Assessment of sperm count in rural population of central India

26 clinician trainees' recollections of experiences in a diagnostic preschool program were analyzed in terms of strength and weaknesses of the program.     

Transient Turbulent Flow in a Liquid-Metal Model of Continuous Casting,Including Comparison of Six Different Methods

Computational modeling is an important tool to understand and stabilize transient turbulent fluid flow in the continuous casting of steel to minimize defects. The current work combines the predictions of two steady Reynolds-averaged Navier–Stokes (RANS) models, a “filtered” unsteady RANS model, and two large eddy simulation (LES) models with ultrasonic Doppler velocimetry (UDV) measurements in a small-scale liquid GaInSn model of the continuous casting mold region fed by a bifurcated well-bottom nozzle with horizontal ports. Both mean and transient features of the turbulent flow are investigated. LES outperformed all models while matching the measurements, except in locations where measurement problems are suspected. The LES model also captured high-frequency fluctuations, which the measurements could not detect. Steady RANS models were the least accurate methods. Turbulent velocity variation frequencies and energies decreased with distance from the nozzle port regions. Proper orthogonal decomposition analysis, instantaneous velocity patterns, and Reynolds stresses reveal that velocity fluctuations and flow structures associated with the alternating-direction swirl in the nozzle bottom lead to a wobbling jet exiting the ports into the mold. These turbulent flow structures are responsible for patterns observed in both the time average flow and the statistics of their fluctuations.     

Surfactant assisted synthesis and spectroscopic characterization of selenium nanoparticles in ambient conditions

In this work, an attempt has been made to synthesize well-distributed stable selenium (Se) particles of nanosize dimensions via an aqueous micellar solution by the assistance of surfactants of two different polarities (anionic, sodium bis(2-ethylhexyl)sulfosuccinate (AOT) and cationic, hexadecyltrimethylammonium bromide (CTAB)). The morphology of the particles was examined with transmission electron microscopy (TEM). X-ray analysis reveals that the particles have a monoclinic structure. The band gap of the particles was determined from UV-visible optical spectroscopic results. The size variation was estimated by employing a quantum confinement effect equation. The evolution of the selenium nanoparticles in AOT and CTAB micellar media was corroborated with the time-dependent absorption spectra. The influence of hydrazine hydrate concentrations on the formation kinetics of Se nanoparticles was also investigated. The capping ability of the surfactants has been quantitatively evaluated from Fourier transform infrared (FTIR) studies.     

Effect of Electromagnetic Ruler Braking (EMBr) on Transient Turbulent Flow in Continuous Slab Casting using Large Eddy Simulations

Static electromagnetic braking (EMBr) fields affect greatly the turbulent flow pattern in steel continuous casting, which leads to potential benefits such as decreasing flow instability, surface defects, and inclusion entrapment if applied correctly. To gain a fundamental understanding of how EMBr affects transient turbulent flow, the current work applies large eddy simulations (LES) to investigate the effect of three EMBr ruler brake configurations on transient turbulent flow through the bifurcated nozzle and mold of a liquid-metal GaInSn model of a typical steel slab-casting process, but with deep nozzle submergence and insulated walls with no solidifying shell. The LES calculations are performed using an in-house graphic-processing-unit-based computational-fluid-dynamics code (LES-CU-FLOW) on a mesh of ~7?million brick cells. The LES model is validated first via ultrasonic velocimetry measurements in this system. It is then applied to quantify the mean and instantaneous flow structures, Reynolds stresses, turbulent kinetic energy and its budgets, and proper orthogonal modes of four cases. Positioning the strongest part of the ruler magnetic field over the nozzle bottom suppresses turbulence in this region, thus reducing nozzle well swirl and its alternation. This process leads to strong and focused jets entering the mold cavity making large-scale and low-frequency (<0.02?Hz) flow variations in the mold with detrimental surface velocity variations. Lowering the ruler below nozzle deflects the jets upward, leading to faster surface velocities than the other cases. The double-ruler and no-EMBr cases have the most stable flow. The magnetic field generates large-scale vortical structures tending toward two-dimensional (2-D) turbulence. To avoid detrimental large-scale, low-frequency flow variations, it is recommended to avoid strong magnetic fields across the nozzle well and port regions.     

