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961.
Freddy A. Bernal Dr. Marcel Kaiser Prof. Dr. Bernhard Wünsch Prof. Dr. Thomas J. Schmidt 《ChemMedChem》2020,15(1):68-78
Protozoal infections are still a global health problem, threatening the lives of millions of people around the world, mainly in impoverished tropical and sub-tropical regions. Thus, in view of the lack of efficient therapies and increasing resistances against existing drugs, this study describes the antiprotozoal potential of synthetic cinnamate ester analogues and their structure-activity relationships. In general, Leishmania donovani and Trypanosoma brucei were quite susceptible to the compounds in a structure-dependent manner. Detailed analysis revealed a key role of the substitution pattern on the aromatic ring and a marked effect of the side chain on the activity against these two parasites. The high antileishmanial potency and remarkable selectivity of the nitro-aromatic derivatives suggested them as promising candidates for further studies. On the other hand, the high in vitro potency of catechol-type compounds against T. brucei could not be extrapolated to an in vivo mouse model. 相似文献
962.
Muoz-Lpez Cesar Nadem Daz-Silvestre Sergio Telles-Padilla J. Guadalupe Rivera-Vallejo Claudia St Thomas Claude Jimnez-Regalado Enrique 《Polymer Bulletin》2020,77(5):2539-2555
Polymer Bulletin - Preparation of associating multiblock copolymer electrolytes mediated by radical addition–fragmentation chain transfer (RAFT) technique has been evaluated and reported in... 相似文献
963.
Marc W. Bird Robert P. Aune Alfred F. Thomas Paul F. Becher Kenneth W. White 《Journal of the European Ceramic Society》2012,32(12):3453-3462
Hot pressed ZrB2–20 vol.% SiC ultra-high temperature ceramic composites have been prepared for strength and fracture investigations. Two composites fabricated under differing hot pressing temperatures with (ZSB) and without (ZS) B4C sintering aids were selected for room temperature modulus of rupture (MOR) strength and single-edge-notch bend (SENB) fracture toughness experiments. Structure property relationships were examined for both composites. MOR and stiffness temperature dependence was also investigated up to 1500 °C. Long crack propagation studies were conducted up to 1400 °C using the double cantilevered beam geometry with half-chevron-notch initiation zones. Residual Boron-rich carbide maximum particle sizes were found to be strength limiting in ZSB billets while SiC controlled strength in ZS billets. Flexure strength decreased linearly with temperature from 1000 to 1500 °C with no visible plastic deformation prior to fracture. Similar stiffness decreases were observed with a transition temperature range of 1100–1200 °C. Long crack studies produced R-curves that show no significant toughening behavior at room temperature with some modest rising R-curve behavior appearing at higher temperatures. These studies also show the plateau toughness increases with temperature up to 1200 °C. This is supported by an observed transition from primarily transgranular fracture at room temperature to primarily intergranular fracture at high temperatures. Wake zone toughening is evident up to 1000 °C with KR rise from 0.1 to 0.5 MPa√m. Beyond 1000 °C fracture mechanism transitions to include creep zone development ahead of crack tip with wake zone toughening vanishing. 相似文献
964.
Claus H. Rüscher Holger Fritze Günter Borchardt Thomas Witke Bernd Schultrich 《Journal of the American Ceramic Society》1997,80(12):3225-3228
Mullite (3Al2 O3 ·2SiO2 ) coatings on SiC substrates and SiC precoated carbon/carbon composite (C/C-Si-SiC) substrates were produced by pulsed laser deposition (PLD) using pressed mullite powder targets. The layers can be characterized efficiently by IR reflection spectroscopy in the spectral range between 650 and 5000 cm−1 . The deposited coatings turn into mullite upon oxidation in air at temperatures between 1400° and 1600°C. Fabry-Perot interferences indicate a high quality and homogeneity of the mullite coating/SiC substrate interface. Amorphous SiO2 gradually forms during prolonged heating or at higher temperatures. 相似文献
965.
