Neurochemical Alterations in Social Anxiety Disorder (SAD): A Systematic Review of Proton Magnetic Resonance Spectroscopic Studies

(1) Objective: Considering that current knowledge of mechanisms involved in the molecular pathogenesis of Social Anxiety Disorder (SAD) is limited, we conducted a systematic review to evaluate cumulative data obtained by Proton Magnetic Resonance Spectroscopic (¹H MRS) studies. (2) Methods: A computer-based literature search of Medline, EMBASE, PsycInfo, and ProQuest was performed. Only cross-sectional studies using ¹H MRS techniques in participants with SAD and healthy controls (HCs) were selected. (3) Results: The search generated eight studies. The results indicated regional abnormalities in the ‘fear neurocircuitry’ in patients with SAD. The implicated regions included the anterior cingulate cortex (ACC), dorsomedial prefrontal cortex (dmPFC), dorsolateral prefrontal cortex (dlPFC), insula, occipital cortex (OC), as well as the subcortical regions, including the thalamus, caudate, and the putamen. (4) Conclusions: The evidence derived from eight studies suggests that possible pathophysiological mechanisms of SAD include impairments in the integrity and function of neurons and glial cells, including disturbances in energy metabolism, maintenance of phospholipid membranes, dysregulations of second messenger systems, and excitatory/inhibitory neurocircuitry. Conducting more cross-sectional studies with larger sample sizes is warranted given the limited evidence in this area of research.     

Parameterized Two-Player Nash Equilibrium

We study the problem of computing Nash equilibria in a two-player normal form (bimatrix) game from the perspective of parameterized complexity. Recent results proved hardness for a number of variants, when parameterized by the support size. We complement those results, by identifying three cases in which the problem becomes fixed-parameter tractable. Our results are based on a graph-theoretic representation of a bimatrix game, and on applying graph-theoretic tools on this representation.     

Structure,homogeneity ranges,magnetic, and electrical properties of the ordered Laves phases RENi4Mg with MgCu4Sn type structure

New ordered Laves phases RENi₄Mg (RE = Sc, Sm, Tb–Lu) were synthesized from the elements in sealed tantalum ampoules in an induction furnace. Six of the structures were refined on the basis of X-ray single crystal data. The diffraction experiments gave hint for small homogeneity ranges RE_1+xNi₄Mg_1?x. Magnetic susceptibility measurements show Curie–Weiss behavior for RE = Gd, Dy, Ho, Tm, Yb and the resulting effective magnetic moments suggest both stable trivalent states for all RE and a non-magnetic state for Ni. Gd_1+xNi₄Mg_1?x (x ≈ 0.12) orders antiferromagnetically at a Néel temperature of T_N = 4.6(5) K. Resistivity measurements reflect the metallic nature of these compounds.     

Deficits in emotion-regulation skills predict alcohol use during and after cognitive–behavioral therapy for alcohol dependence.

Objective: As emotion regulation is widely considered to be a primary motive in the misuse of alcohol, our aim in the study was to investigate whether deficits in adaptive emotion-regulation skills maintain alcohol dependence (AD). Method: A prospective study investigated whether emotion-regulation skills were associated with AD and whether these skills predicted alcohol use during and after treatment for AD. Participants were 116 individuals treated for AD with cognitive–behavioral therapy. Emotion regulation and severity of AD symptoms were assessed by self-report. Alcohol use during treatment was assessed by Breathalyzer and urine analysis for ethyl glucuronide; alcohol use during the 3-month follow-up interval was assessed by self-report. Results: Pretreatment emotion-regulation skills predicted alcohol use during treatment, and posttreatment emotion-regulation skills predicted alcohol use at follow-up, even when controlling for other predictors potentially related to emotion regulation. Among a broad range of specific emotion-regulation skills, the ability to tolerate negative emotions was the only skill that negatively predicted subsequent alcohol consumption when controlling for the other skills. Individuals in the AD sample reported significantly larger deficits in emotion-regulation skills than did those in a nonclinical control sample but significantly less than did those in a sample of individuals exclusively meeting criteria for major depressive disorder. Conclusions: Enhancement of general emotion-regulation skills, especially the ability to tolerate negative emotions, appears to be an important target in the treatment of AD. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Self‐Assembly of Mechanoplasmonic Bacterial Cellulose–Metal Nanoparticle Composites