Temperature-dependent formation of a conjugate between tris(hydroxymethyl)aminomethane buffer and the malondialdehyde-DNA adduct pyrimidopurinone

OBJECTIVE: To examine the effects of cardiopulmonary bypass (CPB) on total and unbound plasma concentrations of propofol and midazolam when administered by continuous infusion during cardiac surgery. DESIGN: Prospective clinical study. SETTING: University hospital. PARTICIPANTS: Twenty-four adult patients undergoing cardiac surgery. INTERVENTIONS: Patients received either propofol or midazolam to supplement fentanyl anesthesia. Twelve patients received a propofol bolus (1 mg/kg) followed by an infusion of 3 mg/kg/hr. A second group received midazolam, 0.2 mg/kg bolus, followed by an infusion of 0.07 mg/kg/hr. MEASUREMENTS AND MAIN RESULTS: Blood sample were collected from the radial artery cannula at 0, 2, 4, 8, 8, 10, 15, 20 minutes and then every 10 minutes before CPB, at 1, 2, 3, 4, 6, 10, 15, 20 minutes and then each 10 minutes during CPB. On weaning from CPB samples were collected at 0, 5, 10 and 20 minutes. Plasma binding, total and unbound propofol and midazolam concentrations were determined by ultrafiltration and high-pressure liquid chromatography (HPLC). CPB resulted in a fall in total propofol and midazolam plasma concentrations, but the unbound concentrations remained stable. The propofol unbound fraction increased from 0.22 +/- 0.06% to 0.41 +/- 0.17%. The midazolam unbound fraction increased from 5.6 +/- 1.0% to 11.2 +/- 2.1%. CONCLUSIONS: Unbound concentrations of propofol and midazolam are not affected by cardiopulmonary bypass. Total intravenous anesthesia algorithms do not need to be changed to achieve stable unbound plasma concentrations when initiating CPB.     

Segment III cholangiojejunostomy for carcinoma of the gallbladder

Jaundice in patients of advanced carcinoma of the gallbladder requires palliation for the distressing symptoms of pruritus and cholangitis. Intrahepatic segment III duct cholangiojejunostomy is a means for alleviating the obstruction with malignant porta block. The authors reviewed their experience with this procedure in 48 patients of carcinoma of the gallbladder. All patients had jaundice; pruritus was present in 44 (92%) and cholangitis in 14 (29%). The level of obstruction was determined preoperatively by percutaneous transhepatic cholangiography. In 32 patients the block was below the level of the bifurcation of the right and left ducts, and 16 patients had a block involving the confluence, isolating the two lobes of the liver. Following segment III cholangiojejunostomy, pruritus was relieved in all and cholangitis in 86% of patients. At the end of 6 weeks a significant fall in serum bilirubin and alkaline phosphatase levels was seen with both types of hilar obstruction. Varying degrees of pain relief was also noted in 75% of patients. Segment III biliary bypass is an effective, one-time, reliable means of palliation for carcinoma of the gallbladder with hilar obstruction. Its efficacy appears to depend on the duration and depth of the jaundice and on the anatomy of the biliary ductal system in the left hemiliver rather than on the type of hilar obstruction.     

Dissolution System for Nifedipine Sustained Release Formulations

An in-vitro system for evaluating Nifedipine sustained release formulations has been developed. Two systems were evaluated to simulate sink conditions and correlate the system with flow through dissolution system in mechanism. For the purpose of evaluation two commercial brands were studied. The acidic biphasic system was found to be good for in-vitro dissolution rate evaluation of sustained release nifedipine tablets. It can be successfully utilized for routine quality control work.     

Stacked rectangular dielectric resonator antenna with different volumes for wideband circular polarization coupled with step‐shaped conformal strip

This paper presents a wideband circularly polarized broadside radiation characteristics by using stacked rectangular dielectric resonator antenna (DRA) with different volumes. In this designed antenna, the wide input impedance‐ and axial ratio (AR)‐bandwidths come from three factors: stacked rectangular DR with different volumes, stepped‐shaped conformal strip associated with microstrip line as a feed and different type of partial ground plane. Here, the orthogonal TE^x_δ11 and TE^y_1δ1 modes have been responsible for the generation of CP radiation in stacked rectangular DRA. Measured results show that the proposed stacked rectangular DRA with different volumes achieves input impedance bandwidth of 54.84% while AR bandwidth has been found to be 11.53%. The proposed antenna provides broadside right‐handed CP radiation pattern with gain ranges from 2.27–5.80 dBic and offers an average radiation efficiency of 89.48%, across the entire working bandwidth, respectively. Therefore, this antenna is very much useful for the ISM 2400 band applications.