Mechanochemical solid-state polymerization. VIII. Novel composite polymeric prodrugs prepared by mechanochemical polymerization in the presence of pharmaceutical aids

We carried out the mechanochemical polymerization of methacryloyl derivatives of acetoaminophen and 5-fluorouracil in the presence of lactose. The reaction proceeded readily and the polymeric prodrugs were quantitatively produced. This method produces powdered polymeric prodrugs in which fine particles of lactose are homogeneously dispersed, since the reaction proceeds quantitatively through a totally dry process. It is difficult to prepare such a powdered polymeric prodrug by conventional solution polymerization. The rate of drug release of polymeric prodrugs increases with increasing content of lactose, as is shown to be true of the specific surface of polymeric prodrugs. These results suggest that lactose is homogeneously dispersed in powdered polymeric prodrugs. The present method seems applicable to a wide variety of pharmaceutical aids. If one takes the physiochemical property of pharmaceutical aids into consideration, novel polymeric prodrugs with a variety of drug release rates can be synthesized simultaneously with mixing.     

A study on product modelling for integration of CAD/CAM

Modelling capability for products to be designed and manufactured plays an important role in order to effectively construct and utilize CAD/CAM systems. Product models should represent all the information about products, which is utilized in manufacturing processes. Therefore it is required that they describe functional structures of machine products, and include not only geometric information but also various non-geometric data, such as physical, technological and management data. Presently there do not seem to exist definite methods or theories for constructing product models. In this paper, we first investigate the whole manufacturing process, and propose a system structure for integration of CAD/CAM, in which product modelling plays a fundamental role. Then requirements for product modelling are studied thoroughly, and a new representation framework for product models is proposed. It consists of an object concept called frame, relations among frames and attributes, and it can incorporate the existing various modelling capabilities, such as solid modelling. We use this representation framework in combination with our solid modelling package GEOMAP-III, and show the effectiveness of this approach by performing illustrative design experiments.     

13C NMR spectrum analysis of electrochemically prepared poly(3-methylthienylene) films

The ¹³C NMR spectrum analysis of electrochemically prepared poly(3-methylthienylene) films has been investigated. Both a film doped with ClO₄ ions (P3MT-ClO₄) and an undoped film (P3MT₀) give only two distinct absorption bands through the electrochemical reduction of P3MT-ClO₄. These distinct bands are definitely attributable to the methyl group (upper field) and the thiophene ring (lower field), respectively, and are characteristic of well-defined poly(3-methylthienylene). The correlation between conductivity and ¹³C NMR spectra will be discussed.     

13C NMR and Fourier transform infrared study of electrochemically prepared polythienylene film

The ¹³C NMR and Fourier transform infrared (FTIR) spectra of an electrochemically prepared polythienylene film have been obtained. The polythienylene film displays only two sharp absorption bands, at 124.8 and 136.5 ppm downfield from TMS (tetramethylsilane) in the ¹³C NMR, these being attributable to the carbon atoms in the β-position and the α-position, respectively, relative to the sulfur atom of poly(2,5-thienylene). The polythienylene film also shows a sharp absorption band at 789 cm^?1 in the IR, which is definitely ascribable to the C-H out-of-plane vibration of poly(2,5-thienylene). The polythienylene film will be shown to have a highly defined structure with a dominance of poly(2,5-thienylene).     

Contact force detection on a minute aperture mounted optical contact slider using an acoustic emission sensor

Advances in the digital network society require both higher density and higher transfer rates in all sorts of storage systems. Especially in optical recording, the trend toward higher density and larger capacity requires novel surface-recording technologies that can drastically diminish head-to-medium spacing, resulting in an improvement in spatial resolution and, finally, a higher recording density. To this end, we have already proposed a novel contact optical head slider that is able to almost cancel the suspension load by generating hydrodynamic pressure, thus realizing a lower net contact force. Evaluating the dynamic contact force is requisite in realizing its stable sliding operation and higher signal readout performance. In this study, a continuous acoustic emission (AE) signal was utilized to detect the dynamic contact force. AE signal modulation was compared with the applied out-of-plane acceleration on a medium generated by a spindle combined piezo-electric actuator. It was clarified that the detected AE modulation amplitude was approximately proportional to the applied acceleration, and that utilizing AE modulation will be a useful method for evaluating dynamic contact force.     

