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排序方式： 共有1410条查询结果，搜索用时 15 毫秒
41.
    
Advances in molecular imaging modalities have accelerated the diagnosis and treatment of human diseases. However, tumors less than 1 cm in size still remain difficult to localize by conventional means because of the difficulty in specific targeting/delivery to the tumor site. Furthermore, high nonspecific uptake in the major organs and persistent background retention results in low tumor-to-background ratio. The targeting and therapy of gastrointestinal stromal tumors (GIST) using nonsticky and renal clearable theranostic nanoparticles (a.k.a. H-Dots) are demonstrated. H-Dots not only target GIST for image-guided surgery, but also tailor the fate of anticancer drugs such as imatinib (IM) to the tumor site resulting in efficient treatment of unresectable GIST. In addition, H-Dots can monitor targetability, pharmacokinetics, and drug delivery, while also showing therapeutic efficacy in GIST-bearing xenograft mice following surgical resection. More importantly, IM loaded H-Dots exhibit lower uptake into the immune system, improved tumor selectivity, and increased tumor suppression compared to free IM, which accumulates in the spleen/liver. Precisely designed H-Dots can be used as a promising theranostic nanoplatform that can potentially reduce the side effects of conventional chemotherapies.  相似文献   
42.
    
A transistor is fabricated with a 2D electron gas (2DEG) channel at the Al2O3 (AO)/SrTiO3 (STO) interface. The threshold voltage (Vth) shift of the 2DEG channel in the Pt/AO/2DEG/STO stack induced by negative bias stress is investigated. Two‐terminal current–voltage and capacitance–voltage characterization through the gate and the source reveals that the metallic 2DEG channel turns into a semiconducting channel when the negative bias stress is applied. Transfer curve measurement with various stress conditions on the 2DEG field‐effect transistor is performed to evaluate the effect of the negative bias stress. The Vth becomes positive, and the channel conductance decreases after the application of negative bias stress. These variations are promoted by large stress bias and temperature. Electron energy loss spectroscopy analysis via scanning transmission electron microscopy reveals that the chemical state of the interface changes from oxygen‐deficient to stoichiometric. Therefore, the change in the channel state from metallic to semiconducting originates from the decrease of oxygen vacancy concentration at the interface.  相似文献   
43.
    
In this paper, we propose a novel formulation extending convolutional neural networks (CNN) to arbitrary two-dimensional manifolds using orthogonal basis functions called Zernike polynomials. In many areas, geometric features play a key role in understanding scientific trends and phenomena, where accurate numerical quantification of geometric features is critical. Recently, CNNs have demonstrated a substantial improvement in extracting and codifying geometric features. However, the progress is mostly centred around computer vision and its applications where an inherent grid-like data representation is naturally present. In contrast, many geometry processing problems deal with curved surfaces and the application of CNNs is not trivial due to the lack of canonical grid-like representation, the absence of globally consistent orientation and the incompatible local discretizations. In this paper, we show that the Zernike polynomials allow rigourous yet practical mathematical generalization of CNNs to arbitrary surfaces. We prove that the convolution of two functions can be represented as a simple dot product between Zernike coefficients and the rotation of a convolution kernel is essentially a set of 2 × 2 rotation matrices applied to the coefficients. The key contribution of this work is in such a computationally efficient but rigorous generalization of the major CNN building blocks.  相似文献   
44.
    
The development of transition metal dichalcogenides (TMDCs) and quantum dots (QDs) as the promising semiconductor and emitter is carried out in diverse applications. Despite superb research progress, study of emerging devices incorporated with TMDC thin film transistors (TFTs) and quantum dot light-emitting diodes (QLEDs) is rarely reported. Herein, the QLEDs operation controlled by p (or n-type) molybdenum ditelluride (MoTe2) TFTs with the realization of complementary type transistor is first demonstrated. In this study, molecular doping by poly-L-lysine (PLL) is adopted for a type conversion of MoTe2 TFTs and surface ligand modification is utilized for improvement of QLED performance. As a result, the PLL treatment achieves the outstanding type conversion of MoTe2 TFTs without any degradation of electrical properties, leading to securing reliable n or p-type devices, thus, availability of complementary circuits. Furthermore, ligand modified QDs capped with octylamine result in balanced electron/hole injection in QLEDs, yielding improved current efficiency (ηA = 13.9 cd A−1) and longer lifetimes (T50 = 66 h at L0 = 3000 cd m−2). Lastly, MoTe2 TFTs demonstrate their capabilities to drive the QLEDs for the envisioned application including display backplane transistor with decent switching properties, immunity for generation of photocurrent, and operation stability.  相似文献   
45.
This paper proposes a soft-switching CSI for a photovoltaic power system which has an H-type switched-capacitor module composed of two semiconductor switches, two diodes and an L-C resonant circuit. The operation of the proposed system was analyzed using a theoretical approach with equivalent circuits and verified by computer simulations using a simulation program with integrated circuit emphasis and experimental work with a hardware prototype. The proposed system could be effectively applied to the power converter of a photovoltaic power system interconnected with an a.c. power system.  相似文献   
46.
    
