acceptor cofactors within each domain. This allows translation of the designed intramolecular electron transfer along the bundle axis into a macroscopic charge separation across the interface.     

Can Addresses be Types?: A case study: objects with delegation

We adapt the aliasing constraints approach for designing a flexible typing of evolving objects. Types are singleton types (addresses of objects, as a matter of fact) whose relevance is mainly due to the sort of safety property they guarantee. In particular we provide a type system for an imperative object based calculus with delegation and which supports method and delegate overriding, addition, and removal.