Thomas R 《Chembiochem : a European journal of chemical biology》2001,2(9):612-627
Polyketides are one of the largest and most structurally diverse classes of naturally occurring compounds, ranging from simple aromatic metabolites to complex macrocyclic lactones. Fungi and filamentous bacteria, particularly the actinomycetes, are major sources of polycyclic aromatic structures, which include many clinically important antibiotics and other useful metabolites. These fused-ring polyketides are formed by the action of polyketide synthases (PKSs), which catalyse the assembly, folding and cross-linking of poly-beta-ketoacyl intermediates. In view of the taxonomic gulf between the eukaryotic fungi and prokaryotic bacteria, it is not surprising that they are rarely found to produce structurally identical fused-ring metabolites. A review of [(13)C(2)]acetate incorporation data has revealed consistent differences in the reported cyclisation patterns, which require regiospecifically distinct cross-linking of otherwise identical linear polyketide precursors. This observation provides the basis for a structural and biosynthetic classification of microbial fused-ring polyketides, which has a number of useful ramifications. 相似文献
966.
Jan Schauer Wolfgang Albrecht Thomas Weigel Vlastimil Kdela Zbynek Pientka 《应用聚合物科学杂志》2001,81(1):134-142
Membranes were prepared from solutions containing Udel‐type polysulfone (PSf) and sulfonated poly(2,6‐dimethyl‐1,4‐phenylene oxide) (SPPO). Polymer solutions in 1‐methyl‐2‐pyrrolidone were cast on a nonwoven textile and precipitated in a water bath. The permeabilities and selectivities of the prepared membranes depended on the concentrations of both polymers in the casting solution. The higher the concentration of PSf, the lower were the permeabilities to water and average pore sizes of the membranes. On the other hand, a very small amount of SPPO in the casting solution (about 1–4 wt % relative to the casting solution weight) brought about a considerable increase in water permeabilities and had a small influence on the average pore sizes. The effects were most pronounced if SPPO with a degree of sulfonation of 20–40% was used. The considerable increase in water permeabilities was explained by separation of the PSf and SPPO phases during precipitation in water and by the concentration of hydrophilic SPPO on the surface of the membrane and its pores. The determinations of the oriented concentration potentials proved the presence of a negative surface charge in the membranes. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 81: 134–142, 2001 相似文献
967.
2-Aminopyrimidine (2-ampym) and 4-aminopyrimidine (4-ampym) coordinate to W(CO)5 predominantly via the exocyclic amino group (>91% in 10 min photolysis) rather than to the endocyclic N-1 position as found for 2-aminopyridine (2-ampy). Photolysis of W(CO)6 in acetone in the presence of these ligands forms amino-bound [W(CO)5(2-ampym)] and [W(CO)5(4-ampym)] complexes. Secondary photolysis generates 18% (1.0 h photolysis) [W(CO)4(2-ampym)] or [W(CO)4(4-ampym)], chelated via the exocyclic amine and the adjacent endocyclic position (N-1 and N-3, respectively). Only ca. 10% of the more unhindered N-1-bound W(CO)5(4-ampym) was detected compared to virtually complete coordination via the exocyclic amino group for [W(CO)5(2-ampym)]. M
94 calculations show that the W(CO)5 coordination to the exocyclic donor is favored by 98.8 and 95.6 kcal/mol over the adjacent endocyclic position in the 2-ampym and 4-ampym complexes, respectively. Calculated W–N bond lengths by the M
94 methods gave exo-amine W–N bond distances of 2.24 and 2.26 Å and theoretical adjacent endocyclic W–N bond distances of 2.37 and 2.35 Å (isomers not observed from photolysis) for the 2-ampym and 4-ampym complexes, respectively. A W–(N-1) bond of 2.28 Å for this isomer of [W(CO)5(4-ampym)] was calculated. All W–N bonds are near the 2.18–2.33 Å range (mean of 2.27±0.06) for [W(CO)5L] (L=pyridine, piperidine, glycine, 1-(2-py)-1,2,4-triazole, [W(CO)5CN]−, 5-MeU−). 相似文献
968.
