Serum IgA antibodies from patients with coeliac disease react strongly with human brain blood-vessel structures

BACKGROUND: Our objective was to determine the possible presence of IgA antibodies directed against human central nervous system (CNS) structures in sera from coeliac disease (CD) patients. METHODS: Serum samples were collected from 4 patients with active CD on a gluten-containing diet, 11 biopsy-proven CD patients on a gluten-free diet (GFD), and 52 non-coeliac gastrointestinal controls. In all patients IgA antigliadin antibody (AGA) titres were determined with enzyme-linked immunoassay (ELISA), and IgA antiendomysium antibodies (EMA) with indirect immunofluorescence on human umbilical cord. Cryostat sections of human brain occipital cortex were incubated with the patients' sera and subsequently labelled with anti-human IgA fluorescein conjugate. RESULTS: All sera from patients with active CD on a gluten-containing diet yielded positive results in both the IgG-AGA and EMA test and in indirect immunofluorescence on brain tissue, disclosing a strong fluorescence over blood-vessels structures. All sera from CD patients on a GFD and from non-coeliac gastrointestinal controls gave a negative result on both the EMA test and the immunofluorescence reaction on human brain. CONCLUSIONS: Sera from patients with active CD contain IgA antibodies that react with human brain vessel structures, giving intense fluorescence. These antibodies are not present in sera from coeliac patients on a GFD or non-coeliac controls. This finding might be involved in the abnormal nervous system manifestations frequently described in association with coeliac disease.     

Microwave cavity perturbation technique: Part I: Principles

This report reviews the analysis used to extract the complex conductivity of a compound from a microwave cavity perturbation measurement. We intend to present a generalized treatment valid for any spheroidally shaped sample of arbitrary conductivity which is placed at either the electric or magnetic field antinode of the cavity. To begin with, we establish the relationship between the measured parameters and the conductivity for a spherical sample. Next, we extend these results to the case of spheroids; and for the first time, we cover all different configurations that one can possibly use to study an arbitrary conducting sample inside a cavity: in particular, all possible orientations of the sample with respect to the applied field are solved.     

LDMOS射频晶体管满足2.5G和3G蜂窝基站的新挑战

运行在869MHz-2.17GHz频段内的蜂窝无线基站是射频功率晶体替如今最大的市场。其中，基中硅的LDMOS器件被广泛使用于500MHz=2.5GHz之间的射频功率放大器应用当中。作为增强模式的N沟道MOSFET，LDMOS器件(LD代表侧面扩散，描述了器件的沟道结构)专门被设计成为具有高的工作电压(长沟道）和低寄生电容，从而能在高频下工作。在早     

The feasibility of smoking bans on psychiatric units

Cryptococcal meningitis has a high mortality rate of central nervous infection. The patients usually die of the disease itself, or complications from increased intracranial pressure. Early diagnosis and treatment, including surgical drainage, will improve the results. In this series, twenty-one patients with high intracranial pressure (ICP > 300 mmH2 O) are presented. Fourteen received implantation of Ommaya reservoir to aspirate cerebrospinal fluid (CSF) for relief of symptoms of ICP. Meanwhile 4 of these 14 patients also received intraventricular injection of amphotericin B because of poor response to systemic drugs. Another seven patient received systemic drug therapy only. Survival during therapy occurred in 11 of 14 patients in the surgical group, compared with only 1 of 7 patients treated by drug therapy alone (P = 0.019). In the 14 patients who received implantation of an Ommaya reservoir, there was one complication of CSF leakage when the reservoir ruptured because of repeated aspiration. For patients with cryptococcal meningitis with high ICP, early implantation of an Ommaya reservoir will improve the survival rate.     

Ergodic properties of computer orbits for simple piecewise monotonic transformations

Using a general model for normalized floating point arithmetic, we study the computer generated orbit of simple piecewise monotonic transformations on [0, 1] of the form τ(x) = kx(mod 1). Conditions under which the computer orbit is eventually exact are established. Moreover it is shown that for sufficiently high precision of computation the computer orbits display the same ergodic properties as the exact orbits of the transformations.     

Detecting memory impairment with a modified test procedure: Manipulating retention interval with centrally presented event items.

Suggests that detecting memory impairment with the modified test relies on long retention intervals that provide the necessary forgetting of event information for impairing effects of postevent misinformation to occur. 288 Ss were tested in 4 experiments that presented event items centrally, introduced verbal postevent items to a misled condition, and used the modified test, but differed by using either short (15 min) or long (5–7 days) retention intervals. As evidenced by poorer misled than control test performances, memory impairment only occurred with long retention intervals. Retrieval- and storage-based versions of memory-impairment hypotheses are assessed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

On the nature of self-monitoring: Matters of assessment, matters of validity.

Notes that an extensive network of empirical relations has been identified in research on the psychological construct of self-monitoring. Nevertheless, in recent years some concerns have been expressed about the instrument used for the assessment of self-monitoring propensities, the Self-Monitoring Scale (SMS) developed by the 1st author (see record 1975-03047-001). Both the extent to which the SMS taps an interpretable and meaningful causal variable and the extent to which the self-monitoring construct provides an appropriate theoretical understanding of this causal variable have been questioned. An examination of reanalyses of studies of self-monitoring, analyses of the internal structure of the SMS, and further relevant data suggests that the measure does tap a meaningful and interpretable causal variable with pervasive influences on social behavior, a variable reflected as a general self-monitoring factor. The evaluation and furthering of the interpretation of this latent causal variable are discussed, criteria for evaluating alternative measures of self-monitoring are offered, and a new 18-item SMS is presented. (88 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Clock frequency and latency in synchronous digital systems

The tradeoffs in the design of synchronous digital systems between clock frequency and latency in terms of the circuit characteristics of a pipelined data path are described. A design paradigm relating latency and clock frequency as a function of the level of pipelining is developed for studying the performance of a synchronous system. This perspective permits the development of design equations for constrained and unconstrained design problems which describe these performance parameters in terms of the delays of the logic, interconnect, registers, clock skew, and the number of logic states. These results provide an approach to the design of those synchronous digital systems in which latency and clock frequency are of primary importance. From the behavioral specifications for the proposed system, the designer can use these results to select the best logic architecture and the best available device technology to determine if the performance specifications can be satisfied, and, if so, what design options are available for optimization of other system attributes, such as area     

Dynamic Policy-Based Network Management for a Secure Coalition Environment

This article reports the latest results of an R&D effort to develop a prototype implementation of a dynamic policy-based network management (PBNM) system that can be used to configure and manage a secure network for a coalition environment across an unsecured wide area network. The prototype, based on a distributed architecture, includes capabilities for policy creation and management, dynamic policy negotiation, and dynamic policy provisioning. The policy negotiation facilitates the rapid deployment of a coalition network while the dynamic policy provisioning automates the configuration and management of network services including firewalls, virtual private network connections, routing, quality of service (QoS), and domain name services. Such a PBNM system enhances an organization's ability to react to network incidents identified by a network situational awareness assessment. Although the focus of the current research is a military coalition environment, the system can be used in any distributed enterprise or collaborative environment