When to use bit-wise neutrality

Representation techniques are important issues when designing successful evolutionary algorithms. Within this field the use of neutrality plays an important role. We examine the use of bit-wise neutrality introduced by Poli and López (2007) from a theoretical point of view and show that this mechanism only enhances mutation-based evolutionary algorithms if not the same number of genotypic bits for each phenotypic bit is used. Using different numbers of genotypic bits for the bits in the phenome we point out by rigorous runtime analyses that it may reduce the optimization time significantly.     

Potential and Limitations of Natural Chabazite for Selective Catalytic Reduction of NOx with NH3

The potential of the natural chabazite for the selective catalytic reduction (SCR) of NOx with NH₃ is evaluated in the present work. Activity tests were performed under technically relevant reaction and temperature conditions for the fresh and hydrothermally aged catalysts. The natural chabazite before and after alkaline removal as well as after iron and copper addition were compared. The structural as well as surface and bulk properties were elucidated by a variety of complementary characterization techniques, i.e. XRD, XPS, EPR, BET, NH₃‐TPD, ex situ and in situ XAS. The results indicate that an important facet for using the natural chabazite for the standard and fast SCR reactions is the removal of alkaline metals, which at the same time also leads to a partial change of the structure and the size of the iron‐containing particles. The performance and especially the hydrothermal stability can be further improved by copper addition.     

Aerosol Retention in the Vicinity of a Breach in a Tube Bundle: An Experimental Investigation

This article summarizes the main results of a bench-scale program focused on experimentally assessing the aerosol retention near the tube breach in a tube bundle. The major variables investigated were particle nature (polydispersed TiO ₂ agglomerates vs. solid, monodisperse SiO ₂ spheres) and Re _D (0.8?2.7· 10 ⁵ ). In addition, comparisons to other data sets provided insights into the particle aerodynamic size effect on retention efficiency. Results showed that particle nature substantially affects aerosol retention in the tube bundle: mass retention efficiency was low for TiO ₂ agglomerates (less than 30%) whereas it was much higher for SiO ₂ particles (around 85%). Retention efficiency is also affected by Re _D : its sensitivity was found to follow a log-normal behavior with a maximum retention attained at Re _D near 1· 10 ⁵ . This evolution with Re _D was similar for both types of compounds. Particle size also influences retention efficiency: the bigger the TiO₂ agglomerates the lower retention efficiency (no data were available for SiO ₂ ). Among all these variables, particle nature was noted to have a prime importance for in-bundle retention, whereas Re _D and particle aerodynamic size, although also affect retention efficiency, did not play such a key role. In light of the results, the presence of retention-inhibiting mechanisms such as fragmentation, resuspension or bouncing has been discussed. The data recorded will enhance the overall understanding of the governing mechanisms involved and will serve as a database against which compare model predictions. Nevertheless, further experimental data would be desirable to set up a sound database.     

Versuchsplanerische Untersuchung der Umesterung von Sojaöl mit Ethanol im Mikroreaktor

Base‐catalyzed transesterification of fats and oils with primary alcohols in discontinuous operation is an established batch process for the biodiesel production. However, the application of microreaction technology and continuous flow process lead to an increase of process intensification. The ethanol/soy bean oil ratio at low flow rates as well as the reactor geometry have the most evident effects on the fatty acid ethyl ester yield of KOH‐catalyzed ethanolysis of soy bean oil in microreactors. The influence of the catalyst concentration is of a lower importance.     

Identification and Structure–Activity Relationship Studies of Small‐Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1

The methyllysine reader protein Spindlin1 has been implicated in the tumorigenesis of several types of cancer and may be an attractive novel therapeutic target. Small‐molecule inhibitors of Spindlin1 should be valuable as chemical probes as well as potential new therapeutics. We applied an iterative virtual screening campaign, encompassing structure‐ and ligand‐based approaches, to identify potential Spindlin1 inhibitors from databases of commercially available compounds. Our in silico studies coupled with in vitro testing were successful in identifying novel Spindlin1 inhibitors. Several 4‐aminoquinazoline and quinazolinethione derivatives were among the active hit compounds, which indicated that these scaffolds represent promising lead structures for the development of Spindlin1 inhibitors. Subsequent lead optimization studies were hence carried out, and numerous derivatives of both lead scaffolds were synthesized. This resulted in the discovery of novel inhibitors of Spindlin1 and helped explore the structure–activity relationships of these inhibitor series.     

Multicriteria optimization as enabler for Sustainable Ceramic Matrix Composites

Over the past 40 years, development of Ceramic Matrix Composites (CMCs) has focused mainly on the improvement of material performance and optimization of cost-efficient production routes. Recently, more fields of application have opened up for CMCs, in which environmental impacts are relevant. These impacts have barely been investigated so far but receive growing interest due to increasing awareness of the environmental consequences. Our innovative approach frames material properties in relation to environmental impacts (e.g., global warming potential in CO₂ emission) by varying process parameters to balance optimum performance against environmental considerations. First, the process of wet filament winding has been investigated up to the Carbon Fiber Reinforced Plastic (CFRP) state by changing both the curing and tempering temperatures. During the production of CFRP plates, mass and energy flows were tracked in each step. Three point-bending and interlaminar shear tests have been performed on the resulting samples to identify basic mechanical properties. The environmental impacts are determined by a cradle-to-gate Life Cycle Assessment (LCA), using the software SimaPro. The resulting tradeoffs between mechanical properties and environmental impacts show nonlinear behavior, thus revealing optimum points above which improved mechanical properties are associated with significantly higher CO₂ emissions.