喷油煤浆泵柱塞弹簧抗疲劳断裂研究

分析了喷油煤浆泵柱塞弹簧的疲劳断裂原因,建立了其抗疲劳强度的数学模型,并根据喷油煤浆泵柱塞的工作特点和材料性能,提出了一种新的柱塞弹簧的可靠性设计方法。最后根据新的设计方法对某一型号的柱塞弹簧进行可靠性计算。     

State-of-the-Art on Wound Vitality Evaluation: A Systematic Review

The vitality demonstration refers to determining if an injury has been caused ante- or post-mortem, while wound age means to evaluate how long a subject has survived after the infliction of an injury. Histology alone is not enough to prove the vitality of a lesion. Recently, immunohistochemistry, biochemistry, and molecular biology have been introduced in the field of lesions vitality and age demonstration. The study was conducted according to the preferred reporting items for systematic review (PRISMA) protocol. The search terms were “wound”, “lesion”, “vitality”, “evaluation”, “immunohistochemistry”, “proteins”, “electrolytes”, “mRNAs”, and “miRNAs” in the title, abstract, and keywords. This evaluation left 137 scientific papers. This review aimed to collect all the knowledge on vital wound demonstration and provide a temporal distribution of the methods currently available, in order to determine the age of lesions, thus helping forensic pathologists in finding a way through the tangled jungle of wound vitality evaluation.     

GANAB and N-Glycans Substrates Are Relevant in Human Physiology,Polycystic Pathology and Multiple Sclerosis: A Review

Glycans are one of the four fundamental macromolecular components of living matter, and they are highly regulated in the cell. Their functions are metabolic, structural and modulatory. In particular, ER resident N-glycans participate with the Glc₃Man₉GlcNAc₂ highly conserved sequence, in protein folding process, where the physiological balance between glycosylation/deglycosylation on the innermost glucose residue takes place, according GANAB/UGGT concentration ratio. However, under abnormal conditions, the cell adapts to the glucose availability by adopting an aerobic or anaerobic regimen of glycolysis, or to external stimuli through internal or external recognition patterns, so it responds to pathogenic noxa with unfolded protein response (UPR). UPR can affect Multiple Sclerosis (MS) and several neurological and metabolic diseases via the BiP stress sensor, resulting in ATF6, PERK and IRE1 activation. Furthermore, the abnormal GANAB expression has been observed in MS, systemic lupus erythematous, male germinal epithelium and predisposed highly replicating cells of the kidney tubules and bile ducts. The latter is the case of Polycystic Liver Disease (PCLD) and Polycystic Kidney Disease (PCKD), where genetically induced GANAB loss affects polycystin-1 (PC1) and polycystin-2 (PC2), resulting in altered protein quality control and cyst formation phenomenon. Our topics resume the role of glycans in cell physiology, highlighting the N-glycans one, as a substrate of GANAB, which is an emerging key molecule in MS and other human pathologies.     

Genomic and Immunological Characterization of Hypermucoviscous Carbapenem-Resistant Klebsiella pneumoniae ST25 Isolates from Northwest Argentina

In recent years, an increase in the prevalence hypermucoviscous carbapenem-resistant Klebsiella pneumoniae with sequence type 25 (ST25) was detected in hospitals of Tucuman (Northwest Argentina). In this work, the virulence and the innate immune response to two K. pneumoniae ST25 strains (LABACER 01 and LABACER 27) were evaluated in a murine model after a respiratory challenge. In addition, comparative genomics was performed with K. pneumoniae LABACER01 and LABACER27 to analyze genes associated with virulence. Both LABACER01 and LABACER27 were detected in the lungs of infected mice two days after the nasal challenge, with LABACER01 counts significantly higher than those of LABACER27. Only LABACER01 was detected in hemocultures. Lactate dehydrogenase (LDH) and albumin levels in bronchoalveolar lavage (BAL) samples were significantly higher in mice challenged with LABACER01 than in LABACER27-infected animals, indicating greater lung tissue damage. Both strains increased the levels of neutrophils, macrophages, TNF-α, IL-1β, IL-6, KC, MCP-1, IFN-γ, and IL-17 in the respiratory tract and blood, with the effect of LABACER01 more marked than that of LABACER27. In contrast, LABACER27 induced higher levels of IL-10 in the respiratory tract than LABACER01. Genomic analysis revealed that K. pneumoniae LABACER01 and LABACER27 possess virulence factors found in other strains that have been shown to be hypervirulent, including genes required for enterobactin (entABCDEF) and salmochelin (iroDE) biosynthesis. In both strains, the genes of toxin–antitoxin systems, as well as regulators of the expression of virulence factors and adhesion genes were also detected. Studies on the genetic potential of multiresistant K. pneumoniae strains as well as their cellular and molecular interactions with the host are of fundamental importance to assess the association of certain virulence factors with the intensity of the inflammatory response. In this sense, this work explored the virulence profile based on genomic and in vivo studies of hypermucoviscous carbapenem-resistant K. pneumoniae ST25 strains, expanding the knowledge of the biology of the emerging ST25 clone in Argentina.     

