全文获取类型
收费全文 | 120篇 |
免费 | 10篇 |
专业分类
化学工业 | 59篇 |
金属工艺 | 2篇 |
机械仪表 | 1篇 |
建筑科学 | 4篇 |
能源动力 | 11篇 |
轻工业 | 4篇 |
水利工程 | 3篇 |
无线电 | 10篇 |
一般工业技术 | 19篇 |
冶金工业 | 4篇 |
自动化技术 | 13篇 |
出版年
2023年 | 2篇 |
2022年 | 10篇 |
2021年 | 8篇 |
2020年 | 3篇 |
2019年 | 7篇 |
2018年 | 6篇 |
2017年 | 1篇 |
2016年 | 3篇 |
2015年 | 4篇 |
2014年 | 10篇 |
2013年 | 8篇 |
2012年 | 10篇 |
2011年 | 6篇 |
2010年 | 8篇 |
2009年 | 7篇 |
2008年 | 6篇 |
2007年 | 3篇 |
2006年 | 6篇 |
2005年 | 5篇 |
2003年 | 4篇 |
2001年 | 1篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1994年 | 1篇 |
1991年 | 1篇 |
1982年 | 1篇 |
排序方式: 共有130条查询结果,搜索用时 31 毫秒
101.
Hanfeng Jin Alberto Cuoci Alessio Frassoldati Tiziano Faravelli Yizun Wang Yuyang Li Fei Qi 《Combustion and Flame》2014
In order to understand the interactions between butanol and hydrocarbon fuels in the PAH formation, experimental and kinetic modeling investigations were combined to study methane laminar coflow diffusion flames doped with two inlet mole fractions of n-butanol (1.95% and 3.90%) in this work. Mole fractions of flame species along the flame centerline were measured using synchrotron VUV photoionization mass spectrometry. A detailed kinetic model of n-butanol combustion, extended from a recent published n-butanol model, was provided in this work to reproduce the fuel decomposition and the formation of benzene and PAHs in the investigated flames. Numerical simulations were performed with laminarSMOKE code, a CFD code specifically conceived to handle large kinetic mechanisms. The simulation results were able to follow the observed effects of n-butanol addition from the experimental results. In particular, unsaturated hydrocarbons, especially C6–C16 aromatics, were predicted satisfactorily. The reaction flux analysis revealed that benzene precursors, especially C3 radicals, increase significantly with increasing inlet mole fraction of n-butanol. This enhances the formation of phenyl and benzyl radicals, which are important PAH precursors. Reactions of benzyl, phenyl radicals and benzene with C2–C3 species are the major formation pathways for indene and naphthalene. And PAHs with more carbon atoms are dominantly formed from naphthyl and indenyl radicals. 相似文献
102.
Mariafrancesca Scalise Gilda Pappacoda Tiziano Mazza Lara Console Lorena Pochini Cesare Indiveri 《International journal of molecular sciences》2022,23(3)
The plasma membrane transporter ASCT2 is a well-known Na+-dependent obligatory antiporter of neutral amino acids. The crucial role of the residue C467 in the recognition and binding of the ASCT2 substrate glutamine, has been highlighted by structure/function relationship studies. The reconstitution in proteoliposomes of the human ASCT2 produced in P. pastoris is here employed to unveil another role of the C467 residue in the transport reaction. Indeed, the site-directed mutant C467A displayed a novel property of the transporter, i.e., the ability of mediating a low but measurable unidirectional transport of [3H]-glutamine. This reaction conforms to the main features of the ASCT2-mediated transport, namely the Na+-dependence, the pH dependence, the stimulation by cholesterol included in the proteoliposome membrane, and the specific inhibition by other common substrates of the reconstituted human ASCT2. Interestingly, the WT protein cannot catalyze the unidirectional transport of [3H]-glutamine, demonstrating an unspecific phenomenon. This difference is in favor of a structural conformational change between a WT and C467A mutant that triggers the appearance of the unidirectional flux; this feature has been investigated by comparing the available 3D structures in two different conformations, and two homology models built on the basis of hEAAT1 and GLTPh. 相似文献
103.
