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111.
Abstract Under 24-GHz millimetre-wave irradiation heating ionic conductivity of zirconia base ceramics was up to 20 times higher than that of a conventionally-heated sample at the same temperature of 400 °C. The degree of enhancement could be altered by changing the stabilising atom from Y to Yb. Enhancement of ionic conduction was prominent in the setup condition of larger self-heating ratio and larger MMW absorbing materials. The isothermal improvement of ionic conductivity under MMW irradiation would be ascribed to the non-thermal effect. 相似文献
112.
Kenji Imai Koji Takai Tatsunori Hanai Makoto Shiraki Yusuke Suzuki Hideki Hayashi Takafumi Naiki Youichi Nishigaki Eiichi Tomita Masahito Shimizu Hisataka Moriwaki 《International journal of molecular sciences》2014,15(7):11294-11306
Obesity-related metabolic abnormalities, including adipokine imbalance and chronic inflammation, are involved in liver carcinogenesis. Chemerin, a novel adipokine, plays a critical role in adipogenesis, energy metabolism, and inflammation. We evaluated the impact of serum chemerin levels on liver functional reserves in hepatocellular carcinoma (HCC) patients and on the recurrence and prognosis of HCC. This study included 44 patients with any stage of HCC who underwent curative treatment at Gifu Municipal Hospital (Gifu, Japan) between 2006 and 2007. Recurrence-free survival and overall survival were estimated using the Kaplan-Meier method. Serum albumin levels (Pearson’s correlation coefficient; r = 0.3110, p = 0.0399), platelet counts (r = 0.4159, p = 0.0050), and prothrombin times (r = 0.3775, p = 0.0115) were significantly correlated with serum chemerin levels in patients with HCC, and they were inversely correlated with Child-Pugh scores (r = −0.3732, p = 0.0126), serum alanine aminotransferase levels (r = −0.3864, p = 0.0105), and total bilirubin levels (r = −0.4023, p = 0.0068). Among these variables, a multiple comparison test identified that platelet counts and total bilirubin levels were associated with serum chemerin levels (p < 0.0083). No significant correlation was found between serum chemerin levels and recurrence-free survival (p = 0.3691) or overall survival (p = 0.7916). In HCC patients, serum chemerin concentrations were correlated with liver functional reserves and platelet counts, but not with recurrence or prognosis. 相似文献
113.
Yoshihiro Hayashi Takuya Oishi Kaede Shirotori Yuki Marumo Atsushi Kosugi Shungo Kumada 《Drug development and industrial pharmacy》2018,44(7):1090-1098
Objectives: The aim of this study was to explore the potential of boosted tree (BT) to develop a correlation model between active pharmaceutical ingredient (API) characteristics and a tensile strength (TS) of tablets as critical quality attributes.Methods: First, we evaluated 81 kinds of API characteristics, such as particle size distribution, bulk density, tapped density, Hausner ratio, moisture content, elastic recovery, molecular weight, and partition coefficient. Next, we prepared tablets containing 50% API, 49% microcrystalline cellulose, and 1% magnesium stearate using direct compression at 6, 8, and 10?kN, and measured TS. Then, we applied BT to our dataset to develop a correlation model. Finally, the constructed BT model was validated using k-fold cross-validation.Results: Results showed that the BT model achieved high-performance statistics, whereas multiple regression analysis resulted in poor estimations. Sensitivity analysis of the BT model revealed that diameter of powder particles at the 10th percentile of the cumulative percentage size distribution was the most crucial factor for TS. In addition, the influences of moisture content, partition coefficients, and modal diameter were appreciably meaningful factors.Conclusions: This study demonstrates that BT model could provide comprehensive understanding of the latent structure underlying APIs and TS of tablets. 相似文献
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115.
Haruto Kumura Megumi Satoh Taiki Machiya Makoto Hosono Toru Hayakawa Jun‐ichi Wakamatsu 《International Journal of Dairy Technology》2019,72(3):403-408
The lipolytic and proteolytic activity of Penicillium camemberti PC TT033 and Penicillium roqueforti PR G3, cultured on the whey solids or simulated cheese media, were compared under several pH reaction conditions. Lipolytic activity was higher when both strains had been cultured on the whey medium than on the simulated cheese medium, whereas proteolytic activity was less influenced by the culture medium. The relationship between the reaction pH and these enzyme activities was dependent on the culture medium, which suggested that the expression level and balance of isozyme rely on the culture substrate. 相似文献
116.
