Near-wall porosity characteristics of fixed beds packed with wood chips

Packed beds of fuel wood chips are commonly found in thermal conversion processes such as combustion or gasification. Wood chips in particular are mostly used as fuel for small-scale domestic heating boilers but also for commercial-scale combustion units. The characterization of spatial voidage distribution inside the wood chip beds is of great importance for flow and reactor modelling. This study focuses on the radial porosity variations of cylindrical beds of three different types of commercially available wood chips including chips classified as G30 size class. The conventional technique of consolidating packed beds with a resin was chosen as the experimental procedure. The radial voidage distribution in different cylindrical beds is determined by image analysis of sections of the solidified packings. Additionally, a packing of monosized spheres was investigated in order to assess the selected procedure in comparison with widely available literature data for spheres. The results are discussed and summarized in a mathematical expression correlating the radial voidage distribution depending on average wood chip size, packing core porosity and dimensionless distance from the tube wall.     

Production of niobium powder by magnesiothermic reduction of niobium oxides in a cyclone reactor

In the last years, a variety of processes respectively process steps have been investigated for the production of niobium powder. This is due to the fact that niobium capacitors could be a viable alternative to tantalum capacitors from a performance, availability, and price point of view. The reduction of niobium pentoxide by magnesium results in fine powders with high specific surface area but has the disadvantages of a very exothermic nature and the formation of magnesium niobate. It is shown in this work that the application of a continuously operating cyclone reactor and the use of niobium(IV) oxide as raw material solve these problems. A good control of the highly exothermic reaction within the cyclone reactor was achieved in the cyclone reactor by the ratio between gas flow rate and powder flow rate as well as by a proper preheating of the gas.     

Integrationsdefizite des IT-Controllings

Zusammenfassung  Der Beitrag basiert auf der Annahme, dass das IT-Controlling in zweifacher Hinsicht unter einem Integrationsdefizit leidet. Dies gilt zum einen für die unbefriedigende Synchronisation der Forschung mit Entwicklungen in der Praxis, zum anderen für die unzureichende Verzahnung mit den Methoden der Wirtschaftsinformatik. Ausgehend von dieser Annahme untersucht der Beitrag die historische Entwicklung des IT-Controllings, um daraus Thesen zum Integrationsstand abzuleiten. Die Untersuchung kommt zu dem Ergebnis, dass Hinweise auf – nach wie vor – ungenutzte Integrationspotenziale vorliegen und identifiziert Potenziale einer weiter gehenden Integration. Aus der Analyse identifizierter Integrationspotenziale werden Anforderungen an eine methodenbezogene Integration abgeleitet und die Realisierung von Integrationspotenzialen an zwei Beispielen illustriert. This article is also available in English via and : Strecker S, Kargl H (2009) Integration Deficits of IT Controlling – Historical Background, Analysis of Integration Potentials and Method Integration. Bus Inf Syst Eng. doi: 10.1007/s12599-009-0053-4.     

An approach to analyzing and planning post-merger IS integration: Insights from two field studies

Information systems (IS) integration is among the most challenging tasks in corporate mergers and acquisitions (M&As). In this paper we propose and illustrate the use of an approach to analyzing and planning post-merger IS integration that extends general theory for IS planning, considering the specific characteristics of the M&A context. We highlight that planning effectiveness is possible to achieve in fundamentally different ways, dependent on the characteristics of the merger or acquisition at hand.

From use cases to test cases via meta model-based reasoning

In Use cases considered harmful, Simons has analyzed the logical weaknesses of the UML use case notation and has recommended to “fix the faulty notion of dependency” (Simons: Use cases considered harmful. 29th Conference on Techn. of OO Lang. and Syst., pp 194–203, 1999). The project sketched in this position paper is inspired by Simons’ critique. The main contribution of this paper is a detailed meta model of possible relations between use cases. Later in the project this meta model is then to be formalized in a natural deduction calculus which shall be implemented in the Prolog. As a result of such formalization a use case specification can be queried for inconsistencies as well as for test cases which must be observable after a software system is implemented based on such a use case specification. Software tool support for this method is also under development.     