Electrical characteristics of micro mechanical contacts

 The electrical resistance of ultra-low-force contacts has been analyzed to aid in the fabrication of micromachined relays. The high-precision apparatus developed to measure contact resistance at extremely small contact forces uses an electronic analytical balance for force measurement and the four-point-probe method for resistance measurement. It has a precision of 1 μN for force measurement, 5 μN for force control, and 1 mΩ for resistance measurement. The force-resistance characteristics of gold, silver, and palladium electrical contacts were measured at a force of less than 4 mN. In the lower force region, the resistance decreased rapidly as the force increased. In the higher force region, the resistance become stable at a certain value. This stable resistance was proportional to material resistivity regardless of material type or electrode shape. The contact resistance and contact force of microrelays should be as small as possible. In all materials we studied, gold is the best material and the Kr gas sputtering and heating is the best depositing process offering the contact force of several hundred newton and the contact resistance less than 0.1 Ω. Received: 19 January 1996 / Accepted: 16 June 1996     

Dispersion of Verdet constant in stress-birefringent silica fibre

The Faraday effect in stress-birefringent silica fibre is discussed theoretically and measured experimentally. In the red and infra-red spectral range, the Verdet constant is found to be VH = 2.0 × 10?35 v2 rad/A, where v is the optical frequency in hertz.     

Detection of norovirus RNA in bivalve molluscs by using bacteria-culture-employed method (A3T method)

Norovirus (NV) RNA has rarely been detected in foods despite the use of highly sensitive methods such as RT-PCR and real-time RT-PCR. In the modified method (A3T method) reported previously, a bacterial culture process was introduced into the standard protocol for NV detection to remove some inhibitor(s) present in food ingredients. To confirm the efficiency of the A3T method and to examine NV contamination in bivalve molluscs, we tried to detect NV RNA in bivalve molluscs on the market and in oyster samples associated with foodborne outbreaks by using the standard method and the A3T method. NV RNAs were detected in 20 samples (18.0%) of 111 bivalve molluscs, including oysters, on the market by use of the A3T method, while only one sample (0.9%) was positive according to the standard method. NV RNA was also detected in 10 of 35 oyster samples related to foodborne outbreaks by the A3T method. Those results show that the A3T method is suitable for the detection of NV in bivalve molluscs in general laboratories.     

Humido-sensitive conducting polymer films and applications to linear actuators

Free-standing films made of poly(3,4-ethylenedioxythiophene) doped with poly(4-styrenesulfonate) (PEDOT/PSS) with various PSS contents were newly prepared by casting water dispersion of the PEDOT/PSS colloidal particles in the presence of an extra PSS. Electrical conductivity, morphology, water vapor sorption, and electro-active polymer actuating behavior of the resulting films were investigated by means of four-point method, atomic force microscope (AFM), sorption isotherm, and electromechanical analyses. The maximum contraction of the film by application of an electric field increased with increasing both PSS content and relative humidity (RH), where the value attained 7% at 70% RH for the film with 93% of PSS. Since the isothermal sorption curve of the film was less dependent on the PSS content, the significant increase of the film contraction was explained by two mechanisms: (i) the extra PSS prevented from hydrogen bonding between adjacent PEDOT/PSS particles that suppressed dimensional changes of the film; and (ii) the higher the RH, the larger the degree of water vapor sorption, which led to the large film contraction by desorption of water vapor via Joule heating. On the basis of this phenomenon linear actuators utilizing PEDOT/PSS films were successfully developed and applied to leverage actuator and Braille cell.     

Effects of oxygen content of porous titanium metal on its apatite-forming ability and compressive strength

Porous titanium metal subjected to NaOH and heat treatments is useful as a bone substitute as it shows high mechanical strength as well as osteoconductivity and osteoinductivity. However, the porous metal is liable to be contaminated with oxygen gas during the fabrication process and this incorporated oxygen could lead to adverse effects on the bioactivity and mechanical properties of the prepared porous body. In this study, oxygen contamination during fabrication of bioactive porous bodies was measured. It was found that the oxygen content of the titanium metal was increased from 0.08 to 0.23 mass% when the porous body was prepared from bar stock, and it further increased up to 0.51 mass% when it was subjected to NaOH and heat treatments. Despite this, the porous bodies subjected to NaOH and heat treatments formed apatite on their pore walls within 1 day in a simulated body fluid. This result was consistent with the apatite-forming ability of NaOH- and heat-treated titanium plates with different oxygen contents in the range of 0.05 to 0.30 mass%. The compressive strength of the porous body was increased about 10% by the NaOH and heat treatments.