Design criterion for zero-input asymptotic overflow-stability of recursive digital filters in the presence of quantization

This paper investigates the zero-input stability properties of the exact second-order recursive digital filter having both overflow and quantization non-linearities. Two examples demonstrate the adverse influence of quantization on the overflow-stability property of the filter. Three sets of conditions are presented to ensure asymptotic overflow-stability in the presence of quantization. Using these criteria, various regions in the coefficient plane corresponding to different minimum internal wordlengths required to ensure the non-interaction of overflow and quantization are derived. These results thus form a useful design criterion.This work was supported in part by a Monash Graduate Scholarship (awarded to P.K. Sim) and Telecom Australia under Contract No. 64514.     

Phytochemical evaluation of essential oils, medicinal plants and their preparations

The central objectives of GLAS are (a) to study the associations between pathology--and related impairments and disability--on the one hand, and well-being and utilization of care among older people on the other, and (b) how these associations are affected by person-bound and environmental factors. The present paper describes the main research questions, the design and some preliminary results of GLAS. In addition, an explanatory model for well-being, derived from the theory of social-production functions (spf) is elaborated. Two major conclusions can be drawn from these results. (1) The hypotheses derived from spf are mainly supported by the results of several substudies of GLAS. (2) The cross-sectional analyses showed main effects of psychological attributes--independent of pathology and impairments--on disability and well-being; we hardly found any empirical support for the hypothesized moderating effects of psychological attributes on the associations between these concepts. We conclude with some suggestions for future research.     

Apolipoprotein AI-CIII, B, and CII gene polymorphisms in patients with non-insulin dependent diabetes mellitus. Association with hyperlipemia

BACKGROUND: Dislipidaemia is an usual feature in patients affected by non insulin dependent diabetes mellitus. Several studies show that this disease could be genetically determined. The aim of this study was to ascertain whether any of the genetic polymorphism remaining in three apolipoprotein loci (apolipoprotein AI-CIII, B100 and CII) is related with the presence of dislipidaemia in non insulin dependent diabetes mellitus patients. PATIENTS AND METHODS: 53 non insulin dependent diabetes mellitus patients with less than 5 years evolution and treated only with diet, were included. 86 healthy persons were included as the control group. The lipidic parameters analyzed were: cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, apolipoprotein AI, B and lipoprotein (a). The following polymorphic variants were analyzed: RFLP-Sacl of the apolipoprotein AI-CIII-AIV cluster, RFLP-Xbal of the apolipoprotein B100 region and the RFLP-Taql of the apolipoprotein E-CI-CII cluster. RESULTS: There were no genetic nor allelic differences in the distribution of the genes, between controls and diabetic patients. Regarding the apolipoprotein CII gen, the diabetic patients with the T2T2 genotype had higher triglyceride levels (p < 0.01) compared with the remaining genotypes and compared with the control group having the same genotype (p < 0.01) matched for sex, age and body mass index. There was no difference in the metabolic parameters' distribution related to the genotypic distribution of the apolipoproteins AI-CIII and B100 genes. CONCLUSIONS: The apolipoprotein CII can be related with the presence of hypertriglyceridaemia in non insulin dependent diabetes mellitus patients.     

Study of sulfidization of oxidized copper ores during grinding

Institute of Mineral Chemistry, Russian Academy of Sciences, Moscow. Institute of Geology and Geophysics, Siberian Branch, Russian Academy of Sciences, Novosibirsk. Translated from Fiziko-Tekhnicheskie Problemy Razrabotki Poleznykh Iskopaemykh, No. 3, pp. 96–101, May–June, 1993.     

Plasma extracellular superoxide dismutase levels in an Australian population with coronary artery disease

In vitro experiments suggest that free radicals may contribute importantly to atherogenesis. Superoxide dismutase (SOD), particularly extracellular SOD (EC-SOD), which accounts for the majority of SOD biological activity, is a major superoxide scavenger. We explored factors that may affect plasma EC-SOD levels measured by ELISA and assessed the association between plasma EC-SOD and coronary artery disease documented angiographically in 590 white Australian patients 400 ng/mL were heterozygous for the Arg213-->Gly mutation at the EC-SOD gene; there was also a positive correlation with age (r=0.131, P=0.0016). Plasma EC-SOD in current smokers (75. 0+/-9.3 ng/mL) was much lower than in nonsmokers (111.7+/-8.2 ng/mL, P<0.01), and ex-smokers had intermediate levels (84.3+/-7.1 ng/mL). Levels were significantly lower in patients with than in those without a history of acute myocardial infarction (MI) (76.1+/-7.5 versus 110.1+/-6.0 ng/mL, P<0.05), and low plasma EC-SOD was independently associated with an increased likelihood of a history of MI (OR, 2.04; 95% CI, 1.10 to 3.82); higher EC-SOD levels also tended to be associated with delayed onset of MI. In conclusion, our study establishes that in patients assessed by coronary angiography, circulating EC-SOD is lower in men than in women and in smokers of each sex and that low levels are independently associated with a history of MI. These findings are consistent with EC-SOD's being protective and contributing to reduced coronary risk.     

