In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development

The early phases of T-cell development require both cell-cell interactions and soluble factors provided by stromal cells within the thymic microenvironment. Still, the precise nature of the signals delivered in vivo by cytokines (resulting in survival, proliferation or differentiation) remains unclear. Recent studies using mice deficient in cytokines or in their receptors have helped to identify essential signaling pathways required for the development of intrathymic precursors to mature alpha beta and gamma delta T cells. In addition, cytokine requirements for the development of natural killer cells were revealed in such mutants. The results obtained demonstrate that the development of all classes of lymphocytes (natural killer, gamma delta T cells and alpha beta T cells) is cytokine dependent, but the specific requirements differ for each lineage.     

Computation of nonlinear functionals in particle methods

We consider the numerical computation of nonlinear functionals of distribution functions approximated by point measures. Two methods are described and estimates for the speed of convergence as the number of points tends to infinity are given. Moreover, numerical results for the entropy functional are presented.     

A route to chaos in a nonlinear oscillator with delay

Summary The paper presents an analysis of the transition from regular to chaotic motion in a Van der Pol-Duffing's oscillator with delay after a Hopf bifurcation. The conditions for the occurrence of the Hopf bifurcation have been determined by means of the approximate method. For the parameters near the bifurcation point a computer simulation of the vibrating system had been performed and the evolution of the system from regular motion to chaos has been analysed at the decrease of the value of the dimensionless damping coefficient.With 2 Figures     

The incorporation of yield surface distortion into a unified constitutive model,part 2: Predictive capabilities

Summary The MATMOD-4V-DISTORTION model has been derived [1] with the intent of improving the MATMOD-4V model by adding the capability to predict distortions of small strain offset yield surfaces. This model is compared against a variety of experimental data to verify its behavior. Model simulations are compared with experimental data for proportional and nonproportional prestress histories and the effect of yield definition is also investigated. Finally, the same model which predicts a flattening of the yield surface in space is used to predict a rotation of the yield surface in ₁-₂ coordinates.With 9 Figures     

Stromdichte- und Magnetfeldverteilung bei einer Anordnung aus Platten und vielen parallelen Stromleitern

Übersicht Die vorliegende Arbeit befaßt sich mit der gesamten Stromdichte- und Magnetfeldverteilung in vielen flachen leitenden Platten konstanter Permeabilität, die bei einer Anordnung aus diesen Platten und vielen parallelen stromführenden Leitern angeordnet in mehreren Lagen entsteht. Unter Anwendung der Maxwellschen Differentialgleichungen und durch Einführung des Vektorpotentials werden allgemeine Gleichungen für die Komponenten der magnetischen Induktion im zweidimensionalen Feldraum aufgestellt. Die Stromdichteverteilung in den leitenden Platten, in denen Wirbelströme entstehen, wird aus dem Vektorpotential hergeleitet. Zunächst werden die Platten unendlich lang angenommen und die entsprechenden Gleichungen in Integralform aufgestellt, für deren Lösung die Gauss-Laguerresche Methode angewandt wird. Dann werden die Platten beiderseits durch Eisenwände begrenzt, womit die Gleichungen unter Berücksichtigung der Randbedingungen in Summenform ausgedrückt werden.

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Distribution of current and magnetic field density in flat conductive plates in an array composed from plates and many parallel conductors

Contents In the present research work the overall distribution of current and magnetic field density in many flat plates of constant magnetic permeability has been investigated, which applies to an array composed from the flat plates and many parallel conductors installed in many layers. Use of Maxwell's differential equations and vector potential results in general equations for the components of magnetic density in two dimensional field space. The distribution of current density in the conductive plates, where eddy currents are taken into account, is obtained from the vector potential. Initially the flat plates are considered being of infinite length, and with appropriate arrangement of the boundary conditions, the model applies to flat plates limited to both sides by iron partitions. Examples are given for both cases, where for the plates of infinite length the Gauss-Laguerre method is applied.

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Liste der Symbole A Vektorpotential - B Magnetische Induktion - I ₁ Stromstärke eines Leiters - N ₁ Anzahl der parallelen Leiter - N ₂ Anzahl der parallelen Platten - Permeabilität des Plattenmaterials - _r Relative Permeabilitätskonstante des Plattenmaterials - Leitfähigkeit - b Breite des Hauptstreukanals - i Stromdichte der Platten samt Wirbelströme - h ₁ Höhe der Leiter - a ₁ Breite der Leiterlagen - a Plattendicke - s Breite des Nebenstreukanals - c Abstand der letzten Platte von der Eisenwand - g Plattenhöhe - x, z, , Dimensionen - Q, K Integrationskonstanten - k ganze Zahl     

Health resort treatment of eye diseases caused by ischemia]

The authors discuss the results of ophthalmodynamometric tests used for the assessment of cerebro-retinal vessels reactivity following carbon dioxide baths and "peat collars". An analysis of systemic and local blood pressure in the ophthalmic artery measured with Weigelin and Lobstein technique enables to assess changes in blood pressures following a/m balneologic procedures. It was found that blood pressure does not change parallelly due to the mechanism of cerebral autoregulation. Transient decrease in blood pressure in the ophthalmic artery is produced by the dilatation of the internal carotid artery indicating a potent vasodilating action of carbon dioxide.     

A combinatorial study of the rigidity of planar structures

Summary A combinatorial method is presented for examining the rigidity of planar structures. In this approach, an expansion process is used for the formation of a statically determinate substructure, known as a -tree of a structure. The algorithm of Lováz and Yemini, and the method of Sugihara are employed for the recognition of the elementary subgraphs, during this process.With 4 Figures     

Effect of mixing leaves with olives on organoleptic quality of oil obtained by centrifugation

Variable quantities of leaves were added to ripe olives prior to extraction to determine their effect on the quality of the resulting olive oil. The addition of 1–3% w/w leaves improved the organoleptic quality. An increase intrans-2-hexenal aldehyde content occurred, giving the pleasant flavor of “freshly cut grass.” This compound was produced by the enzymatic breakdown of 13-L-hydroperoxide of linolenic acid in leaf homogenates.     

高强度高压绝缘子产品质量同其结构性能的重要关系(续)——制造者和用户应共同掌握的规则和指标(第二部分)

6　各种电瓷结构分析实例证实结构的差别下面介绍各种电瓷结构分析的结果。从扫描电镜照片 (ＲＥＭ)的判读中可见到这些材料的差别。试样ａ:日本瓷绝缘子Ｃ1 1 0 /1 1 2 ,制造年代 1 997试样ｂ :西门子瓷绝缘子Ｃ1 2 0 ,Ｃ1 3 0 ,制造年代 2 0 0 1试样ｃ:高强度矾土瓷绝缘子 ,西门子 2 0 0 1开发陶瓷岩相试样的制备系经多级金刚石研磨和抛光以及化学浸蚀。为判定气孔状态 ,对磨片作了透光照片 ,在其光亮区放大倍数为 1 0 0∶1 ,而且扫描电镜照片放大倍数为2 0 0∶1。图 5ａ　试样ａ光片的ＬＭ(透光显微镜 )和ＲＥＭ(扫描电镜 )图象 ,放大倍…