Nanocomposites of metal nanoparticles (NPs) and bacterial nanocellulose (BC) enable fabrication of soft and biocompatible materials for optical, catalytic, electronic, and biomedical applications. Current BC–NP nanocomposites are typically prepared by in situ synthesis of the NPs or electrostatic adsorption of surface functionalized NPs, which limits possibilities to control and tune NP size, shape, concentration, and surface chemistry and influences the properties and performance of the materials. Here a self‐assembly strategy is described for fabrication of complex and well‐defined BC–NP composites using colloidal gold and silver NPs of different sizes, shapes, and concentrations. The self‐assembly process results in nanocomposites with distinct biophysical and optical properties. In addition to antibacterial materials and materials with excellent senor performance, materials with unique mechanoplasmonic properties are developed. The homogenous incorporation of plasmonic gold NPs in the BC enables extensive modulation of the optical properties by mechanical stimuli. Compression gives rise to near‐field coupling between adsorbed NPs, resulting in tunable spectral variations and enhanced broadband absorption that amplify both nonlinear optical and thermoplasmonic effects and enables novel biosensing strategies.     

Evaluation of optimization methods for nonrigid medical image registration using mutual information and B-splines.

A popular technique for nonrigid registration of medical images is based on the maximization of their mutual information, in combination with a deformation field parameterized by cubic B-splines. The coordinate mapping that relates the two images is found using an iterative optimization procedure. This work compares the performance of eight optimization methods: gradient descent (with two different step size selection algorithms), quasi-Newton, nonlinear conjugate gradient, Kiefer-Wolfowitz, simultaneous perturbation, Robbins-Monro, and evolution strategy. Special attention is paid to computation time reduction by using fewer voxels to calculate the cost function and its derivatives. The optimization methods are tested on manually deformed CT images of the heart, on follow-up CT chest scans, and on MR scans of the prostate acquired using a BFFE, T1, and T2 protocol. Registration accuracy is assessed by computing the overlap of segmented edges. Precision and convergence properties are studied by comparing deformation fields. The results show that the Robbins-Monro method is the best choice in most applications. With this approach, the computation time per iteration can be lowered approximately 500 times without affecting the rate of convergence by using a small subset of the image, randomly selected in every iteration, to compute the derivative of the mutual information. From the other methods the quasi-Newton and the nonlinear conjugate gradient method achieve a slightly higher precision, at the price of larger computation times.     

Optimal DLC protocol configuration for realistic broadband fixed wireless access networks based on ATM

DLC protocols, scheduling, and multiplexing issues for broadband fixed wireless access networks based on ATM are discussed. The established DSA++ mac protocol has been developed at ComNets and has been widely applied within the German project ATMmobil. It has been a fundamental contribution to the etsi bran standardisation of HIPERLAN /2. The DSA++ is here modified to perform optimal within the fixed wireless access network environment. Therefore, realistic traffic as well as radio channel models for the respective scenarios are introduced. Simulation results are presented, showing the feasibility of the respective protocol stack for offering broadband multimedia services with reasonable quality of service. In addition to this advanced protocol approach, two systems are discussed which are currently under standardisation process. The IEEE 802.16 as well as the European hiperaccess systems are both proposed for fixed wireless access networks. Expected scenarios and applications are presented and basic requirements the standards have to fulfil are derived. As another aspect of access networks, their impact on the global information society is discussed.     

Area, Delay, and Power Characteristics of Standard-Cell Implementations of the AES S-Box

Cryptographic substitution boxes (S-boxes) are an integral part of modern block ciphers like the Advanced Encryption Standard (AES). There exists a rich literature devoted to the efficient implementation of cryptographic S-boxes, wherein hardware designs for FPGAs and standard cells received particular attention. In this paper we present a comprehensive study of different standard-cell implementations of the AES S-box with respect to timing (i.e. critical path), silicon area, power consumption, and combinations of these cost metrics. We examine implementations which exploit the mathematical properties of the AES S-box, constructions based on hardware look-up tables, and dedicated low-power solutions. Our results show that the timing, area, and power properties of the different S-box realizations can vary by up to almost an order of magnitude. In terms of area and area-delay product, the best choice are implementations which calculate the S-box output. On the other hand, the hardware look-up solutions are characterized by the shortest critical path. The dedicated low-power implementations do not only reduce power consumption by a large degree, but they also show good timing properties and offer the best power-delay and power-area product, respectively.