Revisiting the Roles of Filaggrin in Atopic Dermatitis

The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology research community and shed new light on a skin protein that was first identified in 1981. However, although outstanding work has uncovered several key functions of filaggrin in epidermal homeostasis, a comprehensive understanding of how filaggrin deficiency contributes to AD is still incomplete, including details of the upstream factors that lead to the reduced amounts of filaggrin, regardless of genotype. In this review, we re-evaluate data focusing on the roles of filaggrin in the epidermis, as well as in AD. Filaggrin is important for alignment of keratin intermediate filaments, control of keratinocyte shape, and maintenance of epidermal texture via production of water-retaining molecules. Moreover, filaggrin deficiency leads to cellular abnormalities in keratinocytes and induces subtle epidermal barrier impairment that is sufficient enough to facilitate the ingress of certain exogenous molecules into the epidermis. However, although FLG null mutations regulate skin moisture in non-lesional AD skin, filaggrin deficiency per se does not lead to the neutralization of skin surface pH or to excessive transepidermal water loss in atopic skin. Separating facts from chaff regarding the functions of filaggrin in the epidermis is necessary for the design efficacious therapies to treat dry and atopic skin.     

Sphingolipid Catabolism and Glycerophospholipid Levels Are Altered in Erythrocytes and Plasma from Multiple Sclerosis Patients

Multiple sclerosis (MS) is an autoimmune, inflammatory, degenerative disease of the central nervous system. Changes in lipid metabolism have been suggested to play important roles in MS pathophysiology and progression. In this work we analyzed the lipid composition and sphingolipid-catabolizing enzymes in erythrocytes and plasma from MS patients and healthy controls. We observed reduction of sphingomyelin (SM) and elevation of its products—ceramide (CER) and shingosine (SPH). These changes were supported by the detected up-regulation of the activity of acid sphingomyelinase (ASM) in MS plasma and alkaline ceramidase (ALCER) in erythrocytes from MS patients. In addition, Western blot analysis showed elevated expression of ASM, but not of ALCER. We also compared the ratios between saturated (SAT), unsaturated (UNSAT) and polyunsaturated fatty acids and suggest, based on the significant differences observed for this ratio, that the UNSAT/SAT values could serve as a marker distinguishing erythrocytes and plasma of MS from controls. In conclusion, the application of lipid analysis in the medical practice would contribute to definition of more precise diagnosis, analysis of disease progression, and evaluation of therapeutic strategies. Based on the molecular changes of blood lipids in neurodegenerative pathologies, including MS, clinical lipidomic analytical approaches could become a promising contemporary tool for personalized medicine.     

Preclinical Assessment of the Combination of PSMA-Targeting Radionuclide Therapy with PARP Inhibitors for Prostate Cancer Treatment

Prostate specific membrane antigen targeted radionuclide therapy (PSMA-TRT) is a promising novel treatment for prostate cancer (PCa) patients. However, PSMA-TRT cannot be used for curative intent yet, thus additional research on how to improve the therapeutic efficacy is warranted. A potential way of achieving this, is combining TRT with poly ADP-ribosylation inhibitors (PARPi), which has shown promising results for TRT of neuroendocrine tumor cells. Currently, several clinical trials have been initiated for this combination for PCa, however so far, no evidence of synergism is available for PCa. Therefore, we evaluated the combination of PSMA-TRT with three classes of PARPi in preclinical PCa models. In vitro viability and survival assays were performed using PSMA-expressing PCa cell lines PC3-PIP and LNCaP to assess the effect of increasing concentrations of PARPi veliparib, olaparib or talazoparib in combination with PSMA-TRT compared to single PARPi treatment. Next, DNA damage analyses were performed by quantifying the number of DNA breaks by immunofluorescent stainings. Lastly, the potential of the combination treatments was studied in vivo in mice bearing PC3-PIP xenografts. Our results show that combining PSMA-TRT with PARPi did not synergistically affect the in vitro clonogenic survival or cell viability. DNA-damage analysis revealed only a significant increase in DNA breaks when combining PSMA-TRT with veliparib and not in the other combination treatments. Moreover, PSMA-TRT with PARPi treatment did not improve tumor control compared to PSMA-TRT monotherapy. Overall, the data presented do not support the assumption that combining PSMA-TRT with PARPi leads to a synergistic antitumor effect in PCa. These results underline that extensive preclinical research using various PCa models is imperative to validate the applicability of the combination strategy for PCa, as it is for other cancer types.