Signaling through interleukin-6 receptor supports blast cell proliferation in acute myeloblastic leukemia

The purpose of this study was to examine the relationship between bone mineral density (BMD) and survival in both sexes and to compare BMD with other established risk factors such as blood pressure and cholesterol. A population-based prospective study of 1924 individuals (850 men, 1074 women) was performed in G?teborg from 1980 to 1983. Measurements of BMD were obtained in 1468 (76%) of the participants (653 men, 815 women). This selection of individuals generated 10,965 person years, and death was registered for 289 men and 197 women in the 7-year period (2661 days) after bone mineral measurement. Later information on date of death was obtained from the official population register. This information covers 7 years from the time of survey of the last examined participant (in Dec. 1983). At the beginning of the study, BMD was measured in the calcaneus by dual photon absorptiometry (DPA), and blood pressure, serum cholesterol, serum triglycerides, and body mass index (BMI) were also recorded. The study was coordinated with the National Register of Causes of Death and the National Cancer Register. A modified version of the Cox proportional hazards model was used to calculate and determine the age-adjusted relations between nontrauma mortality and BMD. When the various quartiles of BMD were compared prospectively from 70, 75, and 79 years of age with survival figures during the 2661-day follow-up period, the first and the second quartiles with the lowest BMD at entry showed the lowest survival rate in both men (P = 0.01) and women (P = 0.01). A decrease of 1 SD of BMD in a univariate analysis was associated with a 1.39-fold increase in mortality in both men (95% confidence interval 1.25-1.56, P < 0.001) and women (95% confidence interval 1.22-1.58, P < 0.001), and a multivariate analysis demonstrated a relative risk of 1.23 (95% confidence interval 1.10-1.41, P < 0.001) in men and 1.19 (95% confidence interval 1.02 to 1.39, P = 0.019) in women. All relations were adjusted for sex, age, and follow-up. This study indicates that BMD is a predictor of survival, especially for subjects over 70. Bone mineral density was found to be a better predictor of death than blood pressure and cholesterol. This study indicates that, after adjustments have been made for diseases, low bone mass is an independent predictor of mortality and might be a marker of general health or functional aging. Its measurement might therefore be a valuable tool in general health investigations.     

Degradative and mechanical properties of a novel resorbable plating system during a 3-year follow-up in vivo and in vitro

We tested the tissue reactions and mechanical strength of a novel biodegradable craniomaxillofacial plating system, Inion CPS™, in the course of degradation. Plates and screws composed of l-lactide, d-lactide and trimethylene carbonate were implanted to the mandible and dorsal subcutis of 12 sheep. The animals were sacrificed at 6–156 weeks. Histological evaluation was done using paraffin and methylmetacrylate techniques. Degradative and mechanical properties during the follow-up were measured both of in vivo and in vitro implants. In light microscopy, the in vivo implant material began to fragment at 52 weeks and could not be detected at 104 weeks. No significant foreign body reactions were seen in the mandibles. The dorsal subcutis disclosed mild reactions, which were, however, not of clinical significance. The implants in vitro maintained their entire mass for 26 weeks and lost 63–80% of the mass by week 104. The inherent viscosity of the implants in vitro and in vivo diminished uniformly. The screws retained their shear strength for 12–16 weeks. The plates maintained their tensile strength for at least 6 weeks. The maximum capacity of the plates in 3-point bending tests diminished gradually by 87% in 26 weeks. In conclusion, the plates and screws examined maintain adequate strength for the healing period of a bone fracture or osteotomy, producing no harmful foreign body reactions. Dr Nieminen is a consultant for Inion Ltd., while the other co-authors do not have any conflicts of interest. Inion Ltd. has financed the costs related to the study sheep, including their housing.     

High-performance 980-nm strained-layer GaInAs-GaInAsP-GaInP quantum-well lasers grown by all solid-source molecular-beam epitaxy

High-performance strained-layer GaInAs-GaInAsP-GaInP separate-confinement quantum-well lasers emitting at /spl lambda/=980 nm were grown by all solid-source molecular-beam epitaxy. Valved cracker cells were employed to generate group-V beam fluxes. Fabricated ridge-waveguide lasers exhibited stable, kink-free, single-mode operation up to 260 mW. A maximum output power of 550 mW was achieved. Complete thermal roll-over tests were done tens of times without any sign of degradation for p-side up-mounted lasers. Preliminary lifetime tests for over 4500 h at 150-mW power level indicate that these aluminum-free pump lasers are very reliable sources for pumping light into erbium-doped fiber amplifiers.     