Magdalena Lassinantti Gualtieri Elena Colombini Denia Mazzini Claudio Alboni Tiziano Manfredini Cristina Siligardi 《Journal of the European Ceramic Society》2018,38(16):5563-5568
Lightweight impermeable ceramic bodies were designed by combining pore templating and controlled viscous sintering through in-situ crystallization. Various amounts of limestone were added to a glass-fluxed low-temperature stoneware tile formulation. Closed porosity was created by decomposition of carbonates prior to sintering, thus leaving voids that were not completely filled by the viscous melt. The resulting oxides chemically modified the liquid phase and promoted the crystallization of β-wollastonite, diopside and anorthite. Hence, viscous sintering was affected. The addition of limestone brought on several advantages: the temperature of maximum sintering rate was decreased (<900?°C); the dimensional stability range was extended; the matrix was reinforced by newly-formed crystals that compensated for the global structure weakening evoked by increased porosity; an increase in whiteness was observed in concomitance to crystallization, reaching values only obtained when using zircon as opacifier (L*=87). 相似文献
104.
105.
106.
Maria Giulia Fabbrini Damiano Cirri Dr. Alessandro Pratesi Dr. Lorenzo Ciofi Dr. Tiziano Marzo Dr. Annalisa Guerri Dr. Silvia Nistri Alfonso Dell'Accio Tania Gamberi Dr. Mirko Severi Prof. Andrea Bencini Prof. Luigi Messori 《ChemMedChem》2019,14(1):182-188
The silver(I) N-heterocyclic carbene (NHC) complex bis(1-(anthracen-9-ylmethyl)-3-ethylimidazol-2-ylidene) silver chloride ([Ag(EIA)2]Cl), bearing two anthracenyl fluorescent probes, has been synthesized and characterized. [Ag(EIA)2]Cl is stable in organic solvents and under physiological conditions, and shows potent cytotoxic effects in vitro toward human SH-SY5Y neuroblastoma cells. The interactions of [Ag(EIA)2]Cl with a few model biological targets have been studied as well as its ability to be internalized in cells. The in vitro anticancer activity is apparently related to the level of drug internalization. Notably, [Ag(EIA)2]Cl does not react with a few model proteins, but is capable of binding the C-terminal dodecapeptide of thioredoxin reductase hTrxR(488–499) and to strongly inhibit the activity of this enzyme. Binding occurs through an unconventional process leading to covalent binding of one or two carbene ligands to the C-terminal dodecapeptide with concomitant release of the silver cation. To the best of our knowledge, this mode of interaction is reported here for the first time for Ag(NHC)2 complexes. 相似文献
107.
Anna Maria Ferrari Luisa Barbieri Cristina Leonelli Tiziano Manfredini Cristina Siligardi Anna Bonamartini Corradi 《Journal of the American Ceramic Society》1997,80(7):1757-1766
Basic principles of fabricating tile glazes based on cordi-eritic glass-ceramics are explained. Glass compositions from the MgO—Al2 O3 —SiO2 three-component phase dia-gram have been melted with and without the nucleating agent TiO2 . Additionally, a sodium borosilicate glass that is commonly used in the tile glaze industry has been wet milled, together with the previous compositions, to produce a coating slip. Studies are focused on the role of the nucle-ating agent and glassy formulation in the crystallization of the glass-ceramic system using differential thermal analysis, X-ray diffractometry, and scanning electron mi-croscopy. When added to a borosilicate glass, only one composition is capable of crystallizing cordierite under fast-firing cycle used for "monoporosa" production. The porosity of the glaze layer is sufficiently low and the crystal size is small to ensure good mechanical and chemical prop-erties. The presence of cordierite crystals in the glaze should enhance abrasion and acid resistance, in compari-son to a traditional matte glaze that contains mostly ensta-tite or diopside crystals. 相似文献
108.
