Pectic Galactan Polysaccharide-Based Gene Delivery System for Targeting Neuroinflammation

Treating neuroinflammation-related injuries and disorders through manipulation of neuroinflammation functions is being heralded as a new therapeutic strategy. In this study, a novel pectic galactan (PG) polysaccharide based gene therapy approach is developed for targeting reactive gliosis in neuroinflammation. Galectin-3 (Gal-3) is a cell protein with a high affinity to β-galactoside sugars and is highly expressed in reactive gliosis. Since PG carries galactans, it can target reactive gliosis via specific carbohydrate interaction between galactan and Gal-3 on the cell membrane, and therefore can be utilized as a carrier for delivering genes to these cells. The carrier is synthesized by modifying quaternary ammonium groups on the PG. The resulting quaternized PG (QPG) is found to form complexes with plasmid DNA with a mean diameter of 100 nm and have the characteristics required for targeted gene therapy. The complexes efficiently condense large amounts of plasmid per particle and successfully bind to Gal-3. The in vivo study shows that the complexes are biocompatible and safe for administration and can selectively transfect reactive glial cells of an induced cortical lesion. The results confirm that this PG-based delivery system is a promising platform for targeting Gal-3 overexpressing neuroinflammation cells for treating neuroinflammation-related injuries and neurodegenerative diseases.     

Analysis of external latch-up protection test structure design using numerical simulation

With each new CMOS technology the latch-up sensitivity and effects of prevention strategies change. Products built in these technologies must adhere to stringent guidelines for latch-up ‘Hardness’, and for this reason characterisation of new technologies is needed through the use of test structures. This paper shows a numerical simulation approach which can determine the relative effectiveness of guard-rings in ESD protection device test structures. In this work, time taken to characterise latch-up protection test structures and to chose a protection strategy is greatly reduced by using numerical simulations to design the test structures. The results presented are for variations to the guard-rings for two technologies. Included in these are the typical simulation times and resources required. The technique outlined has the joint advantages of providing accurately representative simulations of the technology and test structure layout in a practical time frame.     

Effects of CW Interference on the Carrier Tracking Loop of the Deep Space Network

The effects of CW interference on a phase-locked loop (PLL) have been examined in many papers. None of these included the effects of a bandpass limiter (BPL) preceding the phase-locked loop. This paper extends some of those analyses to include the effects of a BPL and applies the results to the carrier tracking loop of a Deep Space Network (DSN) receiver, which employs a second-order phase-locked loop preceded by a BPL. The DSN receiver is used for deep space communications and is often subject to potential interference. Experimental data and computer simulation results are presented.     

VE-mobicast: a variant-egg-based mobicast routing protocol for sensornets

In this paper, we present a new “spatiotemporal multicast”, called a “mobicast”, protocol for supporting applications which require spatiotemporal coordination in sensornets. The spatiotemporal character of a mobicast is to forward a mobicast message to all sensor nodes that will be present at time t in some geographic zone (called the forwarding zone) Z, where both the location and shape of the forwarding zone are a function of time over some interval (t _start ,t _end ). The mobicast is constructed of a series of forwarding zones over different intervals (t _start ,t _end ), and only sensor nodes located in the forwarding zone in the time interval (t _start ,t _end ) should be awake in order to save power and extend the network lifetime. Existing protocols for a spatiotemporal variant of a multicast system were designed to support a forwarding zone that moves at a constant velocity, , in sensornets. To consider the path of a mobile entity which includes turns, this work mainly develops a new mobicast routing protocol, called the variant-egg-based mobicast (VE-mobicast) routing protocol, by utilizing the adaptive variant-egg shape of the forwarding zone to achieve high predictive accuracy. To illustrate the performance achievement, a mathematical analysis is conducted and simulation results are examined. Yuh-Shyan Chen received the M.S. and Ph.D. degrees in Computer Science and Information Engineering from the National Central University, Taiwan, Republic of China, in June 1991 and Jan. 1996, respectively. He joined the faculty of Department of CSIE, Chung-Hua University, Taiwan, in 1996. He joined the Department of Statistic, National Taipei University in Aug. 2000, and joined the Department of CSIE, National Chung Cheng University in Aug. 2002. Dr. Chen is an associate Professor from Aug. 2003. Since 2006, he has been a Professor at the Department of CSIE, National Taipei University, Taiwan. Dr. Chen served as Co-Editors-in-Chief of International Journal of Ad Hoc and Ubiquitous Computing (IJAHUC); Editorial Board Member of Telecommunication System; Guest Editor of Telecommunication Systems, special issue on “Wireless Sensor Networks” (2004). He was a Vice Co-Chair, Wireless IP Symposium of WirelressCOM, USA (2005); Workshop Co-Chair, IEEE AHUC06, Taiwan (2006); Program Co-Chairs, IFIP NCUS06, Korea (2006). Dr. Chen also served as Program Committee Member of ICPP’03, ICDCS’04, ICCCN’01–06, MSN’05, CCN’02–06, CSA’04 06, NCS’06, MSEAT’03–06, WASN06, USN06, MHNET06, PESYS06, ML06, IWWN06, UIC06, ICWMC06, and HWN-RMQ06; IASTED Technical Committee on Telecommunications (2002–2005); WSEAS International Scientific Committee Member (from 2004). His paper wins the 2001 IEEE 15th ICOIN-15 Best Paper Award. Dr. Chen was a recipient of the 2005 Young Scholar Research Award given by National Chung Cheng University to four young faculty members, 2005. His recent research topics include mobile ad-hoc network, wireless sensor network, and 4G system. Dr. Chen is a member of the IEEE Computer Society and Phi Tau Phi Society. Shin-Yi Ann received the B.S. degree in computer science and engineering from the National Taiwan Ocean University, Taiwan, Republic of China, in June 2002 and the M.S. degree in computer science and information engineering from National Chung Cheng University, Taiwan, Republic of China, in July 2004. His research interest includes wireless sensor network. Yun-Wei Lin received the B.S. degree in computer and information science from the Aletheia University, Taiwan, Republic of China, in June 2003 and the M.S. degree in computer science and information engineering from National Chung Cheng University, Taiwan, Republic of China, in July 2005. His research interests include mobile ad hoc network and wireless sensor network.     

