GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness

Controlling the outer surface of nanometric metal–organic frameworks (nanoMOFs) and further understanding the in vivo effect of the coated material are crucial for the convenient biomedical applications of MOFs. However, in most studies, the surface modification protocol is often associated with significant toxicity and/or lack of selectivity. As an alternative, how the highly selective and general grafting GraftFast method leads, through a green and simple process, to the successful attachment of multifunctional biopolymers (polyethylene glycol (PEG) and hyaluronic acid) on the external surface of nanoMOFs is reported. In particular, effectively PEGylated iron trimesate MIL‐100(Fe) nanoparticles (NPs) exhibit suitable grafting stability and superior chemical and colloidal stability in different biofluids, while conserving full porosity and allowing the adsorption of bioactive molecules (cosmetic and antitumor agents). Furthermore, the nature of the MOF–PEG interaction is deeply investigated using high‐resolution soft X‐ray spectroscopy. Finally, a cell penetration study using the radio‐labeled antitumor agent gemcitabine monophosphate (³H‐GMP)‐loaded MIL‐100(Fe)@PEG NPs shows reduced macrophage phagocytosis, confirming a significant in vitro PEG furtiveness.     

A Hemispherical Image Sensor Array Fabricated with Organic Photomemory Transistors

Hemispherical image sensors simplify lens designs, reduce optical aberrations, and improve image resolution for compact wide-field-of-view cameras. To achieve hemispherical image sensors, organic materials are promising candidates due to the following advantages: tunability of optoelectronic/spectral response and low-temperature low-cost processes. Here, a photolithographic process is developed to prepare a hemispherical image sensor array using organic thin film photomemory transistors with a density of 308 pixels per square centimeter. This design includes only one photomemory transistor as a single active pixel, in contrast to the conventional pixel architecture, consisting of select/readout/reset transistors and a photodiode. The organic photomemory transistor, comprising light-sensitive organic semiconductor and charge-trapping dielectric, is able to achieve a linear photoresponse (light intensity range, from 1 to 50 W m⁻²), along with a responsivity as high as 1.6 A W⁻¹ (wavelength = 465 nm) for a dark current of 0.24 A m⁻² (drain voltage = −1.5 V). These observed values represent the best responsivity for similar dark currents among all the reported hemispherical image sensor arrays to date. A transfer method was further developed that does not damage organic materials for hemispherical organic photomemory transistor arrays. These developed techniques are scalable and are amenable for other high-resolution 3D organic semiconductor devices.     

Adaptive passive control with varying time delay

This paper presents a passive control scheme for a force reflecting bilateral teleoperation system with a varying time communication delay. To improve the stability and performance of the system, the master and slave must be coupled dynamically via a transmission network through which the force and velocity are communicated bilaterally. However, the time delay caused by various factors, such as the transmission distance, network congestion, and communication bandwidth, is a long-standing impediment to bilateral control that can destabilize the system. In this study, we investigated how a varying time delay affects the stability of a teleoperation system. A new optimal adaptive approach based on a passive control scheme was designed bilaterally for both the master and slave sites. Extra variables were transmitted together with the wave variables in the scattering system. The proposed scheme achieved both passive control, and an acceptable tracking performance. The tracking performance was demonstrated using a computer simulation of varying time delays in a bilateral teleoperation system.     

Unary finite automata vs. arithmetic progressions

We point out a subtle error in the proof of Chrobak's theorem that every unary NFA can be represented as a union of arithmetic progressions that is at most quadratically large. We propose a correction for this and show how Martinez's polynomial time algorithm, which realizes Chrobak's theorem, can be made correct accordingly. We also show that Martinez's algorithm cannot be improved to have logarithmic space, unless L = NL.     

Application of the OBD method for optimization of neural state variable estimators of the two-mass drive system

This paper presents neural estimators of the mechanical state variables of the electrical drive system with elastic joints. The non-measurable state variables, as the torsional torque and the load machine speed are estimated using multilayer feed-forward neural networks. The main stages of the design methodology of these neural estimators are presented. The optimal brain damage method is implemented for the structure optimization of each neural network. Then signals estimated by neural estimators are tested in the electrical drive control structure with additional feedbacks from the estimated shaft torque and the difference between the motor and the load speeds. The simulation results show good accuracy of both presented neural estimators for the wide range of changes of the reference speed and the load torque. The simulation results are then verified by laboratory experiments.     

Topology optimization for hybrid additive-subtractive manufacturing

Hybrid additive-subtractive manufacturing is gaining popularity by making full use of geometry complexity produced by additive manufacturing and dimensional accuracy derived from subtractive machining. Part design for this hybrid manufacturing approach has been done by trial-and-error, and no dedicated design methodology exists for this manufacturing approach. To address this issue, this work presents a topology optimization method for hybrid additive and subtractive manufacturing. To be specific, the boundary segments of the input design domain are categorized into two types: (i) Freeform boundary segments freely evolve through the casting SIMP method, and (ii) shape preserved boundary segments suppress the freeform evolvement and are composed of machining features through a feature fitting algorithm. Given the manufacturing strategy, the topology design is produced through additive manufacturing and the shape preserved boundary segments will be processed by post-machining. This novel topology optimization algorithm is developed under a unified SIMP and level set framework. The effectiveness of the algorithm is proved through a few numerical case studies.     

A socioeconomic model for managing water resources in Alicante,southeast Spain

The study analyzes variables that influence the water management model based on a simultaneous relationship between competing demands in the Marina Baja of Alicante, using a methodology that directly links together urban and irrigation demands, making them relevant to each other from a socioeconomic point of view. The paper identifies the relevant variables of this model and the agent behaviour in a closed and joint system. It also aims to demonstrate that by considering water demands for different yet simultaneous uses and regarding clean and reclaimed waters as integrated resources, the system could remain in equilibrium without external water supplies.     

A collaborative platform for cognitive decision making in the Knowledge Society

Two key aspects of the Knowledge Society are the interconnection between the actors involved in the decision making processes and the importance of the human factor, particularly the citizen’s continuous learning and education. This paper presents a new module devoted to knowledge extraction and diffusion that has been incorporated into a previously developed decision making tool concerning the Internet and related with the multicriteria selection of a discrete number of alternatives (PRIOR-Web). Quantitative and qualitative procedures using data and text mining methods have been employed in the extraction of knowledge. Graphical visualisation tools have been incorporated in the diffusion stage of the methodological approach suggested when dealing with decision making in the Knowledge Society. The resulting collaborative platform is being used as the methodological support for the cognitive democracy known as e-cognocracy.