Full integration of satellite technology in future terrestrial infrastructures requires support for high-quality broadband bi-directional communications. Research efforts in the field of satellite communications are currently oriented in the study of QoS-aware solutions for DVB–S and DVB–RCS which allow seamless deployment in the Internet. In this paper, the QoS architecture of the SATIP6 project, sponsored within the 5th EU Research Programme Framework, is presented, along with the implemented demonstrator and the obtained results. The QoS architecture is organized into two main modules, the Traffic Control and Access Control modules, whose aims are (i) to provide for differentiated service of conveyed IP flows and (ii) to achieve efficient utilization of uplink bandwidth, respectively. Experimental results obtained through the developed demonstration platform are reported and discussed to assess the effectiveness of the designed solution in terms of both service differentiation and efficient utilization of satellite resources. 相似文献
109.
Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells 下载免费PDF全文
Dr. Carlotta Granchi Dr. Yanrong Qian Dr. Hyang Yeon Lee Ilaria Paterni Carolina Pasero Jessica Iegre Kathryn E. Carlson Prof. Dr. Tiziano Tuccinardi Prof. Dr. Xiaozhuo Chen Prof. Dr. John A. Katzenellenbogen Prof. Dr. Paul J. Hergenrother Prof. Dr. Filippo Minutolo 《ChemMedChem》2015,10(11):1892-1900
The glucose transporter GLUT1 is frequently overexpressed in most tumor tissues because rapidly proliferating cancer cells rely primarily on glycolysis, a low‐efficiency metabolic pathway that necessitates a very high rate of glucose consumption. Because blocking GLUT1 is a promising anticancer strategy, we developed a novel class of GLUT1 inhibitors based on the 4‐aryl‐substituted salicylketoxime scaffold. Some of these compounds are efficient inhibitors of glucose uptake in lung cancer cells and have a notable antiproliferative effect. In contrast to their 5‐aryl‐substituted regioisomers, the newly synthesized compounds reported herein do not display significant binding to the estrogen receptors. The inhibition of glucose uptake in cancer cells by these compounds was further observed by fluorescence microscopy imaging using a fluorescent analogue of glucose. Therefore, blocking the ability of tumor cells to take up glucose by means of these small molecules, or by further optimized derivatives, may be a successful approach in the development of novel anticancer drugs. 相似文献
110.
Chiara Lambruschini Marina Veronesi Dr. Elisa Romeo Dr. Gianpiero Garau Dr. Tiziano Bandiera Prof. Dr. Daniele Piomelli Dr. Rita Scarpelli Dr. Claudio Dalvit 《Chembiochem : a European journal of chemical biology》2013,14(13):1611-1619
Despite the recognized importance of membrane proteins as pharmaceutical targets, the reliable identification of fragment hits that are able to bind these proteins is still a major challenge. Among different 19F NMR spectroscopic methods, n‐fluorine atoms for biochemical screening (n‐FABS) is a highly sensitive technique that has been used efficiently for fragment screening, but its application for membrane enzymes has not been reported yet. Herein, we present the first successful application of n‐FABS to the discovery of novel fragment hits, targeting the membrane‐bound enzyme fatty acid amide hydrolase (FAAH), using a library of fluorinated fragments generated based on the different local environment of fluorine concept. The use of the recombinant fusion protein MBP‐FAAH and the design of compound 11 as a suitable novel fluorinated substrate analogue allowed n‐FABS screening to be efficiently performed using a very small amount of enzyme. Notably, we have identified 19 novel fragment hits that inhibit FAAH with a median effective concentration (IC50) in the low mM –μM range. To the best of our knowledge, these results represent the first application of a 19F NMR fragment‐based functional assay to a membrane protein. 相似文献