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41.
Remnants of chylomicron and very low density lipoprotein impair endothelium-dependent vasorelaxation
H Doi K Kugiyama M Ohgushi S Sugiyama T Matsumura Y Ohta T Nakano K Nakajima H Yasue 《Canadian Metallurgical Quarterly》1998,137(2):341-349
Given the multiple impairments in host defense that occur during HIV infection, patients with AIDS are at risk for a variety of pleural infections and neoplasms. Of infectious causes, bacterial parapneumonic effusions and empyemas and tuberculous pleurisy occur more frequently than effusions caused by P. carinii. In each case, therapy is directed at eradication of the causative organisms. In the setting of systemic Kaposi's sarcoma, pleural involvement is common, although diagnosis is difficult and therapeutic options are limited. Pleural effusions caused by non-Hodgkin's lymphoma often occur in the setting of pulmonary parenchymal disease and can be diagnosed cytologically. The recently described entity of primary effusion lymphoma occurs in the absence of solid-organ involvement. The development of a spontaneous pneumothorax in a HIV-infected individual should prompt a search for P. carinii infection. Although these pneumothoraces often recur and are difficult to manage, recent series suggest that surgical approaches to bronchopleural fistulas are reasonable in selected patients. 相似文献
42.
H Matsuno E Sugiyama A Muraguchi T Nezuka T Kubo K Matsuura H Tsuji 《Canadian Metallurgical Quarterly》1998,20(6):295-304
SA96 (generic name, bucillamine) is a disease-modifying anti-rheumatoid arthritis (RA) drug with immunological effects. This compounds has two sulfhydryl groups in its molecule, and the differences and similarities between this drug and D-penicillamine, which is also a sulfhydryl group-containing anti-rheumatic drug, have frequently been discussed. To clarify the pharmacological differences between these two drugs, we examined the concentrations of the compounds and its metabolites in serum and synovial fluid, paying special attention to the metabolites of SA96 produced in vivo. SA96 was metabolized in a very short time to SA981 which is a disulfide compound formed by intramolecular binding of two sulfhydryl groups, and transferred to synovial fluid. In addition SA981 had significant suppressive effects on IL-6 and IL-8 production by synovial cells in vitro. These results demonstrate that SA96, which has two sulfhydryl groups, exhibits anti-rheumatic effects via a pharmacological action clearly different from that of D-penicillamine. 相似文献
43.
PURPOSE: To investigate the effects of radiation on anorectal function in patients with carcinoma of the uterine cervix. METHODS AND MATERIALS: Anorectal manometry was carried out on 24 patients (complication group) with late radiation proctitis. All of the manometric data from these patients were compared with those from 24 age-matched female volunteers (control group), in whom radiation treatment had not yet been performed. RESULTS: Regardless of the severity of proctitis symptoms, 25% of patients demonstrated all their manometric data within the normal range, but 75% of patients exhibited one or more abnormal manometric parameters for sensory or motor functions. Six patients (25%) had an isolated sensory dysfunction, eight patients (33.3%) had an isolated motor dysfunction, and four patients (16.7%) had combined disturbances of both sensory and motor functions. The maximum tolerable volume, the minimal threshold volume, and the urgent volume in the complication group were significantly reduced compared with those in the control group. The mean squeeze pressure in the complication group was significantly reduced, whereas the mean resting pressure and anal sphincter length were unchanged. CONCLUSIONS: Physiologic changes of the anorectum in patients with late radiation proctitis seem to be caused by a variety of sensory and/or motor dysfunctions in which many different mechanisms are working together. The reduced rectal reservoir capacity and impaired sensory functions were crucial factors for functional disorder in such patients. In addition, radiation damage to the external anal sphincter muscle was considered to be an important cause of motor dysfunction. 相似文献
44.
Y Sawada N Itoh Y Sugiyama T Iga M Hanano 《Computer methods and programs in biomedicine》1985,20(1):51-61
A model is developed to estimate the renal tubular secretory parameters by the multiple indicator dilution (MID) technique. The model allows the calculation of influx (from plasma space to tubular cell), efflux (from tubular cell to plasma space) and sequestration (from tubular cell to luminal side) rate constants. A program using the MID-statistical analysis with least squares fitting (SALS) system for the estimation of these parameters is presented. A trapezoid rule and a non-linear least squares regression were used to carry out definite integrals of cubic spline function and least squares fitting, respectively. The system presented seems to be useful for the precise and rapid estimation of the tubular secretory rate constants. 相似文献
45.
C Kawanishi Y Shimoda J Fujimaki H Onishi K Suzuki T Hanihara N Sugiyama K Kosaka 《Canadian Metallurgical Quarterly》1998,160(1):102-104
Traumatic injuries of arteries lead to acute bleeding or ischemia. In the hand, which is perfused by two arteries, this symptom could be missed. The hypothenar hammer syndrome is a traumatic occlusion of the distal arteria ulnaris. Dependent on the mechanism of the trauma the clinical symptoms may appear late. A specific angiographic or duplex sonographic diagnostic investigation is necessary to show the arterial occlusion. There is no proven therapeutic procedure. Exact diagnosis of the occlusion as an effect of the trauma is important for the patient and is the basis of any therapeutic intervention. 相似文献
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New inorganic-organic coatings for nonoriented electrical sheets have been developed. Smooth and dull sheets having surface roughnesses of 0.18 μm. H root mean square (rms) and 0.75 μm. H rms, respectively, were coated with different weights of a bichromate-emulsion resin solution. Another sheet having a surface roughness of 0.18 μm. H rms was treated with a bichromate-emulsion resin solution containing a dispersed polyethylene resin powder to provide surface roughness. Results indicated that this third sheet exhibits a higher lamination factor and surface resistivity than the coated sheet whose surface roughness is provided by the dullness of the sheet itself. Moreover, it has a lower core loss and requires less ac exciting current when used in welded motor cores at given thicknesses. When weldability is not a factor, then the smooth sheet having a surface roughness of 0.18 μm. H rms and treated with the inorganic-organic coating is the most suitable: it has the highest lamination factor, the least amount of core loss, and requires the least amount of ac exciting current. 相似文献
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