Green Synthesis of Silymarin–Chitosan Nanoparticles as a New Nano Formulation with Enhanced Anti-Fibrotic Effects against Liver Fibrosis

Background: Silymarin (SIL) has long been utilized to treat a variety of liver illnesses, but due to its poor water solubility and low membrane permeability, it has a low oral bioavailability, limiting its therapeutic potential. Aim: Design and evaluate hepatic-targeted delivery of safe biocompatible formulated SIL-loaded chitosan nanoparticles (SCNPs) to enhance SIL’s anti-fibrotic effectiveness in rats with CCl₄-induced liver fibrosis. Methods: The SCNPs and chitosan nanoparticles (CNPs) were prepared by ionotropic gelation technique and are characterized by physicochemical parameters such as particle size, morphology, zeta potential, and in vitro release studies. The therapeutic efficacy of successfully formulated SCNPs and CNPs were subjected to in vivo evaluation studies. Rats were daily administered SIL, SCNPs, and CNPs orally for 30 days. Results: The in vivo study revealed that the synthesized SCNPs demonstrated a significant antifibrotic therapeutic action against CCl₄-induced hepatic injury in rats when compared to treated groups of SIL and CNPs. SCNP-treated rats had a healthy body weight, with normal values for liver weight and liver index, as well as significant improvements in liver functions, inflammatory indicators, antioxidant pathway activation, and lipid peroxidation reduction. The antifibrotic activities of SCNPs were mediated by suppressing the expression of the main fibrosis mediators TGFβR1, COL3A1, and TGFβR2 by boosting the hepatic expression of protective miRNAs; miR-22, miR-29c, and miR-219a, respectively. The anti-fibrotic effects of SCNPs were supported by histopathology and immunohistochemistry (IHC) study. Conclusions: According to the above results, SCNPs might be the best suitable carrier to target liver cells in the treatment of liver fibrosis.     

Selective Recovery of Cadmium,Cobalt, and Nickel from Spent Ni–Cd Batteries Using Adogen® 464 and Mesoporous Silica Derivatives

Spent Ni–Cd batteries are now considered an important source for many valuable metals. The recovery of cadmium, cobalt, and nickel from spent Ni–Cd Batteries has been performed in this study. The optimum leaching process was achieved using 20% H₂SO₄, solid/liquid (S/L) 1/5 at 80 °C for 6 h. The leaching efficiency of Fe, Cd, and Co was nearly 100%, whereas the leaching efficiency of Ni was 95%. The recovery of the concerned elements was attained using successive different separation techniques. Cd(II) ions were extracted by a solvent, namely, Adogen^® 464, and precipitated as CdS with 0.5% Na₂S solution at pH of 1.25 and room temperature. The extraction process corresponded to pseudo-2nd-order. The prepared PTU-MS silica was applied for adsorption of Co(II) ions from aqueous solution, while the desorption process was performed using 0.3 M H₂SO₄. Cobalt was precipitated at pH 9.0 as Co(OH)₂ using NH₄OH. The kinetic and thermodynamic parameters were also investigated. Nickel was directly precipitated at pH 8.25 using a 10% NaOH solution at ambient temperature. FTIR, SEM, and EDX confirm the structure of the products.     

Structural Analysis of Mitochondrial Dynamics—From Cardiomyocytes to Osteoblasts: A Critical Review

Mitochondria play a crucial role in cell physiology and pathophysiology. In this context, mitochondrial dynamics and, subsequently, mitochondrial ultrastructure have increasingly become hot topics in modern research, with a focus on mitochondrial fission and fusion. Thus, the dynamics of mitochondria in several diseases have been intensively investigated, especially with a view to developing new promising treatment options. However, the majority of recent studies are performed in highly energy-dependent tissues, such as cardiac, hepatic, and neuronal tissues. In contrast, publications on mitochondrial dynamics from the orthopedic or trauma fields are quite rare, even if there are common cellular mechanisms in cardiovascular and bone tissue, especially regarding bone infection. The present report summarizes the spectrum of mitochondrial alterations in the cardiovascular system and compares it to the state of knowledge in the musculoskeletal system. The present paper summarizes recent knowledge regarding mitochondrial dynamics and gives a short, but not exhaustive, overview of its regulation via fission and fusion. Furthermore, the article highlights hypoxia and its accompanying increased mitochondrial fission as a possible link between cardiac ischemia and inflammatory diseases of the bone, such as osteomyelitis. This opens new innovative perspectives not only for the understanding of cellular pathomechanisms in osteomyelitis but also for potential new treatment options.     

A heuristic to solve the synchronized log-truck scheduling problem

We present a synchronized routing and scheduling problem that arises in the forest industry, as a variation of the log-truck scheduling problem. It combines routing and scheduling of trucks with specific constraints related to the Canadian forestry context. This problem includes aspects such as pick-up and delivery, multiple products, inventory stock, multiple supply points and multiple demand points. We developed a decomposition approach to solve the weekly problem in two phases. In the first phase we use a MIP solver to solve a tactical model that determines the destinations of full truckloads from forest areas to woodmills. In the second phase, we make use of two different methods to route and schedule the daily transportation of logs: the first one consists in using a constraint-based local search approach while the second one is a hybrid approach involving a constraint programming based model and a constraint-based local search model. These approaches have been implemented using COMET2.0. The method, was tested on two industrial cases from forest companies in Canada.     

