全文获取类型
收费全文 | 2576篇 |
免费 | 145篇 |
国内免费 | 3篇 |
专业分类
电工技术 | 30篇 |
综合类 | 5篇 |
化学工业 | 695篇 |
金属工艺 | 37篇 |
机械仪表 | 43篇 |
建筑科学 | 114篇 |
矿业工程 | 10篇 |
能源动力 | 105篇 |
轻工业 | 187篇 |
水利工程 | 28篇 |
石油天然气 | 5篇 |
无线电 | 229篇 |
一般工业技术 | 467篇 |
冶金工业 | 152篇 |
原子能技术 | 9篇 |
自动化技术 | 608篇 |
出版年
2024年 | 4篇 |
2023年 | 43篇 |
2022年 | 140篇 |
2021年 | 133篇 |
2020年 | 80篇 |
2019年 | 82篇 |
2018年 | 100篇 |
2017年 | 84篇 |
2016年 | 103篇 |
2015年 | 88篇 |
2014年 | 116篇 |
2013年 | 189篇 |
2012年 | 142篇 |
2011年 | 226篇 |
2010年 | 142篇 |
2009年 | 136篇 |
2008年 | 172篇 |
2007年 | 118篇 |
2006年 | 107篇 |
2005年 | 73篇 |
2004年 | 50篇 |
2003年 | 56篇 |
2002年 | 37篇 |
2001年 | 28篇 |
2000年 | 31篇 |
1999年 | 23篇 |
1998年 | 50篇 |
1997年 | 45篇 |
1996年 | 28篇 |
1995年 | 18篇 |
1994年 | 16篇 |
1993年 | 11篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1989年 | 5篇 |
1988年 | 8篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1983年 | 1篇 |
1982年 | 5篇 |
1981年 | 2篇 |
1980年 | 4篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1976年 | 1篇 |
1975年 | 2篇 |
排序方式: 共有2724条查询结果,搜索用时 15 毫秒
101.
102.
Cold groundwater temperatures and conductive heat flow in the Mt. Amiata geothermal area, Tuscany, Italy 总被引:1,自引:0,他引:1
Giovanni Chiodini Paola Comodi Stefano Giaquinto Bruno Mattioli Anna Rosa Zanzari 《Geothermics》1988,17(4)
The hydrogeochemical study of the cold springs present in the Mt. Amiata geothermal area, where the Bagnore and Piancastagnaio geothermal fields are situated, has defined the different shallow groundwater systems.The cold groundwater temperature of the volcanic phreatic aquifer is largely correlated with the geothermal heat flow. Through the analysis of the temperature of cold groundwaters, a possible method for geothermal prospection has been developed, supported by the results obtained in the studied area. Through the enthalpic balance of the aquifer and in agreement with available data, a geothermal flow of about 200 mW m-2 has been calculated. 相似文献
103.
104.
Simonetta Pazzaglia Barbara Tanno Ilaria De Stefano Paola Giardullo Simona Leonardi Caterina Merla Gabriele Babini Seda Tuncay Cagatay Ammar Mayah Munira Kadhim Fiona M. Lyng Christine von Toerne Zohaib N. Khan Prabal Subedi Soile Tapio Anna Saran Mariateresa Mancuso 《International journal of molecular sciences》2022,23(4)
Cell communication via exosomes is capable of influencing cell fate in stress situations such as exposure to ionizing radiation. In vitro and in vivo studies have shown that exosomes might play a role in out-of-target radiation effects by carrying molecular signaling mediators of radiation damage, as well as opposite protective functions resulting in resistance to radiotherapy. However, a global understanding of exosomes and their radiation-induced regulation, especially within the context of an intact mammalian organism, has been lacking. In this in vivo study, we demonstrate that, compared to sham-irradiated (SI) mice, a distinct pattern of proteins and miRNAs is found packaged into circulating plasma exosomes after whole-body and partial-body irradiation (WBI and PBI) with 2 Gy X-rays. A high number of deregulated proteins (59% of WBI and 67% of PBI) was found in the exosomes of irradiated mice. In total, 57 and 13 miRNAs were deregulated in WBI and PBI groups, respectively, suggesting that the miRNA cargo is influenced by the tissue volume exposed to radiation. In addition, five miRNAs (miR-99b-3p, miR-200a-3p, miR-200a, miR-182-5p, miR-182) were commonly overexpressed in the exosomes from the WBI and PBI groups. In this study, particular emphasis was also given to the determination of the in vivo effect of exosome transfer by intracranial injection in the highly radiosensitive neonatal cerebellum at postnatal day 3. In accordance with a major overall anti-apoptotic function of the commonly deregulated miRNAs, here, we report that exosomes from the plasma of irradiated mice, especially in the case of WBI, prevent radiation-induced apoptosis, thus holding promise for exosome-based future therapeutic applications against radiation injury. 相似文献
105.
