Collapse-free thermal bonding technique for large area microchambers in plastic lab-on-a-chip applications

Bonding is an essential step to form microchannels or microchambers in lab-on-a-chip applications. In this paper, we present a novel plastic thermal bonding technique to seal and form large area microchambers (planar characteristic width and length on the order of 1 mm and characteristic thickness on the order of 10–100 μm) without collapse by introducing a holed pressure equalizing plate (HPEP) that includes holes of the same size and shape as the microchambers. To demonstrate the proposed technique, two types of large area microchambers [(1) 20 × 10 mm and 40 μm thick and (2) 12 × 2.5 mm and 120 μm thick] with microchannels were designed and replicated on plastic substrates by means of hot embossing and injection molding processes with prepared two nickel mold inserts. The replicated large area microchambers as well as the microchannels in the plastic lab-on-a-chip were successfully sealed (i.e., no leakage) and formed without any collapse by the proposed thermal bonding technique with the help of the HPEP.     

基于FPGA实现DSP与RapidIO网络互联

本文首先简单的介绍了总线的发展,从而引出一种新型的串行点对点交换结构RapidIO.DSP在高性能处理系统中的重要性毋庸置疑,但是目前的很多DSP并没有RapidlO接口.本文提出了利用FPGA,将DSP的总线桥接到一个RapidIO IP上,从而实现了DSP与RapidIO网络的互联.     

基于模板的SoC结构自动划分方法

针对SoC芯片设计中的系统划分问题,提出一种面向应用的系统结构自动划分方法--基于模板的系统划分方法,并开发了系统划分工具--TBPS.基于模板的系统划分方法通过提取应用描述中的相似结构,并使用相似结构划分系统,最终得到一个尽量复用的系统结构.系统的相似结构划分采用遗传算法实现最优覆盖的搜索,并使用贪婪算法实现资源配置和任务调度.与已有的在系统划分中事先设定目标结构方法不同,文中方法可以根据应用的特点自动生成划分的结构.采用该方法及TBPS实现了应用描述到系统结构的自动划分.实验结果表明了TBPS对数据处理为主的应用划分的有效性.     

蚁群算法及其在路由优化中的应用综述

蚁群算法(ACO)是一类新型的机器学习技术,根据蚁群算法的正反馈原理和启发式原理的特点,针对目前国内国际的研究情况,对蚁群算法在最优路径的搜寻上从收敛性,收敛算法的改进以及收敛速度等方面的研究分别进行了分析综述,并对蚁群算法的一些应用,如:LEO卫星网络和无线传感等方面进行了阐述.对蚁群算法在路由优化和负载平衡上的研究进行了对比分析,发现了它们存在的不足,指出了在该领域需要进一步研究的热点问题.     

一种多总线通讯系统的实现

首先讨论了多总线通讯系统的主从式网络构建方法和通讯MBI的功能;其次给出了多总线通讯系统中总线利用率和总线负载的计算方法以及在系统中时基的应用方法。在此基础上,论述了基于ADSP21060,结合1553B总线和RS-422总线的多总线通讯系统的实现,具体包括硬件接口设计和通讯软件的实现。实验表明,多总线通讯系统适用于外部总线负载小于70%,内部总线负载小于40%的通讯系统,具有普遍意义。     

A data collection protocol for real-time sensor applications

The nature of many sensor applications as well as continuously changing sensor data often imposes real-time requirements on wireless sensor network protocols. Due to numerous design constraints, such as limited bandwidth, memory and energy of sensor platforms, and packet collisions that can potentially lead to an unbounded number of retransmissions, timeliness techniques designed for real-time systems and real-time databases cannot be applied directly to wireless sensor networks. Our objective is to design a protocol for sensor applications that require periodic collection of raw data reports from the entire network in a timely manner. We formulate the problem as a graph coloring problem. We then present TIGRA (Timely Sensor Data Collection using Distributed Graph Coloring) — a distributed heuristic for graph coloring that takes into account application semantics and special characteristics of sensor networks. TIGRA ensures that no interference occurs and spatial channel reuse is maximized by assigning a specific time slot for each node. Although the end-to-end delay incurred by sensor data collection largely depends on a specific topology, platform, and application, TIGRA provides a transmission schedule that guarantees a deterministic delay on sensor data collection.     

高速可配置Rijndael算法的设计与实现

针对网络通信的安全要求,给出了在集成电路设计中实现Rijndael算法的高吞吐率解决方案。对算法实现进行了优化,具有支持密钥长度和数据长度的可变选择与组合配置,加密和解密工作通道完全独立,全双工安全高速通信等特点。已通过了FPGA的验证与电路实现。通过对比分析综合仿真结果,该实现相对于目前已知的实现方案在性能和速度上具有很大的优势。     

Cytotoxicity of aggregated fullerene C60 particles on CHO and MDCK cells

The cytotoxicity of fullerene C60 particles on two mammalian cell lines, i.e. the Chinese hamster ovary (CHO) cells and the Madin-Darby canine kidney (MDCK) cells, has been investigated. Although innate fullerene particles have a very low solubility in deionized (DI) water, these particles can be dissolved in the tetrahydrofuran (THF) solvent at a great value. Further, the dissolved fullerene particles in the THF solvent could be extracted into a DI water solution at a significantly increased solubility. The formation of fullerene particle aggregates is believed to be the cause of the increased solubility. Results presented here show that once the concentration of the fullerene aggregates reaches a certain level, the cells start to die. The lethal dosage LD50, which is defined as the lowest fullerene concentration that results in a 50% cell death within 24 h, has been determined. Furthermore, the percentage of cell mortality increased with increasing fullerene concentration and incubation time yielding a negative effect on cell viability. These results, illustrated by atomic force microscopy (AFM), dynamic light scattering (DLS) and other microscopic techniques, will help to better understand the side effects of fullerene particles in mammalian cells.     

CSE620R分切机退卷控制器参数调校的新方法

文章针对CSE620R分切机退卷张力控制系统过去使用过渡膜调校方法的不足,从理论上对各个需要调校的参数进行理论计算和曲线校对,并将计算结果对控制板进行设定和曲线校对.这既提高了调校精度又达到稳定生产的目的.避免了浪费大量的薄膜和能耗.     

Dijkstra算法在肾脏移植交换系统中的应用

在肾脏移植过程中,经常存在一个病人的亲属愿意将自己的一个肾脏捐赠给此病人,但是他们的肾脏匹配不够好,只能放弃的情况,这明显是一种资源的浪费.一个可行的方案就是肾脏交换系统.在这篇论文中,我们提出了两种解决方法,分别代表了解决此问题的两个解决方向.给一些相应的组织,如美国的OPTN,一定的改进建议,并对其他国家建立类似的组织起到一定的指导作用.