This paper presents a timing controller embedded driver (TED) IC with 3.24‐Gbps embedded display port (eDP), which is implemented using a 45‐nm high‐voltage CMOS process for the chip‐on‐glass (COG) TFT‐LCD applications. The proposed TED‐IC employs the input offset calibration scheme, the zero‐adjustable equalizer, and the phase locked loop‐based bang‐bang clock and data recovery to enhance the maximum data rate. Also, the proposed TED‐IC provides efficient power management by supporting advanced link power management feature of eDP standard v1.4. Additionally, the smart charge sharing is proposed to reduce the dynamic power consumption of output buffers. Measured result demonstrates the maximum data rate of 3.24 Gbps from a 1.1 V supply voltage with a 7.9‐inch QXGA 60‐Hz COG‐LCD prototype panel and 44% power saving from the display system.  相似文献   
47.
    
Minoxidil is the most widely used treatment for hair growth, but has been associated with several side effects. In this study, we investigated the effects of heat-killed Enterococcus faecalis EF-2001 on hair loss prevention and regrowth using human dermal papilla cells and male C57BL/6 mice. To examine the effects of EF-2001, we used minoxidil as the positive control. In the in vitro experiments, EF-2001 treatment (75–500 μg/mL) led to the proliferation of human dermal papilla cells in a concentration-dependent manner. In the in vivo experiment, the topical application of 200 µL EF-2001 on the dorsal surface of C57BL/6 male mice led to hair growth. Changes in hair regrowth were examined by visual comparison and hematoxylin and eosin staining of skin sections. We also determined the expression levels of marker genes (Wnt) and growth factors (fibroblast growth factor, insulin growth factor 1, and vascular endothelial growth factor) in the skin tissues of the back of each mouse using a quantitative polymerase chain reaction. EF-2001 accelerated the progression of hair regrowth in mice and promoted hair-follicle conversion from telogen to anagen, likely by increasing the expression levels of growth factors and marker genes.  相似文献   
48.
    
Metalloendopeptidase ADAM-Like Decysin 1 (ADAMDEC1) is an anti-inflammatory peptidase that is almost exclusively expressed in the gastrointestinal (GI) tract. We have recently found abundant and selective expression of Adamdec1 in colonic mucosal PDGFRα+ cells. However, the cellular origin for this gene expression is controversial as it is also known to be expressed in intestinal macrophages. We found that Adamdec1 mRNAs were selectively expressed in colonic mucosal subepithelial PDGFRα+ cells. ADAMDEC1 protein was mainly released from PDGFRα+ cells and accumulated in the mucosal layer lamina propria space near the epithelial basement membrane. PDGFRα+ cells significantly overexpressed Adamdec1 mRNAs and protein in DSS-induced colitis mice. Adamdec1 was predominantly expressed in CD45− PDGFRα+ cells in DSS-induced colitis mice, with only minimal expression in CD45+ CD64+ macrophages. Additionally, overexpression of both ADAMDEC1 mRNA and protein was consistently observed in PDGFRα+ cells, but not in CD64+ macrophages found in human colonic mucosal tissue affected by Crohn’s disease. In summary, PDGFRα+ cells selectively express ADAMDEC1, which is localized to the colon mucosa layer. ADAMDEC1 expression significantly increases in DSS-induced colitis affected mice and Crohn’s disease affected human tissue, suggesting that this gene can serve as a diagnostic and/or therapeutic target for intestinal inflammation and Crohn’s disease.  相似文献   
49.
    
To increase the half-life of growth hormones, we proposed its long-lasting regulation through the ubiquitin-proteasome system (UPS). We identified lysine residues (K67, K141, and K166) that are involved in the ubiquitination of human growth hormone (hGH) using ubiquitination site prediction programs to validate the ubiquitination sites, and then substituted these lysine residues with arginine residues. We identified the most effective substituent (K141R) to prevent ubiquitination and named it AUT-hGH. hGH was expressed and purified in the form of hGH-His, and ubiquitination was first verified at sites containing K141 in the blood stream. Through the study, we propose that AUT-hGH with an increased half-life could be used as a long-lasting hGH in the blood stream.  相似文献   
50.
    
The adverse effects of radiation are proportional to the total dose and dose rate. We aimed to investigate the effects of radiation dose rate on different organs in mice. The mice were subjected to low dose rate (LDR, ~3.4 mGy/h) and high dose rate (HDR, ~51 Gy/h) radiation. LDR radiation caused severe tissue toxicity, as observed in the histological analysis of testis. It adversely influenced sperm production, including sperm count and motility, and induced greater sperm abnormalities. The expression of markers of early stage spermatogonial stem cells, such as Plzf, c-Kit, and Oct4, decreased significantly after LDR irradiation, compared to that following exposure of HDR radiation, in qPCR analysis. The compositional ratios of all stages of spermatogonia and meiotic cells, except round spermatid, were considerably reduced by LDR in FACS analysis. Therefore, LDR radiation caused more adverse testicular damage than that by HDR radiation, contrary to the response observed in other organs. Therefore, the dose rate of radiation may have differential effects, depending on the organ; it is necessary to evaluate the effect of radiation in terms of radiation dose, dose rate, organ type, and other conditions.  相似文献   
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