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21.
Dietary stearic acid and risk of cardiovascular disease: Intake,sources, digestion,and absorption 总被引:1,自引:2,他引:1
Individual FA have diverse biological effects, some of which affect the risk of cardiovascular disease (CVD). In the context
of food-based dietary guidance designed to reduce CVD risk, fat and FA recommendations focus on reducing saturated FA (SFA)
and trans FA (TFA), and ensuring an adequate intake of unsaturated FA. Because stearic acid shares many physical properties with the
other long-chain SFA but has different physiological effects, it is being evaluated as a substitute for TFA in food manufacturing.
For stearic acid to become the primary replacement for TFA, it is essential that its physical properties and biological effects
be well understood. 相似文献
22.
Terry Carolyn J.; Blake Colin C. F. 《Protein engineering, design & selection : PEDS》1992,5(6):505-510
The structure of cleaved thyroxine-binding globulin (TBG) hasbeen modelled on the crystal structure of cleaved 1-antitrypsin(a member of the serine proteinase inhibitor, serpin, superfamily)based on the high sequence homology exhibited by the two proteins.Particular attention was paid to the identification and modelledcharacteristics of the thyroxine binding site. The primary aimof the study was to compare the site qualitatively with thecrystallographically determined binding site of transthyretin,the other major transporter of thyroxine, in an attempt to explainthe higher binding affinity of the site compared with the knownthyrox ine binding site in transthyretin (1010 versus 108 M1).The proposed binding site shares some similar characteristicswith the transthyretin binding site but also includes a clusterof aromatic residues which are entirely absent in transthyretin.It is proposed that this might account for the substantial differencein binding affinities. 相似文献
23.
Meadowfoam fatty acids, when treated with mineral acid catalysts in the presence of polar nonparticipating solvents, undergo
a facile ring closure to form δ-lactones. Perchloric and sulfuric acids catalyze the cyclization at concentrations of 0.6–13
mole equivalents, both neat and in the presence of solvent. Under constant acid concentrations, methylene chloride was found
to increase the rate of reaction, the regioselectivity for the formation of δ-lactone, and the overall yield. In the absence
of solvent, increased acid concentration improved the yield of lactone but reduced regioselectivity for the δ-isomer. Solvent
polarity plays a significant role in the regioselectivity of the cyclization for δ-lactone, with solvents of higher dielectric
strength providing larger δ/γ ratios (38:1) and higher yields up to 92%. 相似文献
24.
Keiichiro Oh-ishi John Boydon Terry R. McNelley 《Journal of Materials Engineering and Performance》2004,13(6):710-719
The importance of grain size refinement in enabling superplasticity is reviewed, and the current understanding of grain boundary
characteristics is summarized. The application of orientation-imaging microscopy (OIM) methods to the processing response
and the deformation and failure modes in superplastic aluminum alloys are illustrated through microtexture analysis and determination
of grain boundary characteristics in selected commercial materials. Continuous and discontinuous recrystallization reactions
exhibit distinct microtextures and grain boundary characteristics. The application of OIM and microtexture analysis to the
evaluation of both deformation and failure mechanisms during superplastic forming is illustrated.
This paper was presented at the International Symposium on Superplasticity and Superplastic Forming, sponsored by the Manufacturing
Critical Sector at the ASM International AeroMat 2004 Conference and Exposition, June 8–9, 2004, in Seattle, WA. The symposium
was organized by Daniel G. Sanders, The Boeing Company. 相似文献
25.
Terry C. Lowe Ruslan Z. Valiev 《JOM Journal of the Minerals, Metals and Materials Society》2004,56(10):64-68
Severe plastic deformation (SPD) has emerged as a promising method to produce ultrafine-grained materials with attractive
properties. Today, SPD techniques are rapidly developing and are on the verge of moving from lab-scale research into commercial
production. This paper discusses new trends in the development of SPD techniques suchas high-pressure torsion and equal-channel
angle pressing, as well as new alternative techniques for introducing SPD. The paper also contains a comparative analysis
of SPD techniques in terms of their relative capabilities for grain refinement, enhancement of properties, and potential to
economically produce ultrafine-grained metals and alloys.
For more information, contact Terry C. Lowe, Science and Technology Base Programs, Los Alamos National Laboratory, Los Alamos,
NM 87545; (505) 667-7824; fax (505) 665-3199; e-mail tlowe@lanl.gov. 相似文献
26.
This paper outlines the major motivating factors concerning a novel collaborative project between Edinburgh College of Art and Edinburgh Virtual Environment Centre. The Tacitus project will investigate the use of multi-modal virtual environments, specifically, the haptic (touch) modality, with regards to the creative processes employed by designers working within the field of applied arts. The salient areas of research are described, and the methods by which information regarding these areas will be obtained are considered. Initial investigations have revealed a strong need to mimic the traditional applied artists' workspaces, with co-location of visual and haptic cues a priority. 相似文献
27.
Testing Forecast Accuracy of Foreign Exchange Rates: Predictions from Feed Forward and Various Recurrent Neural Network Architectures 总被引:3,自引:1,他引:2
In this research, we work with data of futures contracts on foreign exchange rates for British pound (BP), Canadian dollar
(CD), and Japanese yen (JY) that are traded at the Chicago Mercantile Exchange (CME) against US dollars. We model relationships
between exchange rates in these currencies using linear models, feed forward artificial neural networks (ANN), and three versions
of recurrent neural networks (RNN1, RNN2 and RNN3) for predicting exchange rates in these currencies against the US dollar.
Our results on forecast evaluations based on AGS test the tests of forecast equivalence between any two competing models among
the entire models employed for each of the series show that ANN and the three versions of RNN models offer superior forecasts
for predicting BP, CD and JY exchange rates although the forecast evaluations based on MGN test are in sharp contrast. On
the other hand forecast based on SIGN test shows that ANN and all the versions of RNN models offer superior forecasts for
BP and CD in exception of JY exchange rates. The results for forecast evaluation for all the models for each of the series
based on summary measures of forecast evaluations show that RNN3 model appears to offer the most accurate predictions of BP
and RNN1 for JP exchange rates. However, none of the RNN models appear to be statistically superior to the benchmark (i.e.,
linear model) for predicting CD exchange rates.
相似文献
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When individuals encounter new information (data), that information is incorporated with their existing beliefs (prior) to form a new belief (posterior) in a process referred to as belief updating. While most studies on rational belief updating in visual data analysis elicit beliefs immediately after data is shown, we posit that there may be critical movement in an individual's beliefs when elicited immediately after data is shown v. after a temporal delay (e.g., due to forgetfulness or weak incorporation of the data). Our paper investigates the hypothesis that posterior beliefs elicited after a time interval will “decay” back towards the prior beliefs compared to the posterior beliefs elicited immediately after new data is presented. In this study, we recruit 101 participants to complete three tasks where beliefs are elicited immediately after seeing new data and again after a brief distractor task. We conduct (1) a quantitative analysis of the results to understand if there are any systematic differences in beliefs elicited immediately after seeing new data or after a distractor task and (2) a qualitative analysis of participants' reflections on the reasons for their belief update. While we find no statistically significant global trends across the participants beliefs elicited immediately v. after the delay, the qualitative analysis provides rich insight into the reasons for an individual's belief movement across 9 prototypical scenarios, which includes (i) decay of beliefs as a result of either forgetting the information shown or strongly held prior beliefs, (ii) strengthening of confidence in updated beliefs by positively integrating the new data and (iii) maintaining a consistently updated belief over time, among others. These results can guide subsequent experiments to disambiguate when and by what mechanism new data is truly incorporated into one's belief system. 相似文献