A computational framework for scale‐bridging in multi‐scale simulations

A computational framework for scale‐bridging in multi‐scale simulations is presented. The framework enables seamless combination of at‐scale models into highly dynamic hierarchies to build a multi‐scale model. Its centerpiece is formulated as a standalone module capable of fully asynchronous operation. We assess its feasibility and performance for a two‐scale model applied to two challenging test problems from impact physics. We find that the computational cost associated with using the framework may, as expected, become substantial. However, the framework has the ability of effortlessly combining at‐scale models to render complex multi‐scale models. The main source of the computational inefficiency of the framework is related to poor load balancing of the lower‐scale model evaluation We demonstrate that the load balancing can be efficiently addressed by recourse to conventional load‐balancing strategies. Copyright © 2016 John Wiley & Sons, Ltd.     

Resolving force indeterminacy in contact dynamics using compatibility conditions

Contact dynamics (CD) is a powerful method to solve the dynamics of large systems of colliding rigid bodies. CD can be computationally more efficient than classical penalty-based discrete element methods (DEM) for simulating contact between stiff materials such as rock, glass, or engineering metals. However, by idealizing bodies as perfectly rigid, contact forces computed by CD can be non-unique due to indeterminacy in the contact network, which is a common occurence in dense granular flows. We propose a frictionless CD method that is designed to identify only the unique set of contact forces that would be predicted by a soft particle method, such as DEM, in the limit of large stiffness. The method involves applying an elastic compatibility condition to the contact forces, which maintains no-penetration constraints but filters out force distributions that could not have arisen from stiff elastic contacts. The method can be used as a post-processing step that could be integrated into existing CD codes with minimal effort. We demonstrate its efficacy in a variety of indeterminate problems, including some involving multiple materials, non-spherical shapes, and nonlinear contact constitutive laws.     

'98 Escherichia coli SWISS-2DPAGE database update

The combination of two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), computer image analysis and several protein identification techniques allowed the Escherichia coli SWISS-2DPAGE database to be established. This is part of the ExPASy molecular biology server accessible through the WWW at the URL address http://www.expasy.ch/ch2d/ch2d-top.html . Here we report recent progress in the development of the E. coli SWISS-2DPAGE database. Proteins were separated with immobilized pH gradients in the first dimension and sodium dodecyl sulfate-polyacrylamide gel electrophoresis in the second dimension. To increase the resolution of the separation and thus the number of identified proteins, a variety of wide and narrow range immobilized pH gradients were used in the first dimension. Micropreparative gels were electroblotted onto polyvinylidene difluoride membranes and spots were visualized by amido black staining. Protein identification techniques such as amino acid composition analysis, gel comparison and microsequencing were used, as well as a recently described Edman "sequence tag" approach. Some of the above identification techniques were coupled with database searching tools. Currently 231 polypeptides are identified on the E. coli SWISS-2DPAGE map: 64 have been identified by N-terminal microsequencing, 39 by amino acid composition, and 82 by sequence tag. Of 153 proteins putatively identified by gel comparison, 65 have been confirmed. Many proteins have been identified using more than one technique. Faster progress in the E. coli proteome project will now be possible with advances in biochemical methodology and with the completion of the entire E. coli genome.     

Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni

Periovular granuloma formation during Schistosoma mansoni infection is a complex, multifaceted immunologic response. Products of arachidonic acid metabolism have been shown to contribute to this response through studies in which general inhibitors of lipoxygenase function reduce granulomatous inflammation. To determine which lipoxygenases are important for granuloma development in schistosomiasis, wild type mice or mice deficient for 5-lipoxygenase (5-LO) or "leukocyte-type" 12-lipoxygenase (12-LO) were infected with S. mansoni and studied for responses to schistosome eggs and egg antigens. At the acute stage of infection, when granuloma formation is usually maximal, 5-LO deficient mice developed smaller granulomas around liver-deposited schistosome eggs compared with wild type or 12-LO deficient mice. 5-LO mice also displayed less antibody-mediated (5 h) and cell-mediated, delayed-type (24 h) hypersensitivity to schistosome egg antigens than did the other two infection groups. In an attempt to determine possible mechanisms for the reduced inflammatory responses, we also measured hepatic mRNA levels of cytokines that have been shown to influence granuloma size (IL-4, IL-10, and IFN-gamma). The mRNA levels for IL-10 were significantly lower in 5-LO-deficient mice, but SEA-stimulated spleen cells did not demonstrate a significant difference in IL-10 production between wild type and 5-LO mice. These data suggest that 5-LO plays a role in host responses to schistosomiasis via a mechanism that cannot be explained solely by changes in expression of these cytokines.     

