Blast-resistant structural concrete and steel connections

A series of numerical studies were conducted on the behavior of structural concrete and structural steel connection subjected to blast loads. These studies gradually enhanced the understanding of the role that structural details play in affecting the behavior. Observations from those studies highlighted possible safety concerns with current blast design procedures. Conclusions and recommendations are provided for correcting the observed problems.     

Kurze Mitteilungen aus der Praxis

Ohne Zusammenfassung     

MS Binding Assays for D1 and D5 Dopamine Receptors

MS Binding Assays are a label‐free alternative to radioligand binding assays. They provide basically the same capabilities as the latter, but an unlabeled reporter ligand is used instead of a radioligand. The study presented herein describes the development of MS Binding Assays that address D₁ and D₅ dopamine receptors. A highly sensitive, rapid and robust LC–ESI‐MS/MS quantification method for the selective D₁ dopamine receptor antagonist SCH23390 ((5R)‐8‐chloro‐3‐methyl‐5‐phenyl‐1,2,4,5‐tetrahydro‐3‐benzazepin‐7‐ol) was established and validated, using its 8‐bromo analogue SKF83566 as an internal standard. This quantification method proved to be suitable for the characterization of SCH23390 binding to human D₁ and D₅ receptors. Following the concept of MS Binding Assays, saturation experiments for D₁ and D₅ receptors were performed, as well as competition experiments for D₁ receptors. The results obtained are in good agreement with results from radioligand binding assays and therefore indicate that the established MS Binding Assays addressing D₁ and D₅ receptors are well‐suited substitutes for radioligand binding assays, the technique that has so far dominated affinity determinations toward these targets.     

Probing first-order spatial coherence of a Bose-Einstein condensate

Abstract

We probe the spatial coherence properties of a magnetically trapped Bose gas. Two matter wave beams are extracted from two spatially separated regions of the trap and overlap outside the trapping region. The visibility of the resulting interference pattern measures the phase coherence between the regions of extraction. By varying the spatial separation between the two regions the first-order spatial correlation function of the trapped Bose gas can be measured. The location of the minima of the interference pattern is reproducible, which experimentally confirms that the trapped Bose-Einstein condensate is not fragmented into individual condensates.     

Seeing the Objects Behind the Dots: Recognition in Videos from a Moving Camera

Category-level object recognition, segmentation, and tracking in videos becomes highly challenging when applied to sequences from a hand-held camera that features extensive motion and zooming. An additional challenge is then to develop a fully automatic video analysis system that works without manual initialization of a tracker or other human intervention, both during training and during recognition, despite background clutter and other distracting objects. Moreover, our working hypothesis states that category-level recognition is possible based only on an erratic, flickering pattern of interest point locations without extracting additional features. Compositions of these points are then tracked individually by estimating a parametric motion model. Groups of compositions segment a video frame into the various objects that are present and into background clutter. Objects can then be recognized and tracked based on the motion of their compositions and on the shape they form. Finally, the combination of this flow-based representation with an appearance-based one is investigated. Besides evaluating the approach on a challenging video categorization database with significant camera motion and clutter, we also demonstrate that it generalizes to action recognition in a natural way. Electronic Supplementary Material  The online version of this article () contains supplementary material, which is available to authorized users. This work was supported in part by the Swiss national science foundation under contract no. 200021-107636.