A blockchain-based approach for a multi-echelon sustainable supply chain

Blockchain technology is destined to revolutionise supply chain processes. At the same time, governmental and regulatory policies are forcing firms to adjust their supply chains in response to environmental concerns. The objective of this study is therefore to develop a distributed ledger-based blockchain approach for monitoring supply chain performance and optimising both emission levels and operational costs in a synchronised fashion, producing a better outcome for the supply chain. We propose the blockchain approach for different production allocation problems within a multi-echelon supply chain (MESC) under a carbon taxation policy. As such, we couple recent advances in digitalisation of operations with increasingly stringent regulatory environmental policies. Specifically, with lead time considerations under emission rate constraints (imposed by a carbon taxation policy), we simultaneously consider the production, distribution and inventory control decisions in a production allocation-based MESC problem. The problem is then formulated as a Mixed Integer Non-Linear Programming (MINLP) model. We show that the distributed ledger-based blockchain approach minimises both total cost and carbon emissions. We then validate the feasibility of the proposed approach by comparing the results with a non-dominated sorting genetic algorithm (NSGA-II). The findings provide support for policymakers and supply chain executives alike.     

Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response,Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice

Maternal obesity predisposes for hepato-metabolic disorders early in life. However, the underlying mechanisms causing early onset dysfunction of the liver and metabolism remain elusive. Since obesity is associated with subacute chronic inflammation and accelerated aging, we test the hypothesis whether maternal obesity induces aging processes in the developing liver and determines thereby hepatic growth. To this end, maternal obesity was induced with high-fat diet (HFD) in C57BL/6N mice and male offspring were studied at the end of the lactation [postnatal day 21 (P21)]. Maternal obesity induced an obese body composition with metabolic inflammation and a marked hepatic growth restriction in the male offspring at P21. Proteomic and molecular analyses revealed three interrelated mechanisms that might account for the impaired hepatic growth pattern, indicating prematurely induced aging processes: (1) Increased DNA damage response (γH2AX), (2) significant upregulation of hepatocellular senescence markers (Cdnk1a, Cdkn2a); and (3) inhibition of hepatic insulin/insulin-like growth factor (IGF)-1-AKT-p38-FoxO1 signaling with an insufficient proliferative growth response. In conclusion, our murine data demonstrate that perinatal obesity induces an obese body composition in male offspring with hepatic growth restriction through a possible premature hepatic aging that is indicated by a pathologic sequence of inflammation, DNA damage, senescence, and signs of a possibly insufficient regenerative capacity.     

Influence of Temperature on the Colloidal Stability of Polymer‐Coated Gold Nanoparticles in Cell Culture Media

The temperature‐dependence of the hydrodynamic diameter and colloidal stability of gold‐polymer core‐shell particles with temperature‐sensitive (poly(N‐isopropylacrylamide)) and temperature‐insensitive shells (polyallylaminine hydrochloride/polystyrensulfonate, poly(isobutylene‐alt‐maleic anhydride)‐graft‐dodecyl) are investigated in various aqueous media. The data demonstrate that for all nanoparticle agglomeration, i.e., increase in effective nanoparticle size, the presence of salts or proteins in the dispersion media has to be taken into account. Poly(N‐isopropylacrylamide) coated nanoparticles show a reversible temperature‐dependent increase in size above the volume phase transition of the polymer shell when they are dispersed in phosphate buffered saline or in media containing protein. In contrast, the nanoparticles coated with temperature‐insensitive polymers show a time‐dependent increase in size in phosphate buffered saline or in medium containing protein. This is due to time‐dependent agglomeration, which is particularly strong in phosphate buffered saline, and induces a time‐dependent, irreversible increase in the hydrodynamic diameter of the nanoparticles. This demonstrates that one has to distinguish between temperature‐ and time‐induced agglomerations. Since the size of nanoparticles regulates their uptake by cells, temperature‐dependent uptake of thermosensitive and non‐thermosensitive nanoparticles by cells lines is compared. No temperature‐specific difference between both types of nanoparticles could be observed.     

Ferroelectric Poling of Methylammonium Lead Iodide Thin Films

Seemingly contradictory reports on polar domains and their origin have surrounded the controversial discussion about the ferroelectricity of the methyl ammonium lead iodide (MAPbI₃) thin films that are commonly employed in perovskite solar cells. In this work, microscopic modulations of the polar domain patterns upon application of an electric poling field are correlated with macroscopic changes to the currents through the MAPbI₃ layer. Piezoresponse force microscopy is used to monitor the widening, narrowing, generation or extinction of polar domains, as well as shifts of the domain walls at room temperature under an in‐plane electric poling field that is applied between two laterally organized electrodes. This poling leads to a net polarization of individual grains and the thin film itself. Macroscopically, this net polarization results in a persistent shift of the diode characteristics that is measured across the channel between the electrodes. Both the modulation of the polar domains upon electric poling and the concurrent persistent shift of the electric currents through the device are the unambiguous hallmarks of ferroelectricity, which demonstrate that MAPbI₃ is a ferroelectric semiconductor.     

VPI-FP: an integrative information system for factory planning

Nowadays, one of the main challenges in factory planning is the consistent and coherent information modelling along planning processes. Despite the current efforts in the fields of virtual production as well as digital and virtual factory, planning and simulation applications mostly support only the analysis and the optimisation of single planning aspects. However, to match nowadays challenges, planners require solutions that provide an integrated view to evaluate planning scenarios in advance and to achieve increasing production quality and efficiency. The concept of virtual production intelligence (VPI) provides a basic concept for such an integrative information system that enables planners to integrate, to aggregate and to analyse data gathered during one planning project as well as to compare different projects. In this study, we present such an information system for factory planning using the concept of the VPI. The focus lies in particular on the information modelling as well as the information integration and evaluation. Therefore, the study presents theoretical basics and implementations of the VPI platform within a precise application scenario in factory planning. This is to process and provide a consolidated information base along the whole planning process to support factory planning projects.     

Carrot cropping on organic soil is a hotspot for nitrous oxide emissions

The emissions of the greenhouse gas nitrous oxide (N₂O) were measured from a non nitrogen fertilized carrot (Daucus carota ssp. sativa) field on an organic soil in Sweden during one cropping and post-harvest season. The cumulative emission during the measuring period of 149?days was 41 (±2.8) kg N₂O ha^?1. Dividing the measuring period into a cropping and a post-harvest period revealed that the presence of carrots strongly stimulated N₂O emissions, as the emission during the cropping period was one order of magnitude higher compared to the post-harvest period. The N₂O emission from the carrot field were higher than fluxes reported from cereal crop and grass production, but in the same order as reported fluxes from vegetable cropping on organic soils. In conclusion, our results indicate that the cultivation of root vegetable, such as carrots, on organic soil can be a high point source for N₂O emissions.