Fast method to compute the scalar product of gradient and given vector

The paper deals with a special problem in Automatic Differentiation. Letf be a rational function ofn variables, let #(f) denote the number of operations to evaluatef(x), letg denote the gradient off. Many algorithms for minimizingf(x) require the scalar productg(u) ^tv. In the standard method for computingg(u) ^tv the amount of work grows withn·#(f). In this note a new method for computingg(u) ^tv is presented. The new method is considerably faster, its amount of work only grows with #(f).     

The possibility of evolving a theory for predicting the service life of reinforced concrete structures

The development in recent years with increasing air pollution, increasing need of energy saving and last not least the growing number of damage in old structures leads to a raising demand to calculate the durability of structures, too. The paper has been prepared by request of the RILEM Technical Committee 45-LTO to show that, in principle, it is possible to evolve a theory for predicting the service life of r.c. structures and to sketch a way how that could be achieved. A lot of necessary basic data can be found scattered in the literature. To collect these data will be the first step to take.     

How to avoid logarithms in comparisons with uniform random variables

In many algorithms for sampling from non-uniform distributions the logarithm of a uniform deviate must be compared with some test quantity. It is shown that all these comparisons can be done efficiently without calling a logarithm subprogram: two procedures for this task are presented and compared.     

On plastic potentials for anisotropic metals and their derivation from the texture function

Summary Plastic yielding of anisotropic metals can be either described by a macroscopic constitutive relation or assessed by means of a model which correlates single and polycrystal behaviors. The mathematical identification of the plastic work rate derived from the two approaches, for all strain rate tensors, leads to a fit of the polycrystal yield surface by an analytical function. When a quadratic from is assumed, the macroscopic anisotropy parameters become explicit functions of the texture coefficients. This identification method is applied to calculate yield surfaces andR-values of rolled and annealed steel sheets: theR-values and in general the flow rule, are more significantly modified by the fitting than the yield surface. Thus, it is worth extending the method to more general constitutive relations which may be given by the form of their work function: alternative forms of the work function for plastic materials are explored, especially in the bearing of convexity and homogeneity where quadratic forms have a distinct advantage. Finally, it is shown that the identification of the work function allows to express the phenomenological coefficients as analytical functions of the texture parameters for many forms of the work function; in the other cases, these coefficients may be obtained by linear or non-linear regression.     

Enhancement Effects in the Percutaneous Absorption of Alprazolam Through Human Skin in vitro

The enhancement effects of some chemicals on the percutaneous absorption of alprazolam through human skin was investigated in vitro. Linoleic acid, oleic acid, Comperlan F® (linoleic acid diethanolamide), Comperlan KD® (coconut fatty acid diethanolamide) and Ethomeen C12® (bis-(2-hydroxyethyl)cocamine) were evaluated for their enhancing effect either as neat solvents or combined with propylene glycol. The effects of skin pretreatment with the enhancers on the percutaneous absorption of alprazolam from a drug suspension in an aqueous gel were also investigated: skin pretreatment with some enhancers has shown potentially interesting aspects. The determination of alprazolam partitioning into untreated and pretreated horny layer supported the idea that, with oleic and linoleic acid, a contribution to the modification of the diffusional resistance of the skin was given by an increase of the drug solubility in the stratum coraeum.     

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