Effects of a protein kinase C inhibitor, Ro 31-7549, on the activation of human leukocytes by particulate stimuli

1. A new specific protein kinase C (PKC) inhibitor, Ro 31-7549, was used to explore the mechanisms by which particulate stimuli, quartz and chrysotile, stimulate human polymorphonuclear leukocytes (PMNL) to produce reactive oxygen metabolites (ROM). Also soluble stimuli, formyl-Methionyl-Leucyl-Phenylalanine (fMLP) and phorbol myristate acetate (PMA) were used. 2. Ro 31-7549 inhibited chrysotile-induced free intracellular calcium ([Ca2+]i) elevations but did not have an effect on quartz-induced elevations of [Ca2+]i. Both quartz and chrysotile induced production of ROM were partially inhibited by Ro 31-7549. fMLP-induced elevation of [Ca2+]i was inhibited by Ro 31-7549 whereas PMA did not affect [Ca2+]i. Ro 31-7549 strongly inhibited fMLP-induced ROM production, and completely abolished that induced by PMA. 3. These result suggest that PKC may have an important role in the activation of PMNL to produce ROM by particulate and soluble stimuli. However, the inhibition of chrysotile-, but not of quartz-induced [Ca2+]i elevations by Ro 31-7549 provides evidence that both PKC-dependent and -independent mechanisms may play a role in the activation of human leukocytes to produce ROM.     

MIMO Detector for LTE/LTE-A Uplink Receiver

Journal of Signal Processing Systems - We propose a carefully selected receiver structure, detector and detector implementation architecture for multiple-input multiple-output (MIMO) uplink base...     

Docking-Based 3D-QSAR Studies for 1,3,4-oxadiazol-2-one Derivatives as FAAH Inhibitors

This work aimed to construct 3D-QSAR CoMFA and CoMSIA models for a series of 31 FAAH inhibitors, containing the 1,3,4-oxadiazol-2-one moiety. The obtained models were characterized by good statistical parameters: CoMFA Q² = 0.61, R² = 0.98; CoMSIA Q² = 0.64, R² = 0.93. The CoMFA model field contributions were 54.1% and 45.9% for steric and electrostatic fields, respectively. In the CoMSIA model, electrostatic, steric, hydrogen bond donor, and hydrogen acceptor properties were equal to 34.6%, 23.9%, 23.4%, and 18.0%, respectively. These models were validated by applying the leave-one-out technique, the seven-element test set (CoMFA r²_test-set = 0.91; CoMSIA r²_test-set = 0.91), a progressive scrambling test, and external validation criteria developed by Golbraikh and Tropsha (CoMFA r²₀ = 0.98, k = 0.95; CoMSIA r²₀ = 0.98, k = 0.89). As the statistical significance of the obtained model was confirmed, the results of the CoMFA and CoMSIA field calculation were mapped onto the enzyme binding site. It gave us the opportunity to discuss the structure–activity relationship based on the ligand–enzyme interactions. In particular, examination of the electrostatic properties of the established CoMFA model revealed fields that correspond to the regions where electropositive substituents are not desired, e.g., in the neighborhood of the 1,3,4-oxadiazol-2-one moiety. This highlights the importance of heterocycle, a highly electronegative moiety in this area of each ligand. Examination of hydrogen bond donor and acceptor properties contour maps revealed several spots where the implementation of another hydrogen-bond-donating moiety will positively impact molecules’ binding affinity, e.g., in the neighborhood of the 1,3,4-oxadiazol-2-one ring. On the other hand, there is a large isopleth that refers to the favorable H-bond properties close to the terminal phenoxy group of a ligand, which means that, generally speaking, H-bond acceptors are desired in this area.     

The role of surface modification in digital printing on polymer‐coated packaging boards

Digital printing is increasingly being used for package printing. One of the major techniques of digital printing is dry‐toner electrophotography. This paper evaluates the printability of three different extrusion coatings used for packaging boards: low‐density polyethylene (PE‐LD), ethylene methyl acrylate (E/MA) and polyethylene terephthalate (PET). Extrusion coatings in general have an impervious, chemically inert, nonporous surface with low surface energies that cause them to be non‐receptive to bonding with toners. The most common methods used in improving the adhesion properties of polymer coatings are different surface treatments. These increase the surface energy and also provide the polar molecular groups necessary for good bonds between the toner and polymer molecules. The polymer coatings have been modified with electrical corona discharge treatment. The effects of corona on polymer surfaces and the correlation between surface modification and print quality have been evaluated. Results show that sufficiently high surface energy and surface‐charge uniformity are necessary for even print quality and toner adhesion. E/MA and PET have the required surface‐energy level without the corona treatment, but PE‐LD needs surface modification in order to succeed in the electrophotographic process. E/MA also has exceptional surface‐charge properties compared with PET and PE‐LD. Polym. Eng. Sci. 44:2052–2060, 2004. © 2004 Society of Plastics Engineers.     

