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This paper reports on an ergonomic study carried out during the design of a cutting machine-tool for the composite material in carbody parts casting. During this design process, the users’ needs were inferred by the designers on the basis of their own mental representations of the use of the new device. These representations of the users’ needs, correct or false, play a decisive role in the choice of a solution. The aim of the study is to identify their particularity. Analyzing the design meetings, we have highlighted that users are considered either as subsystems or basic design principles or elements of an imagined scenario. We have shown that these representations are linked to the types of meetings held during the design process. Accordingly, a diversification of the types of meetings should be promoted by the project leader, so that designers extend their points of view of the operators. 相似文献
23.
The general label-placement problem consists in labeling a set of features (points, lines, regions) given a set of candidates
(rectangles, circles, ellipses, irregularly shaped labels) for each feature. The problem arises when annotating classical
cartographical maps, diagrams, or graph drawings. The size of a labeling is the number of features that receive pairwise nonintersecting
candidates. Finding an optimal solution, i.e., a labeling of maximum size, is NP-hard.
We present an approach to attack the problem in its full generality. The key idea is to separate the geometric part from
the combinatorial part of the problem. The latter is captured by the conflict graph of the candidates. We present a set of
rules that simplify the conflict graph without reducing the size of an optimal solution. Combining the application of these
rules with a simple heuristic yields near-optimal solutions.
We study competing algorithms and do a thorough empirical comparison on point-labeling data. The new algorithm we suggest
is fast, simple, and effective.
Received December 21, 1998; revised October 13, 1999. 相似文献
24.
A robust and accurate polarization phase-based technique for material classification is presented. The novelty of this technique is three-fold in (i) its theoretical development, (ii) application, and, (iii) experimental implementation. The concept of phase of polarization of a light wave is introduced to computer vision for discrimination between materials according to their intrinsic electrical conductivity, such as distinguishing conducting metals, and poorly conducting dielectrics. Previous work has used intensity, color and polarization component ratios. This new method is based on the physical principle that metals retard orthogonal components of light upon reflection while dielectrics do not. This method has significant complementary advantages with respect to existing techniques, is computationally efficient, and can be easily implemented with existing imaging technology. Experiments for real circuit board inspection, nonconductive and conductive glass, and, outdoor object recognition have been performed to demonstrate its accuracy and potential capabilities. 相似文献
25.
Valeria Gaspari Camilla Ceccarani Marco Severgnini Gionathan Orioni Tania Camboni Luca Laghi Sara Morselli Claudio Foschi Antonella Marangoni Clarissa Consolandi Bianca Maria Piraccini 《International journal of molecular sciences》2022,23(10)
Background: Chlamydia trachomatis (CT) is the agent of the most common bacterial sexually transmitted infection worldwide. Until now, little information is available about the microbial composition of urine samples during CT urethritis. Therefore, in this study, we characterized the microbiome and metabolome profiles of first-void urines in a cohort of women with CT urethral infection attending an STI clinic. Methods: Based on CT positivity by nucleic acid amplification techniques on urine samples, the enrolled women were divided into two groups, i.e., “CT-negative” (n = 21) and “CT-positive” (n = 11). Urine samples were employed for (i) the microbiome profile analysis by means of 16s rRNA gene sequencing and (ii) the metabolome analysis by 1H-NMR. Results: Irrespective of CT infection, the microbiome of first-void urines was mainly dominated by Lactobacillus, L. iners and L. crispatus being the most represented species. CT-positive samples were characterized by reduced microbial biodiversity compared to the controls. Moreover, a significant reduction of the Mycoplasmataceae family—in particular, of the Ureaplasma parvum species—was observed during CT infection. The Chlamydia genus was positively correlated with urine hippurate and lactulose. Conclusions: These data can help elucidate the pathogenesis of chlamydial urogenital infections, as well as to set up innovative diagnostic and therapeutic approaches. 相似文献
26.
Albena Momchilova Roumen Pankov Alexander Alexandrov Tania Markovska Stefan Pankov Plamen Krastev Galya Staneva Evgenia Vassileva Nikolai Krastev Adriana Pinkas 《International journal of molecular sciences》2022,23(14)
Multiple sclerosis (MS) is an autoimmune, inflammatory, degenerative disease of the central nervous system. Changes in lipid metabolism have been suggested to play important roles in MS pathophysiology and progression. In this work we analyzed the lipid composition and sphingolipid-catabolizing enzymes in erythrocytes and plasma from MS patients and healthy controls. We observed reduction of sphingomyelin (SM) and elevation of its products—ceramide (CER) and shingosine (SPH). These changes were supported by the detected up-regulation of the activity of acid sphingomyelinase (ASM) in MS plasma and alkaline ceramidase (ALCER) in erythrocytes from MS patients. In addition, Western blot analysis showed elevated expression of ASM, but not of ALCER. We also compared the ratios between saturated (SAT), unsaturated (UNSAT) and polyunsaturated fatty acids and suggest, based on the significant differences observed for this ratio, that the UNSAT/SAT values could serve as a marker distinguishing erythrocytes and plasma of MS from controls. In conclusion, the application of lipid analysis in the medical practice would contribute to definition of more precise diagnosis, analysis of disease progression, and evaluation of therapeutic strategies. Based on the molecular changes of blood lipids in neurodegenerative pathologies, including MS, clinical lipidomic analytical approaches could become a promising contemporary tool for personalized medicine. 相似文献
27.
Ohne Zusammenfassung 相似文献
28.
Ohne Zusammenfassung 相似文献
29.
Research on vehicular ad hoc networks has focused mainly on efficient routing protocol design under conditions where there are relatively large numbers of closely spaced vehicles. These routing protocols are designed principally for urban areas with high node density and fully connected networks and are not suitable for packet delivery in a sparse, partially connected VANET. In this article, we examine the challenges of VANETs in sparse network conditions, review alternatives including epidemic routing, and propose a border node-based routing protocol for partially connected VANETs. The BBR protocol can tolerate network partition due to low node density and high node mobility. The performance of epidemic routing and BBR are evaluated with a geographic and traffic information- based mobility model that captures typical highway conditions. The simulation results show that under rural network conditions, a limited flooding protocol such as BBR performs well and offers the advantage of not relying on a location service required by other protocols proposed for VANETs. 相似文献
30.
Melinda Varga Paul Wolff Klaus-Juergen Wolter 《Journal of materials science. Materials in medicine》2017,28(2):30
Neural interfaces hold great promise for research and treatment of a wide variety of neurological diseases. Medical electrodes are designed to interface with the nervous system and provide control signals for neural prostheses. We fabricated previously a hook-up neural electrode. Here we investigate the in vitro cytotoxicity of three commercial carbon pastes used for printing the conductor tracks of this electrode. At first, the carbon pastes were characterized with respect to their microstructure and chemical composition. SEM images showed a grainy texture that is associated to the carbon/graphite microparticles dispersed by the polymeric binder. All the three pastes contained in major proportions carbon and in different proportions other elements. The surface roughness analysis evidenced differences in the smoothness of the carbon paste surfaces. Sterilization procedures did not alter the microstructure or surface morphology of the pastes. Finally, cell viability based on -(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test and fluorescence staining experiments proved non-cytotoxicity and suitability of the studied carbon pastes as electrode material for measuring neural activity during surgeries (up to a certain time period). 相似文献