Inflammation in the Human Periodontium Induces Downregulation of the α1- and β1-Subunits of the sGC in Cementoclasts

Nitric oxide (NO) binds to soluble guanylyl cyclase (sGC), activates it in a reduced oxidized heme iron state, and generates cyclic Guanosine Monophosphate (cGMP), which results in vasodilatation and inhibition of osteoclast activity. In inflammation, sGC is oxidized and becomes insensitive to NO. NO- and heme-independent activation of sGC requires protein expression of the α₁- and β₁-subunits. Inflammation of the periodontium induces the resorption of cementum by cementoclasts and the resorption of the alveolar bone by osteoclasts, which can lead to tooth loss. As the presence of sGC in cementoclasts is unknown, we investigated the α₁- and β₁-subunits of sGC in cementoclasts of healthy and inflamed human periodontium using double immunostaining for CD68 and cathepsin K and compared the findings with those of osteoclasts from the same sections. In comparison to cementoclasts in the healthy periodontium, cementoclasts under inflammatory conditions showed a decreased staining intensity for both α₁- and β₁-subunits of sGC, indicating reduced protein expression of these subunits. Therefore, pharmacological activation of sGC in inflamed periodontal tissues in an NO- and heme-independent manner could be considered as a new treatment strategy to inhibit cementum resorption.     

Information quality,user satisfaction,and the manifestation of workarounds: a qualitative and quantitative study of enterprise content management system users

In this paper, we focus on a critical aspect of work in organizations: using information in work tasks which is provided by information systems (IS) such as enterprise content management (ECM) systems. Our study based on the IS success model, 34 interviews, and an empirical study of 247 ECM system users at a financial service provider indicates that it is appropriate to differentiate between contextual and representational information quality as two information quality dimensions. Furthermore, we reveal that in addition to system quality, the two information quality dimensions are important in determining end-user satisfaction, which in turn influences the manifestation of workarounds. Our study also finds that employees using workarounds to avoid an ECM system implemented several years is negatively related to individual net benefits of the ECM system. Hence, we conclude that when investigating large-scale IS such as ECM systems, it is important to differentiate among information quality dimensions to more deeply understand end-user satisfaction and the resulting manifestation of workarounds. Moreover, this research guides organizations in implementing the most appropriate countermeasures based on the importance of either contextual or representational information quality.     

Partitioning of MCHP‐TES system run time to incorporate transient system behaviour: a comprehensive exergy‐based analysis using simulation

By combining heat and power generation, mini‐combined and micro‐combined heat and power systems (MCHP) provide an efficient, decentralised means of power generation that can complement the composition of the electricity generation mix. Dynamic tools capable of handling transient system behaviour are required to assess MCHP efficiency beyond a mere static analysis based on steady‐state design parameters. Using a simulation of a cogeneration system, we combine exergetic definitions for different operational system states to quantify the overall system efficiency continuously over the whole period of operation. The concept of exergy allows direct comparison of different forms of energy. A sensitivity analysis was performed where we quantified the effect on MCHP overall performance under varying engine rotational speed, thermal energy storage size and fluid storage temperature in a range of MCHP simulations. We found that the exergetic quantity of natural gas used by the MCHP decreased slightly at higher engine speeds (?2% to ?4%). While the total amount of electricity generated is almost constant across the range of different engine output, more thermal exergy (up to +21%) can be recovered when the engine is operating at elevated speeds. Furthermore, selection of specific optimal thermal storage fluid temperatures can aid in improving system efficiency. Copyright © 2016 John Wiley & Sons, Ltd.     

Nano-Design für Makroschichten

Nano design for macroscopic coatings – new application potentials by PVD coatings up to 100 μm thickness Non-homogeneous coatings still limit the application of thicker layers due to defect growth and irregular layer thickness distribution along the surface of complex shaped components. Therefore, the layer thickness is usually limited to about 10 μm. In order to limit the surface roughness by the growing layer, multilayer coating systems are deposited by highly ionized plasmas. This allows significantly smoother layers to be produced, which until now could only be produced by mechanical finishing. Furthermore, by combining selected material systems and targeted parameter selection, structures can be deposited during coating, especially on edges, which result in a reduction of the cutting edge radius. In future, edge geometries should therefore be able to be specifically adjusted through the coating process.     

Molecular Heterojunctions of Oligo(phenylene ethynylene)s with Linear to Cruciform Framework

Electrical transport properties of molecular junctions are fundamentally affected by the energy alignment between molecular frontier orbitals (highest occupied molecular orbital (HOMO) or lowest unoccupied molecular orbital (LUMO)) and Fermi level (or work function) of electrode metals. Dithiafulvene (DTF) is used as substituent group to the oligo(phenylene ethynylene) (OPE) molecular wires and different molecular structures based on OPE3 backbone (with linear to cruciform framework) are achieved, with viable molecular orbitals and HOMO–LUMO energy gaps. OPE3, OPE3–DTF, and OPE3–tetrathiafulvalene (TTF) can form good self‐assembled monolayers (SAMs) on Au substrates. Molecular heterojunctions based on these SAMs are investigated using conducting probe–atomic force microscopy with different tips (Ag, Au, and Pt) and Fermi levels. The calibrated conductance values follow the sequence OPE3–TTF > OPE3–DTF > OPE3 irrespective of the tip metal. Rectification properties (or diode behavior) are observed in case of the Ag tip for which the work function is furthest from the HOMO levels of the OPE3s. Quantum chemical calculations of the transmission qualitatively agree with the experimental data and reproduce the substituent effect of DTF. Zero‐bias conductance, and symmetric or asymmetric couplings to the electrodes are investigated. The results indicate that improved fidelity of molecular transport measurements may be achieved by systematic studies of homologues series of molecular wires applying several different metal electrodes.     

Towards garden city wonderlands: new town planning in 1950s Taiwan

This article explores the historical context, process and result of introducing and implementing ‘new’ town planning in early post‐war Taiwan. The two so‐called ‘garden cities’ are examined: Jhong‐Sing New Village and Yonghe City, both of which were formulated in the mid‐1950s by the same group of local planners. It reveals that the assumed necessity of importing Western planning paradigms arose from the abrupt escalation of urban concentration caused by the late 1940s mass migrations from China. To cope with this unprecedented population growth, planning profession was swiftly established. The novice planners, in search of a reference for developing ‘new’ towns to decentralise excessive urbanisation, modelled their ‘new’ town planning on English suburban morphology. In the absence of an input of external expertise, the planners appeared to mistake aesthetic order and pastoral imagery of low‐density residential development in England as practically viable solutions to the pressing urban problems in Taiwan. In a false hope that adopting Western ideas and practices would quickly lead the island to a better world, Taiwan initiated the importation of planning paradigms. This planning transfer not only evidently manifests a mode of ‘borrowing’ in post‐colonial countries in international diffusion but also re‐articulates the disseminating nature of modern planning and the existence of one‐direction flows characterising the global dynamics of diffusion in the twentieth century.