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991.
Fan Gao Chi Zhang Wen‐Xiu Qiu Xue Dong Di‐Wei Zheng Wei Wu Xian‐Zheng Zhang 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(37)
Chemotherapy is well recognized to induce immune responses during some chemotherapeutic drugs‐mediated tumor eradication. Here, a strategy involving blocking programmed cell death protein 1 (PD‐1) to enhance the chemotherapeutic effect of a doxorubicin nanoprodrug HA‐Psi‐DOX is proposed and the synergetic mechanism between them is further studied. The nanoprodrugs are fabricated by conjugating doxorubicin (DOX) to an anionic polymer hyaluronic acid (HA) via a tumor overexpressed matrix metalloproteinase sensitive peptide (CPLGLAGG) for tumor targeting and enzyme‐activated drug release. Once accumulated at the tumor site, the nanoprodrug can be activated to release antitumor drug by tumor overexpressed MMP‐2. It is found that HA‐Psi‐DOX nanoparticles can kill tumor cells effectively and initiate an antitumor immune response, leading to the upregulation of interferon‐γ. This cytokine promotes the expression of programmed cell death protein‐ligand 1 (PD‐L1) on tumor cells, which will cause immunosuppression after interacting with PD‐1 on the surface of lymphocytes. The results suggest that the therapeutic efficiency of HA‐Psi‐DOX nanoparticles is significantly improved when combined with checkpoint inhibitors anti‐PD‐1 antibody (α‐PD1) due to the neutralization of immunosuppression by blocking the interaction between PD‐L1 and PD‐1. This therapeutic system by combining chemotherapy and immunotherapy further increases the link between conventional tumor therapies and immunotherapy. 相似文献
992.
Mónica Giménez‐Marqués Elena Bellido Thomas Berthelot Teresa Simón‐Yarza Tania Hidalgo Rosana Simón‐Vázquez África González‐Fernández José Avila Maria Carmen Asensio Ruxandra Gref Patrick Couvreur Christian Serre Patricia Horcajada 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(40)
Controlling the outer surface of nanometric metal–organic frameworks (nanoMOFs) and further understanding the in vivo effect of the coated material are crucial for the convenient biomedical applications of MOFs. However, in most studies, the surface modification protocol is often associated with significant toxicity and/or lack of selectivity. As an alternative, how the highly selective and general grafting GraftFast method leads, through a green and simple process, to the successful attachment of multifunctional biopolymers (polyethylene glycol (PEG) and hyaluronic acid) on the external surface of nanoMOFs is reported. In particular, effectively PEGylated iron trimesate MIL‐100(Fe) nanoparticles (NPs) exhibit suitable grafting stability and superior chemical and colloidal stability in different biofluids, while conserving full porosity and allowing the adsorption of bioactive molecules (cosmetic and antitumor agents). Furthermore, the nature of the MOF–PEG interaction is deeply investigated using high‐resolution soft X‐ray spectroscopy. Finally, a cell penetration study using the radio‐labeled antitumor agent gemcitabine monophosphate (3H‐GMP)‐loaded MIL‐100(Fe)@PEG NPs shows reduced macrophage phagocytosis, confirming a significant in vitro PEG furtiveness. 相似文献
993.
Étude O'Neel‐Judy Dylan Nicholls John Castañeda John G. Gibbs 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(32)
Using a dynamic fabrication process, hybrid, photoactivated microswimmers made from two different semiconductors, titanium dioxide (TiO2) and cuprous oxide (Cu2O) are developed, where each material occupies a distinct portion of the multiconstituent particles. Structured light‐activated microswimmers made from only TiO2 or Cu2O are observed to be driven in hydrogen peroxide and water most vigorously under UV or blue light, respectively, whereas hybrid structures made from both of these materials exhibit wavelength‐dependent modes of motion due to the disparate responses of each photocatalyst. It is also found that the hybrid particles are activated in water alone, a behavior which is not observed in those made from a single semiconductor, and thus, the system may open up a new class of fuel‐free photoactive colloids that take advantage of semiconductor heterojunctions. The TiO2/Cu2O hybrid microswimmer presented here is but an example of a broader method for inducing different modes of motion in a single light‐activated particle, which is not limited to the specific geometries and materials presented in this study. 相似文献
994.
