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91.
BACKGROUND AND PURPOSE: A rapid but transient expression of c-fos after cerebral ischemia has been extensively documented. However, the mechanism of this induction and whether induction of c-fos is neuroprotective or detrimental to the brain after ischemia is presently not clear. Fasting before transient cerebral ischemia has been shown to reduce delayed neuronal necrosis and infarct volume. The purpose of the present study was to examine the effect of preischemic fasting for 24 hours on the expression of c-fos after transient focal cerebral ischemia. METHODS: Focal cerebral ischemia was induced by temporary occlusion of the right middle cerebral artery and both common carotid arteries for 60 minutes. Male Long-Evans rats weighting 250 to 300 g were randomly divided into two groups: fed (control group) and food deprived for 24 hours (fasted group) before ischemic surgery. Infarct volumes were measured on the basis of triphenyltetrazolium chloride-delineated infarct areas, and plasma glucose levels were determined by the glucose oxidase method. Temporal and spatial expression of c-fos was assessed by Northern blot analysis, in situ hybridization, and immunohistochemistry. RESULTS: Fasting for 24 hours before 60 minutes of ischemia resulted in a 26.6% decrease in preischemic plasma glucose levels and a 74.5% reduction in infarct volumes in the fasted group compared with the control group. A rapid but transient induction of c-fos mRNA was observed in the ischemic cortex in control animals after 60 minutes of ischemia. Fasting not only prolonged but also enhanced the intensity of c-fos expression in the ischemic cortex. Regional c-fos expression was also different between these two groups. CONCLUSIONS: The results support the contention that c-fos expression may be compatible with its purported neuroprotective role in selected experimental paradigms. The signaling mechanisms underlying the effect of fasting and subsequent lowering of plasma glucose levels on postischemic c-fos expression remain to be explored. 相似文献
92.
采用声波测井、地震CT等综合物探方法 ,对正义峡水库坝址基础岩体固结灌浆质量进行检测 ,基本查明了坝基岩体固结灌浆后的质量状况 ,取得了良好的应用效果 相似文献
93.
本文通过对某液压挖掘机工作装置实验样本长度的研究,详细讨论了样本长度的确定方法,重点分析了趋势曲线拟合法,提出了样本长度精度区间分析的方法,并在处理大量实验数据的基础上,从载荷分布及寿命估算的角度做了实际的验证.编制了应用程序,使样本长度确定至寿命估算整个过程程序化. 相似文献
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随着国际交流的日益加深,人们讨论的重点多是跨文化的接触以及频繁接触中的文化认同问题。西方许多领域的学者已把“西方中的东方”(the East in the west)纳入他们的研究领域中。因此,我们随处可以读到西方人有关中国文化的评论。服饰文化研究者也应学会认识异域文化(the West in the East),本文通过对民族服饰变异实例的研究,探索促成民族服饰变异的文化因素和历史根源,从而揭示文化变迁与服饰变异的关系。 相似文献
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��Adopting the surface analysis and surplus value treatment,the sub-crests covered by the main structure have been circled on the structure map of the top of Yangxin series in Wolonghe gas field,As compared with drilling,the result is very good,The drilling succes ratio is 53.8% on the positive surplus value area,and 66.6% on the sub crest. Popularizing this method will lead to a visible raise of economic profit. 相似文献
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Kazutaka Chibana Chaedong Kang Masashi Okada Koji Matsumoto Tetsuo Kawagoe 《International Journal of Refrigeration》2002,25(2):83
Water-silicone oil emulsion with an additive, (C2H5O)3SiC3H6NH2, was examined as a heat storage material. A spiral tube used as a heat exchanger was immersed in a low temperature bath and the emulsion was circulated in the tube to make ice continuously. Ice was separated from the ice–liquid suspension in an outlet tank. The amount of formed ice, the temperatures of the inlet and the outlet of the heat exchanger, and the temperatures in the tube wall were measured and the overall heat transfer coefficient and the heat flux through the tube were calculated. Experiments were carried out, varying the flow rate, the temperature of cooling brine, and the thickness of tube wall. The condition under which slurry ice was formed continuously without adhesion of ice to the cooling wall was clarified. Though decrease in the thermal resistance of the tube increased the rate of ice formation or raised the brine temperature, it narrowed the range of the flow rate and of the brine temperature in which slurry ice was formed continuously. 相似文献