Application potential of bone marrow mesenchymal stem cell (BMSCs) based tissue-engineering for spinal cord defect repair in rat fetuses with spina bifida aperta

Spina bifida aperta are complex congenital malformations resulting from failure of fusion in the spinal neural tube during embryogenesis. Despite surgical repair of the defect, most patients who survive with spina bifida aperta have a multiple system handicap due to neuron deficiency of the defective spinal cord. Tissue engineering has emerged as a novel treatment for replacement of lost tissue. This study evaluated the prenatal surgical approach of transplanting a chitosan–gelatin scaffold seeded with bone marrow mesenchymal stem cells (BMSCs) in the healing the defective spinal cord of rat fetuses with retinoic acid induced spina bifida aperta. Scaffold characterisation revealed the porous structure, organic and amorphous content. This biomaterial promoted the adhesion, spreading and in vitro viability of the BMSCs. After transplantation of the scaffold combined with BMSCs, the defective region of spinal cord in rat fetuses with spina bifida aperta at E20 decreased obviously under stereomicroscopy, and the skin defect almost closed in many fetuses. The transplanted BMSCs in chitosan–gelatin scaffold survived, grew and expressed markers of neural stem cells and neurons in the defective spinal cord. In addition, the biomaterial presented high biocompatibility and slow biodegradation in vivo. In conclusion, prenatal transplantation of the scaffold combined with BMSCs could treat spinal cord defect in fetuses with spina bifida aperta by the regeneration of neurons and repairmen of defective region.     

Large deformation measurement by holographic interferometry

Summary The use of holographic interferometry for the measurement of large deformations is described. From the nature of holographic interferometry it is evident that large deformations exceed the wave length of the light source used by at least ten times of this size. To obtain holographically identifiable values of large deformations, a method of successive partial lighting is used. It shows how it is possible to keep all the advantages of the holographic method and use it even under conditions which apparently exceed its possibilities of application.     

基于改进傅里叶描绘子的CBIR系统

在现有的基于傅里叶描绘子的CBIR系统中,为了提高检索速度,一般需要舍去物体轮廓经傅里叶变换后的大部分高频分量.当物体轮廓在细节部分具有较高能量时,此方法不具备有效性.为尽可能保证检索准确率并兼顾检索速度,在原有傅里叶描绘子上进行扩展,避免直接舍去高频分量,引入Fisher判别分析法将描绘子映射到子空间进行降维,并保证...     

WI – Call for PapersHeft 3/2010High-Impact Requirements Engineering

Ohne Zusammenfassung This article is also available in English via http://www.springerlink.com and http://www.bise-journal.org: BISE – Call for Papers, Issue 3/2010, High-Impact Requirements Engineering. Bus Inf Syst Eng. doi: .     

Integrationsdefizite des IT-Controllings

Zusammenfassung  Der Beitrag basiert auf der Annahme, dass das IT-Controlling in zweifacher Hinsicht unter einem Integrationsdefizit leidet. Dies gilt zum einen für die unbefriedigende Synchronisation der Forschung mit Entwicklungen in der Praxis, zum anderen für die unzureichende Verzahnung mit den Methoden der Wirtschaftsinformatik. Ausgehend von dieser Annahme untersucht der Beitrag die historische Entwicklung des IT-Controllings, um daraus Thesen zum Integrationsstand abzuleiten. Die Untersuchung kommt zu dem Ergebnis, dass Hinweise auf – nach wie vor – ungenutzte Integrationspotenziale vorliegen und identifiziert Potenziale einer weiter gehenden Integration. Aus der Analyse identifizierter Integrationspotenziale werden Anforderungen an eine methodenbezogene Integration abgeleitet und die Realisierung von Integrationspotenzialen an zwei Beispielen illustriert. This article is also available in English via and : Strecker S, Kargl H (2009) Integration Deficits of IT Controlling – Historical Background, Analysis of Integration Potentials and Method Integration. Bus Inf Syst Eng. doi: 10.1007/s12599-009-0053-4.     

Group interaction analysis in dynamic context.

Computer understanding of human actions and interactions is one of the key research issues in human computing. In this regard, context plays an essential role in semantic understanding of human behavioral and social signals from sensor data. This paper put forward an event-based dynamic context model to address the problems of context awareness in the analysis of group interaction scenarios. Event-driven multilevel dynamic Bayesian network is correspondingly proposed to detect multilevel events, which underlies the context awareness mechanism. Online analysis can be achieved, which is superior over previous works. Experiments in our smart meeting room demonstrate the effectiveness of our approach.     

Nonsingular BEM formulations for thin-walled structures and elastostatic crack problems

Summary This paper presents a unique approach, named mathematical regularization, to remove the nearly-singular and singular integrals occurring in the boundary integral formulations for the solution of the boundary value problems with a pathologica integration boundary due to the very near or coinciding parts of the total boundary. Nonsingular boundary integral equations are derived for thin-walled structure problems. In the case of crack-like problems, we present two kinds of the nonsingular integral representations of the secondary fields and the derivative boundary integral equations.     

Lagegeregelte servoantriebe ohne mechanische sensoren

Mechanische Sensoren zur Drehzahl- und Lageerfassung bei elektrischen Antrieben verursachen Kosten, vergrößern das Bauvolumen des Antriebs, bedingen die Datenübertragung zwischen Regler und Sensor und schränken das Einsatzgebiet des Antriebs ein. Daher wurden verschiedene Konzepte zum Ersatz dieser mechanischen Sensoren entwickelt. Sie unterscheiden sich durch den Aufwand, die benötigte Genauigkeit (Pumpenantrieb Servoantrieb) und dem gewünschten Betriebsbereich.In diesem Beitrag wird die Realisierung des sensorlosen Betriebs einer permanenterregten Synchronmaschine durch ein Kalman-Filter beschrieben. Durch Simulation und durch praktische Untersuchungen konnte gezeigt werden, daß die Schätzung von Lage und Drehzahl die Genauigkeitsanforderungen für eine indirekte Lageregelung erfüllt. Eine solche Lageregelung besitzt keinen mechanischen Sensor mehr.