Intraocular concentrations of chemotherapeutic agents after systemic or local administration

OBJECTIVES: To investigate the concentrations of carboplatin and etoposide achieved in the aqueous and vitreous humors after intravenous infusion in nonhuman primates, and to investigate whether local administration of carboplatin might result in higher concentrations in the vitreous humor. METHODS: Macaca fascicularis primates were treated with 1 of 3 regimens: (1) intravenous carboplatin (18.7 mg/kg), etoposide (5 mg/kg), and vincristine sulfate (0.05 mg/kg), (2) peribulbar carboplatin (10 mg/mL), or (3) episcleral balloon carboplatin (10 mg/mL). Concentrations of chemotherapeutic agents were measured in the plasma and in the aqueous and vitreous humors. RESULTS: No measurable amount of etoposide was detected in the aqueous or vitreous humor after intravenous administration. Mean measured peak vitreous concentration of carboplatin after intravenous administration was 0.31 microg/mL, which was 1% of the peak plasma value. Mean measured peak vitreous concentrations of carboplatin after peribulbar or episcleral balloon administration were 2.38 microg/mL and 2.95 microg/mL, respectively, which represent 7.68- and 9.52-fold increases over the concentration achieved after intravenous administration. No serious toxic effect was observed in any animal. CONCLUSIONS: Peribulbar and episcleral balloon administration of carboplatin seemed to be safe and resulted in higher vitreous concentrations than intravenous administration in this model. These results suggest that these alternate routes of delivery should be explored in children with vitreous seeding of retinoblastoma.     

本钢烧结矿冷却及其余热回收的试验研究

从烧结矿冷却并回收其余热的角度出发，介绍了利用烧结机尾落矿空间，采用喷吹空气装置对烧结矿进行冷却的小型模拟试验，从测出的结果来看，有可能成为一种新的烧结矿冷却方式。     

In situ synthesis of TiC-Al (Ti) nanocomposite powders by thermal plasma technology

A novel processing technology was developed to investigate in situ synthesis of TiC-Al (Ti) nanocomposite powders by thermal plasma technology. Thermodynamic analysis was performed to predict possible starting materials and synthesizing conditions of TiC-Al (Ti) nanocomposite powders. A mathematical model was developed to describe temperature profile and velocity distribution in the reactor. The model is applied to optimize feeding rate, input power, and other processing parameters of TiC-Al (Ti) nanocomposite powders by thermal plasma technology, and to predict which materials can be used as starting materials. This paper emphasizes the investigation of the effect of feeding rate, input power, mole ratio, and other process parameters on synthesis of TiC-Al (Ti) nanocomposite powders by thermal plasma technology. The experimental results showed that TiC-Al (Ti) nanocomposite powders can be synthesized in situ by thermal plasma technology, and the average size of TiC-Al (Ti) nanocomposite powders was less than 100 nm.     

单嘴精炼装置真空室内卷渣水模型研究

本文针对长城特殊厂单嘴精炼装置进行了真空室内加渣精炼的卷渣水模型研究。在试验的基础上，首先讨论了真空室内卷渣现象的工艺过程，然后进一步得出了临界吹气量的表达式。研究结果为工业性生产进一步提高钢的质量打下了基础。     

Effects of Sc2O3 and MgO passivation layerson the output power of AlGaN/GaN HEMTs

The low temperature (100°C) deposition of Sc₂O₃ or MgO layers is found to significantly increase the output power of AlGaN/GaN HEMTs. At 4 GHz, there was a better than 3 dB increase in output power of 0.5×100 μm² HEMTs for both types of oxide passivation layers. Both Sc₂ O₃ and MgO produced larger output power increases at 4 GHz than conventional plasma-enhanced chemical vapor deposited (PECVD) SiN_x passivation which typically showed ⩽2 dB increase on the same types of devices. The HEMT gain also in general remained linear over a wider input power range with the Sc₂O₃ or MgO passivation. These films appear promising for reducing the effects of surface states on the DC and RF performance of AlGaN/GaN HEMTs     

冶金能源信息库管理与能耗分析系统的研究

研究了通过计算机建立冶金能源信息库管理与能耗分析系统的相关问题。     

开发计算机管理信息系统推动设备供应管理现代化

本文介绍了我国冶金大型钢铁联合企业设备供应管理系统计算机应用开发过程及研制方法，并分析了取得的经济效益和在国内的推广价值。     

基于自组织神经网络的实时统计特征抽取方法

应用人工神经网络讨论统计了特征抽取的原理，提出了相应的抽取方法。该方法具有实时性，容错性，高数据压缩率和良好的特征分辨率。通过计算机仿真和桥梁索力状态的实例计算分析证实了该技术具有广泛的应用价值。