80–360 GHz very wide band millimeter wave network analyzer

An extension to a 20 GHz HP8510C Network Analyzer has been built for wideband measurements between 80 and 360 GHz. Improvements relative to the first version [1], [2] include new harmonic mixers, and an active doubler. Dynamic ranges up to 60 dB in transmission and 50 dB in reflection are obtained up to 280 GHz, with more than 50 GHz instantaneous bandwidth using waveguide calibration. Detection with a 30 dB dynamic range is obtained at 320 – 360 GHz. Time domain measurements give spatial resolution down to 2 mm.     

Judge Nonverbal Communication on Trial: Do Mock Trial Jurors Notice?

This study investigated jurors' reactions to judges' nonverbal communication in mock trials. Participants in 80 mock juries viewed taped segments of direct and cross examination that varied the judges' level of nonverbal involvement. Comments about the judge were solicited in predeliberation questionnaires and unsolicited comments obtained from dialogue that occurred during mock jury deliberations. The investigation found that jurors are aware of nonverbal cues from judges, particularly negative behaviors. Although the high- and low-involved judges solicited roughly the same number of comments, more negative comments were made about the judge displaying low than high nonverbal involvement. The results also revealed that jurors made more negative comments than positive ones. Overall, jurors are most aware of a judge's lack of involvement and apparent bias. Discussion focuses on ways to minimize the influence of judge nonverbal communication on jurors.     

Performance Analysis of Downlink W-CDMA Systems in Weibull and Lognormal Fading Channels Using Chaotic Codes

In this paper, a subspace based blind channel estimation scheme for downlink W-CDMA systems using chaotic codes under Weibull and Lognormal fading channel conditions is proposed and compared with W-CDMA system using PN codes. The algorithm provides estimates of multiuser channels by exploiting the structural information of the data output. The subspace of the (data + noise) matrix contains sufficient information for unique determination of channels and, hence, the signature waveforms and signal constellations. The proposed channel estimation algorithm is also implemented for multiuser—orthogonal frequency division multiplexing (OFDM) system. Performance measures like bit error rate (BER) and root mean square error (RMSE) are plotted for Weibull and Lognormal fading channels. Signal constellations under Weibull and Lognormal channels are also plotted. Analytical and Simulation results for BER and RMSE are compared for W-CDMA system using PN codes and chaotic codes. Simulation results show that, chaos-based W-CDMA outperforms the PN-based W-CDMA in terms BER and RMSE. Simulation results of multiuser-OFDM system shows that performance is further improved when compared to the W-CDMA system.     

Schottky barriers on n-GaN grown on SiC

Characteristics of Schottky barriers fabricated on n-type GaN were investigated. The barriers were formed by vacuum thermal evaporation of Cr, Au, and Ni. Current-voltage (I-V) and capacitance-voltage (C-V) characteristics of the barriers were measured in a wide temperature and current density range. Fundamental parameters (barrier height and built-in potential) of the Schottky barriers were determined. The dependence of the barrier ideality factor on doping concentration in GaN was measured. Correlation between the barrier height and metal work function was observed. The electron affinity for GaN was determined using both C-V and I-V characteristics. The current flow mechanism through the barriers is discussed.     

Wearable computers — an application of BT's mobile video system for the construction industry

The construction industry is acknowledged to be heavily dependent on information flow and communications. Electronic communication from one office to another is relatively straightforward with today's technology. However, when one of the parties wishing to communicate is based out on the construction site, problems of remoteness and insufficient infrastructure can limit the effectiveness of their communications. The emergence of wearable computers offers a potential method of improving this situation, particularly when a visual link is provided by a mobile video transmission system.This paper outlines the subject of wearable computers, and describes the use of a mobile video camera in a construction application setting. The system has been used on a live construction project at Brindleyplace in Birmingham. Brindleyplace is currently one of the largest commercial construction projects in Europe.The system is described in detail, followed by some critical comments made by the users of the system. The paper also draws on issues such as possible applications and potential benefits to be gained in the long term. Technology and design issues of the system are also discussed.     

Integratable, high speed buried ridge DFB lasers fabricated on semi-insulating substrates

The fabrication of buried ridge DFB lasers on semi-insulating substrates is described. A novel contacting mechanism was employed to give a series resistance of less than 4 Omega . Devices were fabricated at both 1.3 and 1.53 mu m with lasing thresholds as low as 16 mA. Single longitudinal mode operation was achieved with SMSR greater than 30 dB at both wavelengths. The structure gives an inherently low capacitance, which together with low threshold currents, low series resistance and fabrication on SI substrates makes these devices suitable for integration and high speed applications.<>