In situ hybridization detection of short viral amplicon sequences within cultured cells and body fluids after the in situ polymerase chain reaction

Using single primer pairs, intracellular gene sequences of cytomegalovirus (CMV-Towne's strain) and alpha-tubulin were amplified (in situ PCR) from cells in human body fluids and in suspensions. Visualization of CMV amplificants was carried out by in situ hybridization (ISH), using both a biotinylated double-stranded DNA probe and a radiolabelled oligonucleotide probe. Visualization of alpha-tubulin amplificants was achieved using both radiolabelled single-stranded cRNA and oligonucleotide probes. Liberated amplificants were also identified by bands of expected size by gel electrophoresis. The specificity of the PCR products was confirmed by Southern blot analysis. Intracellular amplification was identified both in unfixed cells and, optimally, after brief alcohol fixation, whilst maintaining relative isotonicity in all working solutions. For CMV, enhanced signal was observed in cells (cultured fibroblasts or urine sediment) undergoing in situ PCR using either biotinylated or radiolabelled probes compared with controls undergoing ISH alone. For alpha-tubulin, radiolabelled riboprobes and oligoprobes only produced signals within cells (human peripheral lymphocytes, ascitic fluid and bladder washings from routine cytological specimens) after in situ PCR, but not after ISH alone. Morphological evaluation was superior with biotinylated probes, and minimal back-diffusion effect was found compared with radiolabelled probes. Up to 80% of cells survived thermal cycling. In situ PCR detected short sequence (100 bp) foreign DNA and low copy number genomic DNA, and was superior to ISH alone. In contrast to radiolabelled probes, very small CMV amplificants could be detected without a significant 'back-diffusion' effect when using the large biotinylated probe in this model system.     

Characterization of CFRP Laminates’ layups using through-Transmitting ultrasound waves

Ultrasound waves interact strongly with the orientation and sequence of the plies in a layup when propagating in the thickness direction of composite laminates. Also the layup orientation greatly influences its properties in a composite laminate. If the layup orientation of a ply is misaligned, it could result in the part being rejected and discarded. Now, most researchers cut a small coupon from the waste edge and use a microscope to optically verify the ply sequences on important parts. This may add a substantial cost to the production since the test is both labor intensive and performed after the part is cured. A nondestructive technique would be very beneficial, which could be used to test the part after curing and requires less time than the optical test. Therefore we have developed, reduced, and implemented a novel ply-by-ply vector decomposition model for composite laminates fabricated from unidirectional plies. This model decomposes the transmission of a linearly polarized ultrasound wave into orthogonal components through each ply of a laminate. High probability is found, by comparisons between the model and tests, in characterizing cured layups of the laminates by using the proposed method.     

Monolithic integration of thin film μ-heater array with 4-channel WDM transmitter

We integrated a μ-heater array with a multi-wavelength laser array for accurate control of the channel spacing. A μ-heater array was formed on a 4-channel laser array with asymmetric sampled gratings. The lasers showed threshold current of 9-13 mA and slope efficiency of around 0.21 W/A. High side mode suppression ratio over 44 dB was observed as well. With the μ-heaters, all the laser wavelengths were precisely controlled simultaneously. The laser wavelength was red shifted with the μ-heater and the tuning efficiency was 3.3 nm/W. However, thermal crosstalk between neighboring channels was observed and it was measured to be 1.1 nm/W.     

Studies of the coronary circulation in Chagas' heart disease

Pathogenesis of chronic Chagas' heart disease may include various disturbances in the coronary circulation, that could be responsible for the myocardial lesions seen in human hearts and in experimental models of the disease. In this paper we critically reviewed the anatomical and functional abnormalities described in chronic chagasic patients, pertaining to the so-called vascular pathogenetic theory of Chagas' disease. The epicardial coronary arteries are usually free of significant obstructive disease in nonselected groups of chagasic patients examined at autopsy or by coronary angiography. However, chagasic patients who were studied after an episode of acute myocardial infarction, show the same patterns of atherosclerotic coronary artery disease seen in the general nonchagasic population. Studies of chagasic patients with angiographically normal coronary arteries, by several scintigraphy methods, revealed myocardial perfusion abnormalities which may be caused by the microcirculatory derangements described in animals experimentally infected with the T. cruzi. Since hypoperfusion has been detected in regions with normal or mildly impaired wall motion, it is likely that the microvascular disturbances precede and may be causative mechanism for the subsequent myocardial damage. We speculate that hibernating ventricular areas may occur in chagasic patients, on the basis of the evidence gathered from these studies. Recent investigations of chronic patients with Chagas' disease and chest pain showed attenuation of the vasomotor responses to physiological and pharmacological stimuli, in the epicardial coronary arteries.     

A survey of UK manual therapists' practice of and attitudes towards manipulation and its complications

BACKGROUND AND PURPOSE: Little is known about the practice of manipulation by UK physiotherapists. This study was conducted to discover current practice of, and attitudes towards, manipulation among UK manipulative therapists. METHODS: A postal questionnaire was sent to 300 UK manipulative therapists who were members of two professional associations representing differing approaches to manual therapy: the Society of Orthopaedic Medicine (SOM) and the Manipulation Association of Chartered Physiotherapists (MACP). RESULTS: A 50% response rate was achieved and 129 respondents identified themselves as 'users' of manipulation. Anxiety about possible complications was a prominent reason adduced by 'non-users' and 'partial users' for their avoidance of manipulative procedures. The thoracic spine was the region most often manipulated, followed by the lumbar spine. Nineteen per cent of users had encountered complications from manipulation, which were most common in the cervical region and were predominantly non-serious. The majority of SOM members and a minority of MACP members used generalized cervical rotary manipulations--thought by some to be potentially dangerous. Attitudes to manipulation were generally positive, although overall respondents were uncertain as to whether its benefits outweighed its risks. Members of the SOM emerged as more frequent users of manipulation and as less conservative in their attitudes to certain aspects of manipulation. CONCLUSIONS: Allowing for possible under-reporting or other response biases, spinal manipulation emerged as a relatively safe and widely practised technique among this sample.