An Important aspect with respect to optimal mechanical performance of fiber reinforced composites in general and durability in particular is the optimization of the interfacial bond between fiber and polymer matrix. The quality of the fiber‐matrix interface is significant for the application of natural fibers as reinforcement for plastics. Since the fibers and matrices are chemically different, strong adhesion at their interfaces is needed for an effective transfer of stress and bond distribution throughout an Interface. A good compatibilization between cellulose fibers and non‐polar matrices is achieved from polymeric chains that will favor entanglements and interdiffiusion with the matrix. This article gives a critical review on the physical and chemical treatment methods that improve the fiber‐matrix adhesion and their characterization methods. 相似文献
969.
Influence of Serum and Hypoxia on Incorporation of [14C]-d-Glucose or [14C]-l-Glutamine into Lipids and Lactate in Murine Glioblastoma Cells 下载免费PDF全文
Glucose and glutamine are essential energy metabolites for brain tumor growth and survival under both normoxic and hypoxic conditions. Both metabolites can contribute their carbons to lipid biosynthesis. We used uniformly labeled [14C]‐U‐d ‐glucose and [14C]‐U‐l ‐glutamine to examine the profile of de novo lipid biosynthesis in the VM‐M3 murine glioblastoma cells. The major lipids synthesized included phosphatidylcholine (PtdCho), phosphatidylethanolamine (EtnGpl), phosphatidylinositol (PtdIns), phosphatidylserine (PtdSer), sphingomyelin (CerP Cho), bis(monoacylglycero)phosphate (BMP)/phosphatidic acid (PtdOH), cholesterol (C), cardiolipin (Ptd2Gro), and gangliosides. Endogenous lipid synthesis, using either glucose or glutamine, was greater in media without fetal bovine serum (FBS) than in media containing 10 % FBS under normoxia. De novo lipid synthesis was greater using glucose carbons than glutamine carbons under normoxia. The reverse was observed for most lipids under hypoxia suggesting an attenuation of glucose entering the TCA cycle. Lactate was produced largely from glucose carbons with minimal lactate derived from glutamine under either normoxia or hypoxia. Accumulation of triacylglycerols (TAG), containing mostly saturated and mono‐unsaturated fatty acids, was observed under hypoxia using carbons from either glucose or glutamine. The data show that the incorporation of labeled glucose and glutamine into most synthesized lipids was dependent on the type of growth environment, and that the VM‐M3 glioblastoma cells could acquire lipids, especially cholesterol, from the external environment for growth and proliferation. 相似文献
970.
NMR imaging of low pressure,gas‐phase transport in packed beds using hyperpolarized xenon‐129 下载免费PDF全文
Galina Pavlovskaya Joseph Six Thomas Meersman Navin Gopinathan Sean P. Rigby 《American Institute of Chemical Engineers》2015,61(11):4013-4019
Gas‐phase magnetic resonance imaging (MRI) has been used to investigate heterogeneity in mass transport in a packed bed of commercial, alumina, catalyst supports. Hyperpolarized 129Xe MRI enables study of transient diffusion for microscopic porous systems using xenon chemical shift to selectively image gas within the pores, and, thence, permits study of low‐density, gas‐phase mass‐transport, such that diffusion can be studied in the Knudsen regime, and not just the molecular regime, which is the limitation with other current techniques. Knudsen‐regime diffusion is common in many industrial, catalytic processes. Significantly, larger spatial variability in mass transport rates across the packed bed was found compared to techniques using only molecular diffusion. It has thus been found that that these heterogeneities arise over length‐scales much larger than ~100 µm. © 2015 American Institute of Chemical Engineers AIChE J, 61: 4013–4019, 2015 相似文献