Twenty‐five years of the Information Systems Journal: A bibliometric and ontological overview

The Information Systems Journal (ISJ) published its first issue in 1991, and in 2015, the journal celebrated its 25th anniversary. This study presents an overview of the leading research trends in the papers that the journal has published during its first quarter of a century via a bibliometric and ontological analysis. From a bibliometric perspective, the analysis considers the publication and citation structure of the journal. The study then develops a graphical analysis of the bibliographic material by using visualization of similarities software that employs bibliographic coupling and cocitation analysis. The work produces an ontological framework of impact and analyses the journal papers to assess qualitatively ISJ's impact. The results indicate that the journal has grown significantly over time and is now recognized as one of the leading journals in information systems. Yet challenges remain if the journal is to meet its aims in impacting and setting the agenda for the development of the Information Systems field.     

Enhancing augmented reality with cognitive and knowledge perspectives: a case study in museum exhibitions

ABSTRACT

In this paper, we present our results related to the definition of a methodology that combines augmented reality (AR) with semantic techniques for the creation of digital stories associated with museum exhibitions. In contrast to traditional AR approaches, we augment real-world elements by supplementing contents of a museum exhibition with additional inputs that provide new and different meanings. In this way we augment a cultural resource with respect to both its presentation and meaning. The methodology is framed in the cultural re-mediation theory and is grounded on a set of ontologies aimed at modelling a cultural resource and correlating it with external multimedia objects and resources. To provide an easy tool for the creation of museum narratives, the methodology makes use of a set of recognised practices widely adopted by museum curators that have been formalised through inference rules. The defined methodology has been experimented in a scenario related to Flemish paintings to validate the augmentation of cultural objects with two different approaches, the first basing on similarities and the second on dissimilarities.     

强激光的计算模拟:平顶高斯光束模型

基于广义惠更斯－菲涅耳衍射积分,将平顶高斯光束作为一个整体光束,对其基本性质和变换特性作了统一研究。推导出了平顶高斯光束通过有线性增益（损耗）的近轴ABCD光学系统、无光阑和有光阑ABCD光学系统后解析形式的传输方程。对平顶高斯光束的相似变换以及与超高斯光束的一致性也作了分析。所得结果对强激光的模拟提供了一个有用的计算模型。     

反应物量对纳米晶Fe_3Al组织和性能的影响

利用铝热反应熔化方法分别在反应物量为50、100、200g的条件下制备了块体纳米晶Fe3Al材料,通过TEM和XRD研究了材料的晶粒尺寸,并研究了材料室温压缩性能和硬度。结果表明,所制备的材料主要由非晶和纳米晶组织组成,当反应物量增大,部分区域甚至出现微米晶组织。反应物量为50g时Fe3Al材料中非晶较多,不存在微米晶;反应物量为100g时主要以纳米晶为主,非晶数量减少,伴随有少量的微米晶出现;反应物量为200g时,材料以纳米晶为主,微米晶数量较100g时有所增加。随着反应物量的增加,纳米晶相的平均晶粒尺寸增加,屈服强度和硬度呈先增大后减小的趋势。     

CCD focal-plane image reorganization processors for lossless imagecompression

Four image reorganization ICs that enable real-time difference encoding for hierarchical lossless image compression are reported. Two image reorganization processors are realized on the focal-plane and two are designed for hybridization to a separate imager IC. The two focal-plane ICs represent the first integration of a 256×256 buried-channel frame-transfer CCD image sensor with additional charge-domain circuitry to enable image reformatting at video rates (28 frames/s). The four ICs generate pyramidal pixel output in 3×3 blocks with the center pixel first. Pixel data reorganization is performed through simultaneous readout of three rows of data, followed by pixel resequencing and sampling to provide differential output. A novel architecture provides simultaneous readout of multiple imager rows on the focal-plane ICs. The ICs have achieved a charge-transfer efficiency (CTE) of 0.99996 in the conventional horizontal and vertical CCD registers, and a CTE of 0.99994 in the SP³ registers