Toru Moriyama Jun-ichi Mashiko Toshinori Matsui Koichiro Enomoto Tetsuya Matsui Kojiro Iizuka Masashi Toda Yukio Pegio Gunji 《Artificial Life and Robotics》2016,21(3):247-252
The soldier crab appears in great numbers and feeds while wandering during daytime low tide. When they see an approaching object, they screw themselves into the sand. The mechanism of formation of mass wandering has not been clarified. In this study, to investigate if the soldier crabs use visual images of neighbors as a stimulus for wandering, dummy crabs were presented to crabs. In the experiments, one, two, four, or eight dummies were placed in a circle on a sand arena. Each crab was placed in the center of the arena and observed whether it burrowed into the sand or wandered. The proportions of wandering individuals in each experimental treatment were compared with the expected value. Significantly more crabs were wanderers when only two and four dummies were present. This result suggests that soldier crabs chose burrowing or wandering depending on visual image of the distribution of the neighbors. 相似文献
117.
Shunsuke Kato Prof. Akira Onoda Naomasa Taniguchi Prof. Ulrich Schwaneberg Prof. Takashi Hayashi 《Chembiochem : a European journal of chemical biology》2021,22(4):679-685
Directed evolution of Cp*RhIII-linked nitrobindin (NB), a biohybrid catalyst, was performed based on an in vitro screening approach. A key aspect of this effort was the establishment of a high-throughput screening (HTS) platform that involves an affinity purification step employing a starch-agarose resin for a maltose binding protein (MBP) tag. The HTS platform enables efficient preparation of the purified MBP-tagged biohybrid catalysts in a 96-well format and eliminates background influence of the host E. coli cells. Three rounds of directed evolution and screening of more than 4000 clones yielded a Cp*RhIII-linked NB(T98H/L100K/K127E) variant with a 4.9-fold enhanced activity for the cycloaddition of acetophenone oximes with alkynes. It is confirmed that this HTS platform for directed evolution provides an efficient strategy for generating highly active biohybrid catalysts incorporating a synthetic metal cofactor. 相似文献
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119.
The thermally assisted machining of yttria-stabilized tetragonal zirconia polycrystal using a cutting tool heated with induction heating was proposed. Although the conventional thermally assisted machining cannot be applied to drilling, the proposed method can be. Heat transfer from the heated cutting tool to the workpiece was simulated analytically, and the result showed that heating of the tool up to 500 °C produced an increase of 150–400 °C in the workpiece temperature. Cutting experiments demonstrated an improvement in machinability. 相似文献
120.
Kenji Iwase Kazuhiro Mori Akinori Hoshikawa Toru Ishigaki 《International Journal of Hydrogen Energy》2012
The crystal structure and hydrogenation properties of Ce2Ni7-type Gd2Ni7 were investigated by X-ray diffraction (XRD) and the hydrogen pressure–composition (P–C) isotherm. Ce2Ni7-type Gd2Ni7 was obtained by annealing at 1523 K for 12 h and quenching in ice water. Two superlattice reflections (002 and 004) of the Ce2Ni7-type were clearly observed at 2θ = 7.3° and 14.6° in the XRD profile. The refined lattice parameters were a = 0.49662(9) nm and c = 2.4255(3) nm, respectively. Two plateaus were clearly observed during the absorption–desorption process in the P–C isotherm. The first and second plateaus were at 0.015 and 0.13 MPa, respectively, in the first desorption. The maximum hydrogen capacity reached was 1.13 H/M. The enthalpy and entropy were calculated as −20 kJ/mol H2 and −80 J/mol H2 K, respectively, from the van’t Hoff plot. After the P–C isotherm, the GdNi5 cell expanded by 2.15%, but the Gd2Ni4 cell shrank by 2.83%. 相似文献