Impact of different forest densities on atmospheric boundary‐layer development and wind‐turbine wake

The aim of this work is to investigate the atmospheric boundary‐layer (ABL) flow and the wind turbine wake over forests with varying leaf area densities (LAD). The forest LAD profile used in this study is based on a real forest site, Ryningsnäs, located in Sweden. The reference turbine used to model the wake is a well‐documented 5‐MW turbine, which is implemented in the simulations using an actuator line model (ALM). All simulations are carried out with openFOAM using the Reynolds averaged Navier‐Stokes (RANS) approach. Twelve forest cases with leaf area index (LAI) ranging from 0.42 to 8.5 are considered. Results show that the mean velocity decreases with increasing LAI within the forest canopy, but increases with LAI above the hub height. Meanwhile, the turbulent kinetic energy (TKE) varies nonmonotonically with forest density. The TKE increases with forest density and reaches to its maximum at an average LAI of 1.70, afterwards, it decreases gradually as the density increases. It is also observed that the forest density has a clear role in the wake development and recovery. Comparisons between no‐forest and forest cases show that the forest characteristics help in damping the added turbulence from the turbine. As a consequence, the forest with the highest upstream turbulence has the shortest wake downstream of the turbine.     

多层柔性衬底电路板的低成本丝网印刷

当大批量生产多层聚合物基厚膜电路板时需要低成本的印刷技术.对于有超过6层导电层且不平滑的表面来说,丝网印刷是一个便宜、便捷的选择.为了研究丝网印刷技术的可行性,本研究在不同衬底材料的表面,如聚碳酸酯(PC)、聚酯(PET)、聚酰亚胺(PI)和液晶聚合物(LCP),使用同样的印刷分辨率,常规的厚膜网版印刷,通过丝网的网孔在衬底上形成精细图形.最后,研究在双层PI衬底(拥有2层导体层,在导体层的两侧有1层绝缘层覆盖板基孔)上的印刷.丝网印刷的导体材料是银基纳米颗粒油墨,介质层是聚酰亚胺基材料.许多变量是妨碍这种经济适用技术大规模生产应用的影响因素.例如,如果固化温度超过200℃,聚酰亚胺基板的稳定性就成为大问题.在本实验中,如果印刷面积小,层与层之间的对齐公差是允许的.然而,在印刷进行一段时间后,层与层之间的平整度会变差.测试用纳米粒子油墨是一种很好的导电系统,但是,当固化温度从230℃降低到200℃时,生产效率会受到极大影响.另一种实现多层结构的方法是层压法.本研究选择PET和PC层,重点是处理沉积胶层的PET层和片材的复合过程.多层结构中的板基孔和导线通过常规厚膜网印解决.先打孔,然后采用厚膜网印填补,最后印刷表面.层与层之间的黏合精度和对准精度<±15μm.     

Black carbon-inclusive modeling approaches for estimating the aquatic fate of dibenzo-p-dioxins and dibenzofurans

A novel black carbon (BC) inclusive modeling tool is applied to estimate the distribution and long-term fate of dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the Norwegian Grenland Fjords. Three versions of the model were developed in which sediment-water partitioning was described using (i) an amorphous organic carbon (AOC) partitioning sorption model without BC sorption, (ii) a combined AOC and BC sorption model based on the Freundlich isotherm, and (iii) a combined BC-AOC model based on the Langmuir isotherm. The predictive ability of the three different models was evaluated for 17 PCDD/Fs by comparison of model predictions with observed organic carbon normalized sediment-water partition coefficients (K(TOC)) and with measured concentrations. All three versions of the model were able to predict concentrations that were in reasonable agreement with measured particulate concentrations (i.e., within a factor of 4 of median values). Estimated particulate concentrations were less sensitive to the model choice because the majority of the mass of these hydrophobic chemicals is associated with particulates regardless. However, for estimation of K(TOC) or dissolved water concentrations, both versions of the combined AOC and BC sorption models provided greatly improved estimates compared to the AOC-only model.