The influence of solid-phase concentration on the performance of electrorheological fluids in dynamic squeeze flow

The yield stress of electrorheological (ER) fluids increases by orders of magnitude when electric field is applied across them. In the absence of the field, ER fluids behave as Newtonian fluids. This paper is concerned with an experimental investigation to determine the rheological performance of ER fluids, consisting of a dielectric liquid carrier with a range of solid-phase concentration. The ER fluid was contained in a squeeze cell, which during motion subjects the fluid to both compressive and tensile loading. The results were analysed in terms of the capacity for the transmission of imposed forces across the fluid and showed a great dependence on the applied D.C voltage and the weight fraction of the dispersed solid-phase. In addition, the implications of the results to vibration control, where the ER fluid is employed in an engine mount, are discussed.     

Multilayer Transitions in Spin-3/2 Blume–Capel Model with RKKY Interaction in a Transverse Field

Using mean-field theory, we have studied the effect of quantum transverse field on the magnetic properties and multilayer transitions in the spin-3/2 Blume–Capel model with RKKY interaction. The system is formed by two magnetic multilayer materials, of different thicknesses, separated by a non magnetic spacer of thickness M. It is found that there exist critical transverse fields above which the multilayer transitions occur. This critical value decreases when increasing the thickness of the nonmagnetic spacer M. Phase diagram is established in different plane of space parameter.     

Effect of phosphoric acid on the performance of low antimony grid of Pb‐acid cell under constant current charging and discharging

Effect of phosphoric acid on the performance of Pb‐1.7%Sb grid of lead‐acid cell is studied in 5 M H₂SO₄ by cyclic galvanostatic polarization and impedance spectroscopy. An increase in capacitance to a maximum is recorded during the initial stages of the electro‐reduction of PbO₂ into Pb(II) compounds and attributed to concurrent compositional and dimensional changes. These changes include removal of O₂ bubbles, insertion of large amounts of H₂SO₄ and H₂O. Efficiency of PbO₂ formation decreases, while its rate of self‐discharge increases with increasing the charging current and in the presence of H₃PO₄. The charge capacity increases with increasing the discharging current due to the decrease in the self‐discharge. The charge capacity is lower in the presence of H₃PO₄. On increasing the cycle number, the corrodibility of the grid increases, because more layers of the surface Pb are involved in the self‐discharge. H₃PO₄ significantly retards the effect of cycle number.     

Optimal power flow using differential evolution algorithm

This paper presents an efficient and reliable evolutionary-based approach to solve the optimal power flow (OPF) problem. The proposed approach employs differential evolution algorithm for optimal settings of OPF problem control variables. The proposed approach is examined and tested on the standard IEEE 30-bus test system with different objectives that reflect fuel cost minimization, voltage profile improvement, and voltage stability enhancement. The proposed approach results are compared with the results reported in the literature. The results show the effectiveness and robustness of the proposed approach.     

On the design of algebraic space-time codes for MIMO block-fading channels

The availability of multiple transmit antennas allows for two-dimensional channel codes that exploit the spatial transmit diversity. These codes were referred to as space-time codes by Tarokh et al. (see ibid., vol.44, p.744-765, Mar. 1998) Most prior works on space-time code design have considered quasi-static fading channels. We extend our earlier work on algebraic space-time coding to block-fading channels. First, we present baseband design criteria for space-time codes in multi-input multi-output (MIMO) block-fading channels that encompass as special cases the quasi-static and fast fading design rules. The diversity advantage baseband criterion is then translated into binary rank criteria for phase shift keying (PSK) modulated codes. Based on these binary criteria, we construct algebraic space-time codes that exploit the spatial and temporal diversity available in MIMO block-fading channels. We also introduce the notion of universal space-time codes as a generalization of the smart-greedy design rule. As a part of this work, we establish another result that is important in its own right: we generalize the full diversity space-time code constructions for quasi-static channels to allow for higher rate codes at the expense of minimal reductions in the diversity advantage. Finally, we present simulation results that demonstrate the excellent performance of the proposed codes.     

A unified framework for tree search decoding: rediscovering the sequential decoder

We consider receiver design for coded transmission over linear Gaussian channels. We restrict ourselves to the class of lattice codes and formulate the joint detection and decoding problem as a closest lattice point search (CLPS). Here, a tree search framework for solving the CLPS is adopted. In our framework, the CLPS algorithm is decomposed into the preprocessing and tree search stages. The role of the preprocessing stage is to expose the tree structure in a form matched to the search stage. We argue that the forward and feedback (matrix) filters of the minimum mean-square error decision feedback equalizer (MMSE-DFE) are instrumental for solving the joint detection and decoding problem in a single search stage. It is further shown that MMSE-DFE filtering allows for solving underdetermined linear systems and using lattice reduction methods to diminish complexity, at the expense of a marginal performance loss. For the search stage, we present a generic method, based on the branch and bound (BB) algorithm, and show that it encompasses all existing sphere decoders as special cases. The proposed generic algorithm further allows for an interesting classification of tree search decoders, sheds more light on the structural properties of all known sphere decoders, and inspires the design of more efficient decoders. In particular, an efficient decoding algorithm that resembles the well-known Fano sequential decoder is identified. The excellent performance-complexity tradeoff achieved by the proposed MMSE-DFE Fano decoder is established via simulation results and analytical arguments in several multiple-input multiple-output (MIMO) and intersymbol interference (ISI) scenarios.