Human Endothelial Progenitor Cells Protect the Kidney against Ischemia-Reperfusion Injury via the NLRP3 Inflammasome in Mice

Ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) and progression to chronic kidney disease (CKD). However, no effective therapeutic intervention has been established for ischemic AKI. Endothelial progenitor cells (EPCs) have major roles in the maintenance of vascular integrity and the repair of endothelial damage; they also serve as therapeutic agents in various kidney diseases. Thus, we examined whether EPCs have a renoprotective effect in an IRI mouse model. Mice were assigned to sham, EPC, IRI-only, and EPC-treated IRI groups. EPCs originating from human peripheral blood were cultured. The EPCs were administered 5 min before reperfusion, and all mice were killed 72 h after IRI. Blood urea nitrogen, serum creatinine, and tissue injury were significantly increased in IRI mice; EPCs significantly improved the manifestations of IRI. Apoptotic cell death and oxidative stress were significantly reduced in EPC-treated IRI mice. Administration of EPCs decreased the expression levels of NLRP3, cleaved caspase-1, p-NF-κB, and p-p38. Furthermore, the expression levels of F4/80, ICAM-1, RORγt, and IL-17RA were significantly reduced in EPC-treated IRI mice. Finally, the levels of EMT-associated factors (TGF-β, α-SMA, Snail, and Twist) were significantly reduced in EPC-treated IRI mice. This study shows that inflammasome-mediated inflammation accompanied by immune modulation and fibrosis is a potential target of EPCs as a treatment for IRI-induced AKI and the prevention of progression to CKD.     

High‐Precision Temperature‐Controllable Metal‐Coated Polymeric Molds for Programmable,Hierarchical Patterning

Nanofabrication is an indispensable process in nanoscience and nanotechnology. Unconventional lithographic techniques are often used for fabrication as alternatives to photolithography because they are faster, more cost‐effective, and simpler to use. However, these techniques are limited in scalability and utility because of the collapse of preprinted structures during step‐and‐repeat processes. This study proposes a new class of temperature‐controllable polymeric molds that are coated with a metal such that any site‐specific patterning can be accomplished in a programmable manner using selective contact‐dewetting lithography. The lithography allows sub‐100 nm patterning, step‐and‐repeat processing, and hierarchical structure fabrication. The programmable feature of the lithography can be utilized for the structural coloring and shaping of objects. Large‐area programmable patterning, semiconductor device manufacturing, and the fabrication of iridescent security devices would benefit from the unique features of the proposed strategy.     

Orientation-Dependent Developments in Misorientation and Residual Stress in Rolled Aluminum: The Defining Role of Dislocation Interactions

Orientation-dependent developments in misorientation and residual stress, in rolled aluminum, were quantified experimentally and simulated numerically. The latter involved analysis using a crystal plasticity finite element model, accounting for anisotropies in slip system hardening but neglecting near-neighbor interactions, and discrete dislocation dynamics of the single crystals. Both were successful in capturing the experimental patterns of orientation dependence. Numerical simulations, without slip transfer across the neighboring grains, thus established the defining role of dislocation interactions in establishing orientation-sensitive microstructural evolution.     

Efficacy of Trust-Building Tactics in Construction Mediation

Distrust hinders disputing parties and mediators from achieving mediation success. Mediators therefore often use different trust-building tactics to generate some degree of trust in themselves and in the mediation process. This paper reports a study that identified the trust-building tactics used by construction mediators and examined the efficacy of these tactics with respect to their outcomes. Three study stages were designed. With reference to the mediation model of Sloan (1998), trust-building tactics and outcomes were first identified in Stage I. Next, the data were collected from accredited mediators with a questionnaire survey in Stage II. The collected data were then validated via reliability assessments in Stage III. With the use of multiple regression analyses, the efficacy of the trust-building tactics was examined by relating these tactics to their outcomes. The findings of this study suggest that the trust-building tactics used in Step 4 (i.e., explore interests) of Sloan’s (1998) mediation model are influential in developing trust among disputing parties and that they can also act as a time-saving tool in the mediation process. Furthermore, it was found that mediators can earn trust by adopting the trust-building tactics used in Step 3 (i.e., issues and trust) of Sloan’s (1998) model. These tactics can also serve to improve the relationships between the disputing parties. The results show that the trust-building tactics used in the final step (i.e., solutions) of Sloan’s (1998) model seem to have low efficacy in developing trust among disputing parties.     

Mechanism of droplet generation in silver thin films for organic light-emitting diode displays

Thin silver film is widely used as the cathode in organic light-emitting diode displays and it is generally fabricated using the thermal evaporation method. But during the evaporation process, there is an inevitable outgassing problem and this creates high viscosity bubbles in melted silver. When the bubbles break, the high energy released scatters silver droplets which damage the silver surface. In this study, we were able to decrease the number of droplets from 6,171 to 278 with a degassing process of 400 °C for 6 h before proceeding with a thermal evaporation process.     

Coupling-loss reduction of a vertically coupled microring resonator filter by spot-size-matched busline waveguides

To improve the input-output coupling loss of a vertically coupled microring resonator filter, we fabricated microring resonators on an antiresonant reflecting optical waveguide (ARROW) with a large spot size and on the rectangular busline waveguide with a spot-size transformer. The spot size and the tapered structure were optimally designed from the viewpoint of spot-size matching to single-mode fibers and the reduction of radiation loss. Clear dropping responses were demonstrated for the ARROW-based microring resonator filters, and the coupling loss was successfully reduced by 22 dB.     

AC losses in multilayer superconducting tapes

ac losses have been investigated experimentally as well as theoretically in tapes having on the surface several normal conducting and/or superconducting layers. The superconducting layers under investigation have been Nb₃Sn on a niobium substrate and Nb₃Ge on a stainless steel substrate. It has been proved that the layered structure of the tapes is well reflected by the stepwise character of the ac losses dependence on the amplitude of the surface magnetic field. The magnetic flux passing through a surperconducting layer or surface barrier into the inside of the tape enhances the losses in the passed barrier or layer.     

An asymptotically exact LMI solution to the robust discretisation of LTI systems with polytopic uncertainties and its application to sampled-data control

In this paper, the problem of robust discretisation of linear time-invariant (LTI) systems with polytopic uncertainties is introduced. More specifically, the main objective is to provide a systematic way to find an approximate discrete-time (DT) model of a continuous-time (CT) plant with uncertainties in polytopic domain. The system matrices of polytopic DT model to be found are expressed as parameter-dependent matrices which are homogeneous polynomials of arbitrary degree with respect to the uncertain variables in the simplex, and is obtained in such a way that the norm between the system matrices and the truncated power series of the exact DT model is minimised while preserving the polytopic structure of the original CT plant. The solution procedures proposed are presented in terms of single-parameter minimisation problems subject to linear matrix inequality (LMI) constraints which are numerically tractable via LMI solvers. Finally, examples are given to show the validity and effectiveness of the proposed techniques.