The Influence of Carbon Nitride Nanosheets Doping on the Crystalline Formation of MIL‐88B(Fe) and the Photocatalytic Activities
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Zhen‐Dong Lei Yuan‐Cheng Xue Wen‐Qian Chen Lin Li Wen‐Hui Qiu Yong Zhang Liang Tang 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(35)
In this research, bulk graphitic carbon nitride (g‐C3N4) is exfoliated and transferred to the carbon nitride nanosheets (CNNSs), which are then coupled with MIL‐88B(Fe) to form the hybrid. From the results of the powder X‐ray diffraction, scanning electronic microscopy and thermogravimetric analysis, it is found that the doping of CNNSs on the surface of MIL‐88(Fe) could maintain the basic structure of MIL‐88B(Fe), and the smaller dimension of CNNSs might influence the crystallization process of metal‐organic frameworks (MOFs) compared to bulk g‐C3N4. Besides, the effects of the CNNSs incorporation on photocatalysis are also investigated. Through the photoluminescence spectra, electrochemical measurements, and photocatalytic experiments, the hybrid containing 6% CNNSs is certified to possess the highest catalytic activity to degrade methylene blue and reduce Cr(VI) under visible light. The improvement of the photocatalytic performance can be attributed to the matched energy level which favors the formation of the heterojunctions. Besides, it promotes the charge migration such that the contact between MOFs and CNNSs is more intimate, which can be inferred from the electronic microscopy images. Finally, a possible photocatalytic mechanism is put forward by the relative calculation and the employment of the scavengers to trap the active species. 相似文献
995.
996.
MXene Yarn Supercapacitors: High‐Performance Biscrolled MXene/Carbon Nanotube Yarn Supercapacitors (Small 37/2018)
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997.
Raman Scattering Mapping: Sensitive and Reproducible Immunoassay of Multiple Mycotoxins Using Surface‐Enhanced Raman Scattering Mapping on 3D Plasmonic Nanopillar Arrays (Small 39/2018)
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998.
Highly Uniform Resistive Switching Properties of Solution‐Processed Silver‐Embedded Gelatin Thin Film
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Yu‐Chi Chang Cheng‐Jung Lee Li‐Wen Wang Yeong‐Her Wang 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(13)
The silver‐embedded gelatin (AgG) thin film produced by the solution method of metal salts dissolved in gelatin is presented. Its simple fabrication method ensures the uniform distribution of Ag dots. Memory devices based on AgG exhibit good device performance, such as the ON/OFF ratio in excess of 105 and the coefficient of variation in less of 50%. To further investigate the position of filament formation and the role of each element, current sensing atomic force microscopy (CSAFM) analysis as well as elemental line profiles across the two different conditions in the LRS and HRS are analyzed. The conductive and nonconductive regions in the current map of the CSAFM image show that the conductive filaments occur in the AgG layer around Ag dots. The migration of oxygen ions and the redox reaction of carbon are demonstrated to be the driving mechanism for the resistive switching of AgG memory devices. The results show that dissolving metal salts in gelatin is an effective way to achieve high‐performance organic–electronic applications. 相似文献
999.
Green Synthesis of Hierarchically Porous Carbon Nanotubes as Advanced Materials for High‐Efficient Energy Storage
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Jian‐Gan Wang Hongzhen Liu Xingyuan Zhang Xu Li Xingrui Liu Feiyu Kang 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(13)
Hierarchically porous carbon nanomaterials with well‐defined architecture can afford a promising platform for effectively addressing energy and environmental concerns. Herein, a totally green and straightforward synthesis strategy for the fabrication of hierarchically porous carbon nanotubes (HPCNTs) by a simple carbonization treatment without any assistance of soft/hard templates and activation procedures is demonstrated. A high specific surface area of 1419 m2 g?1 and hierarchical micro‐/meso‐/macroporosity can be achieved for the HPCNTs. The unique porous architecture enables the HPCNTs serving as excellent electrode/host materials for high‐performance supercapacitors and Li–sulfur batteries. The design strategy may pave a new avenue for the rational synthesis of hierarchically porous carbon nanostructures for high‐efficient energy storage applications. 相似文献
1000.
An Electroactive and Transparent Haptic Interface Utilizing Soft Elastomer Actuators with Silver Nanowire Electrodes
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An electroactive and transparent haptic interface having a rectangular void pattern creates tunable surface textures by controlling the wavelength and amplitude of independent void‐lines. To make an active tactile surface, the transparent haptic interface employs a silver nanowire (AgNW) electrode to be compliant with the deformed elastomer surface. Here, the dielectric elastomer is newly blended with polydimethylsiloxane and Ecoflex prepolymer to simultaneously control the mechanical stiffness and transparency. The relative resistance of the AgNW electrode on a single void line is nearly unchanged under bending test, confirming the high stretchability and conductivity of the nanowire‐networked electrode. The optical transparencies are 92–85%, depending on the ratio of the Ecoflex solution. Transparency values decreas by 7 and 16% after coating with AgNWs at densities of 30 and 140 mg m?2, respectively. Using EP31, the void line is deformed by 90 µm under a field intensity of 13.0 V µm?1. The haptic surface is successfully controlled by applying voltage, which produces four different surface textures, from relatively smooth to rough feeling, depending on the distance between deformed void lines. This haptic interface can be applied to diverse display systems as an external add‐on screen and will help to realize programmable surface textures in the future. 相似文献