Diode-Pumped Solid-State Lasers for Inertial Fusion Energy

We have begun building the Mercury laser system as the first in a series of new generation diode-pumped solid-state lasers for inertial fusion research. Mercury will integrate three key technologies: diodes, crystals, and gas cooling, within a unique laser architecture that is scalable to kilojoule and megajoule energy levels for fusion energy applications. The primary near-term performance goals include 10% electrical efficiencies at 10 Hz and 100J with a 2–10 ns pulse length at 1.047 m wavelength. When completed, Mercury will allow rep-rated target experiments with multiple chambers for high energy density physics research.     

Speech perception performance in experienced cochlear-implant patients receiving the SPEAK processing strategy in the Nucleus Spectra-22 cochlear implant

Sixteen experienced cochlear implant patients with a wide range of speech-perception abilities received the SPEAK processing strategy in the Nucleus Spectra-22 cochlear implant. Speech perception was assessed in quiet and in noise with SPEAK and with the patients' previous strategies (for most, Multipeak) at the study onset, as well as after using SPEAK for 6 months. Comparisons were made within and across the two test sessions to elucidate possible learning effects. Patients were also asked to rate the strategies on seven speech recognition and sound quality scales. After 6 months' experience with SPEAK, patients showed significantly improved mean performance on a range of speech recognition measures in quiet and noise. When mean subjective ratings were compared over time there were no significant differences noted between strategies. However, many individuals rated the SPEAK strategy better for two or more of the seven subjective measures. Ratings for "appreciation of music" and "quality of my own voice" in particular were generally higher for SPEAK. Improvements were realized by patients with a wide range of speech perception abilities, including those with little or no open-set speech recognition.     

Absolute figure measurements with a liquid-flat reference

We describe a variation of the liquid-flat technique fordetermining the absolute flatness of a 240-mm-diameter optical surfaceto an accuracy better than 1/100lambda in both its horizontal(three-point support) and vertical orientations. Using theappropriate mathematics to calculate the surface deformation of a diskdue to gravity, we achieved verification of the method by comparingmeasurements carried out on a pair of optical flats and a liquidreference surface.     

Spectrometer slit-power-coupling calculations for natural and laser guide-star adaptive optics

We use numerical calculations to examine the relation between adaptive optics (AO) turbulence compensation and power coupled through a spectrometer slit for both laser and natural guide-star AO systems. The AO system and observing parameters used are relevant to the Gemini-North 8-m telescope. For this study, we separate residual tilt from residual higher-order aberrations to isolate their relative effects under a variety of operating conditions. Our results demonstrate that slit-coupled intensity is not uniquely determined by system Strehl alone; we show that this is due to the differing effects of higher-order and tilt aberrations on the shape of the compensated point-spread function. For the Gemini spectrometer and AO system, the wider point-spread function halo associated with an added residual higher-order aberration reduces slit-coupled intensity more rapidly than a broad point-spread function core induced by residual tilt.     

The impact of system grounding practices on generator fault damage

Industry has become aware of the problem of severe generator damage due to stator ground faults. It has been suggested that, to prevent this damage, the practices employed for neutral grounding should be changed. This paper provides an analytical perspective on this problem and suggests that the real issue is the manner in which the neutral of the generator itself is grounded     

Design study of an infrared panoramic optical system

A design study was undertaken on an infrared, 3-5-μm, panoramic optical system for a particular monitoring application. The different types of systems investigated covered the conventional fish-eye lens system, a panoramic block arrangement, and a new type of configuration based on a panoramic shell. Examples of these systems are included, and their advantages and disadvantages are discussed.