Parallel imports and unparallel laws: an examination of the exhaustion doctrine through the lens of pharmaceutical products

Parallel imports, the natural consequence of exhaustion doctrine, represent a complex interaction between the issue of free flow of international trade and the protection of intellectual property rights. There is considerable divergence among scholars, both economic and legal, about the need for harmonisation of principles of exhaustion, and consequently parallel import laws. In this article, we examine the need for harmonisation of parallel import laws through the lens of pharmaceutical products. We highlight the necessity for the affirmative norm of exhaustion doctrine in the Trade Related Intellectual Property Rights (TRIPS) Agreement and suggest amendment to TRIPS Agreement Article 6 mandating international exhaustion doctrine as international legal standard with limited exceptions as an intermediate approach to strike a balance between the interests of the IP owners and consumers, and concurrently addressing the concerns of developed and developing countries.     

Widespread presence of naturally occurring perchlorate in high plains of Texas and New Mexico

Perchlorate (CLO4-) occurrence in groundwater has previously been linked to industrial releases and the historic use of Chilean nitrate fertilizers. However, recently a number of occurrences have been identified for which there is no obvious anthropogenic source. Groundwater from an area of 155,000 km2 in 56 counties in northwest Texas and eastern New Mexico is impacted bythe presence of ClO4-. Concentrations were generally low (<4 ppb), although some areas are impacted by concentrations up to 200 ppb. ClO4- distribution is not related to well type (public water system, domestic, agricultural, or water-table monitoring) or aquifer (Ogallala, Edward Trinity High Plains, Edwards Trinity Plateau, Seymour, or Cenozoic). Results from vertically nested wells strongly indicate a surface source. The source of ClO4- appears to most likely be atmospheric deposition. Evidence supporting this hypothesis primarily relates to the presence of ClO4- in tritium-free older water, the lack of relation between land use and concentration distribution, the inability of potential anthropogenic sources to account for the estimated mass of ClO4-, and the positive relationship between conserved anions (e.g., IO3-, Cl-, SO4(-2)) and ClO4-. The ClO4- distribution appears to be mainly related to evaporative concentration and unsaturated transport. This process has led to higher ClO4- and other ion concentrations in groundwater where the water table is relatively shallow, and in areas with lower saturated thickness. Irrigation may have accelerated this process in some areas by increasing the transport of accumulated salts and by increasing the number of evaporative cycles. Results from this study highlight the potential for ClO4- to impact groundwater in arid and semi-arid areas through long-term atmospheric deposition.     

Partial shape classification using contour matching in distancetransformation

An algorithm is presented to recognize and locate partially distorted 2D shapes without regard to their orientation, location, and size. The algorithm first calculates the curvature function from the digitized image of an object. The points of local maxima and minima extracted from the smooth curvature are used as control points to segment the boundary and to guide the boundary-matching procedure. The boundary-matching procedure considers two shapes at a time, one shape from the template databank, and the other from the object being classified. The procedure tries to match the control points in the unknown shape to those of a shape from the template databank, and estimates the translation, rotation, and scaling factors to be used to normalize the boundary of the unknown shape. The chamfer 3/4 distance transformation and a partial distance measurement scheme constitute the final step in measuring the similarity between the two shapes. The unknown shape is assigned to the class corresponding to the minimum distance. The algorithm has been successfully tested on partial shapes using two sets of data, one with sharp corners and the other with curve segments. This algorithm not only is computationally simple, but also works reasonably well in the presence of a moderate amount of noise     

Overview of the Plasma Science and Innovation Center (PSI – Center)

The principal goal of the Plasma Science and Innovation Center (PSI – Center) is to achieve significantly improved computational predictive capability for smaller-scale devices. This is being accomplished through the refinement of existing computational tools through adding sufficient physics modeling, boundary conditions, and geometric capabilities while benchmarking results against experimental data. The work emphasizes the modeling needs of emerging concept (EC) experiments, but improved simulation capabilities for all innovative confinement concepts (ICC) are expected. A special emphasis is placed on physics effects that may extend beyond the standard analysis applied to the mainline programs.     

Acute miliary blastomycosis in an AIDS patient

The incidence of blastomycosis in immunocompromised patients with HIV infection is very low when compared to other mycoses. Of the 19 cases of blastomycosis described in HIV-infected patients, only four had a miliary pattern on chest x-ray. A case of acute miliary blastomycosis in an HIV infected patient from Louisville is described.     

Goal directed life cycle costing as a method to evaluate the economic feasibility of office buildings with conventional and TI‐façades

Transparent insulation systems (TI‐systems) of less than 20cm thick have been developed as an alternative to opaque wall insulation and windows, which provide a financial return to building occupants when applied to building façades. Lack of detailed cost analysis of TI‐systems is a major constraint to the application of TI‐wall and TI‐glazing in buildings. A goal directed life cycle costing (LCC) technique and sensitivity analysis used to evaluate the economic feasibility of TI‐applications in office buildings form the basis of this research. It was undertaken as part of research to determine optimum energy and cost performance of TI‐systems for external cladding of high‐rise and low‐rise office buildings in temperate and tropical climates. The LCC of the buildings with conventional façades were compared with those with TI‐façades. The results show that LCC can be used to evaluate the economic feasibility of low carbon technologies such as TI‐systems effectively. A detailed account is provided of how different sources of cost data can be captured, collected and integrated to perform selective goal directed LCC analysis in the absence of detailed historical LCC data. The use of the goal directed LCC method and cost influence diagram presented in this research can be adopted as a standard method for assessing the economic feasibility of applying low carbon technologies to buildings.     

In Pursuit of Zero: Polymer Brushes that Resist the Adsorption of Proteins

Protein resistant or “non‐fouling” surfaces are of great interest for a variety of biomedical and biotechnology applications. This article briefly reviews the development of protein resistant surfaces, followed by recent research on a new methodology to fabricate non‐fouling surfaces by surface‐initiated polymerization. We show that polymer brushes synthesized by surface‐initiated polymerization that present short oligo(ethylene glycol) side chains are exceptionally resistant to protein adsorption and cell adhesion. The importance of the protein and cell resistance conferred by these polymer brushes is illustrated by their use as substrates for the fabrication of antibody microarrays that exhibit femtomolar limits of detection in complex fluids such as serum and blood with relaxed requirements for intermediate wash steps. This example highlights the important point that the reduction in background noise afforded by protein‐resistant surfaces can greatly simplify the development of ultrasensitive heterogeneous, surface‐based clinical and proteomic assays with increased sensitivity and utility.