Francesca Bugli Federica Massaro Francesco Buonocore Paolo Roberto Saraceni Stefano Borocci Francesca Ceccacci Cecilia Bombelli Maura Di Vito Rosalba Marchitiello Melinda Mariotti Riccardo Torelli Maurizio Sanguinetti Fernando Porcelli 《International journal of molecular sciences》2022,23(4)
The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications are lipopeptides, linear antimicrobial peptides (AMPs) conjugated to a lipid tail, usually at the N-terminus. In this paper, we investigated the in vitro and in vivo antifungal activity of three short myristoylated and non-myristoylated peptides derived from a mutant of the AMP Chionodracine. We determined their interaction with anionic and zwitterionic membrane-mimicking vesicles and their structure during this interaction. We then investigated their cytotoxic and hemolytic activity against mammalian cells. Lipidated peptides showed a broad spectrum of activity against a relevant panel of pathogen fungi belonging to Candida spp., including the multidrug-resistant C. auris. The antifungal activity was also observed vs. biofilms of C. albicans, C. tropicalis, and C. auris. Finally, a pilot efficacy study was conducted on the in vivo model consisting of Galleria mellonella larvae. Treatment with the most-promising myristoylated peptide was effective in counteracting the infection from C. auris and C. albicans and the death of the larvae. Therefore, this myristoylated peptide is a potential candidate to develop antifungal agents against human fungal pathogens. 相似文献
106.
107.
108.
A study of the feasibility of providing the heating and cooling needs of the new, large commercial building near Turin, Italy, by means of an open-loop indirect groundwater heat pump (GWHP) system is described. A finite element subsurface flow and transport simulator (FEFLOW) was used to investigate possible configurations of extraction and injection wells for five different scenarios. Modelling results confirmed the hydrogeological capacity of the site to provide the necessary amount of groundwater and associated energy with limited environmental impact. Injection of warmer (or cooler) water in the aquifer creates a thermal plume whose dimensions and geometry depend on the properties of the subsurface formations, particularly their thermal dispersivity values. The study suggests that there are several possible well configurations that could support the GWHP system without adversely affecting the aquifer. 相似文献
109.
Ilaria Venanzi Oren Lavan Laura Ierimonti Stefano Fabrizi 《Structure and Infrastructure Engineering》2018,14(10):1295-1311
This paper presents a framework for life-cycle loss estimation for non-structural damage in tall buildings under wind and seismic loads. Life-cycle cost analysis is a useful design tool for decision- makers, aimed at predicting monetary losses over the lifetime of a structure, accounting for uncertainties involved in the problem definition. For tall buildings, sensitive to dynamic excitations like earthquake and wind, it can be particularly suitable to base design decisions not only on initial cost and performance but also on future repair expenses. The proposed approach harmonises the procedures for intervention costs evaluation of structures subjected to multiple-hazards, taking into account the peculiar differences of wind and earthquake, in terms of load characterisation, type and evolution of damage. Relative effect of the two hazards on damage to drift- and acceleration-sensitive non-structural elements are examined. The influence of uncertainty in structural damping is also taken into account. It is shown that, although it is commonly believed that the design of a given structure is usually dominated by either winds or earthquakes, when LCC-based design is performed, both winds and earthquakes may be important. 相似文献
110.