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11.
Polymeric substrate materials like polystyrene (PS), polycarbonate (PC) or cyclic olefins (COC) are getting more attention besides silica, glass and ceramic for the preparation of reaction vessels, optical slides, microfluidic components or microtiterplates in applications like medical diagnostics and pharmaceutical drug screening. Actually, the market of transparent polymeric chips is demanding the availability of modified surfaces with well defined arrays of wettable areas or special chemical functionalities. The modified areas are starting point to graft bioactive molecules, for instance proteins or DNA‐oligomers. Another application is pretreatment of adhesive bonded joints. Presently surface modifications are performed chemically and physically by plasma surface interaction. IWS has developed a new technique for dry chemical structuring of polymeric surfaces based on the principle of excimer laser irradiation in reactive gas atmosphere. This technique is characterized by a high resolution and a negligible amount of chemicals. The procedure consists of only a few processing steps, in contrast to conventional lithographic structuring methods. Also wetting problems do not play a role as they do in printing techniques. The technology provides the possibility of tailoring the chemical and topographical surface properties from ultrahydrophobic to hydrophilic or to functionalize areas of choice in the μm range with a chemical group of defined density. Using an excimer‐laser to induce reactions, mask imaging can be applied for microstructuring the surface with new properties, e. g. for microarrays. In addition, the laser allows defined amount of energy into the elementary reaction, according to the wavelength applied, which opens the possibility of replacing atoms in the polymer molecules by other atoms or molecules taken from an agent in the environment, in a selective way. The precondition is that both the polymer and the agent absorb the same wavelength. For instance 193 nm radiation (ArF excimer laser) is absorbed by polyolefines and by ammonia allowing an exchange of H atoms for amino groups by which the surface is changed to starting point to graft bioactive molecules. Chemical microstructures for instance amino group arrays have been realized on a variety of polymeric materials like cyclic olefin foil. This array of monofunctionality is the starting point for the preparation of parallel microreactors. These samples of topographical and chemical microstructures are the first step for biochemical preparations in medical diagnostic kits, DNA‐, protein‐ or cell biochips. The upscaling of the laser modification process in a multi‐chamber reactor offers the semicontinuous functionalization of polymers in pilot scale or in batch processing. On this basis the surface modification step can be adapted into a mass production line of “Lab‐on‐a‐chip” systems. 相似文献
12.
Udo Ziegler 《Computer Physics Communications》2004,157(3):207-216
I describe a Poisson solver for the adaptive mesh magnetohydrodynamics (MHD) code NIRVANA using ADI techniques (ADI: Alternative Direction Implicit). The solver is fit to the mesh refinement framework of the code and utilizes its special block-structured design. The key part of the method is an algorithm for the intelligent clustering of subgrids which permits the application of numerical methods based on dimensional operator splitting like ADI. Test problems show the convergence of this ansatz. 相似文献
13.
C Daumas-Duport ML Tucker H Kolles P Cervera F Beuvon P Varlet N Udo M Koziak JP Chodkiewicz 《Canadian Metallurgical Quarterly》1997,34(1):61-78
Myocardial perfusion scintigraphy is a noninvasive diagnostic method for the evaluation of patients with suspected or proven coronary artery disease (CAD). We utilized case-based reasoning (CBR) methods to develop the computer-based image interpretation system SCINA which automatically derives from a scintigraphic image data set an assessment concerning the presence of CAD. We compiled a case library of 100 patients who underwent both perfusion scintigraphy and coronary angiography to document or exclude the presence of CAD. The angiographic diagnosis of the retrieved nearest neighbor match of a scintigraphic input case was selected as the CBR diagnosis. We examined the effects of input data granularity, case indexing, similarity metric, and adaptation on the diagnostic accuracy of the CBR application SCINA. For the final prototype, sensitivity and specificity for detection of coronary heart disease were 98% and 70% suggesting that CBR systems may achieve a diagnostic accuracy that appears feasible for clinical use. 相似文献
14.
Erkan Aydin Michele De Bastiani Xinbo Yang Muhammad Sajjad Faisal Aljamaan Yury Smirnov Mohamed Nejib Hedhili Wenzhu Liu Thomas G. Allen Lujia Xu Emmanuel Van Kerschaver Monica Morales‐Masis Udo Schwingenschlgl Stefaan De Wolf 《Advanced functional materials》2019,29(25)
Parasitic absorption in transparent electrodes is one of the main roadblocks to enabling power conversion efficiencies (PCEs) for perovskite‐based tandem solar cells beyond 30%. To reduce such losses and maximize light coupling, the broadband transparency of such electrodes should be improved, especially at the front of the device. Here, the excellent properties of Zr‐doped indium oxide (IZRO) transparent electrodes for such applications, with improved near‐infrared (NIR) response, compared to conventional tin‐doped indium oxide (ITO) electrodes, are shown. Optimized IZRO films feature a very high electron mobility (up to ≈77 cm2 V?1 s?1), enabling highly infrared transparent films with a very low sheet resistance (≈18 Ω □?1 for annealed 100 nm films). For devices, this translates in a parasitic absorption of only ≈5% for IZRO within the solar spectrum (250–2500 nm range), to be compared with ≈10% for commercial ITO. Fundamentally, it is found that the high conductivity of annealed IZRO films is directly linked to promoted crystallinity of the indium oxide (In2O3) films due to Zr‐doping. Overall, on a four‐terminal perovskite/silicon tandem device level, an absolute 3.5 mA cm?2 short‐circuit current improvement in silicon bottom cells is obtained by replacing commercial ITO electrodes with IZRO, resulting in improving the PCE from 23.3% to 26.2%. 相似文献
15.
Manuel Lasch Kritika Sudan Corinna Paul Christian Schulz Thomas Kolben Julia van Dorp Sibel Eren Susanne Beyer Lorenzo Siniscalchi Sven Mahner Udo Jeschke Sarah Meister 《International journal of molecular sciences》2022,23(11)
(1) Background: Placental immune cells are playing a very important role in a successful placentation and the prevention of pregnancy complications. Macrophages dominate in number and relevance in the maternal and the fetal part of the placenta. The evidence on the polarization state of fetal and maternal macrophages involved in both, healthy and pregnancy-associated diseases, is limited. There is no representative isolation method for the direct comparison of maternal and fetal macrophages so far. (2) Material and Methods: For the isolation of decidual macrophages and Hofbauer cells from term placenta, fresh tissue was mechanically dissected and digested with trypsin and collagenase A. Afterwards cell enrichment was increased by a Percoll gradient. CD68 is represented as pan-macrophage marker, the surface markers CD80 and CD163 were further investigated. (3) Results: The established method revealed a high cell yield and purity of the isolated macrophages and enabled the comparison between decidual macrophages and Hofbauer cells. No significant difference was observed in the percentage of single CD163+ cells in the distinct macrophage populations, by using FACS and immunofluorescence staining. A slight increase of CD80+ cells could be found in the decidual macrophages. Considering the percentage of CD80+CD163− and CD80−CD163+ cells we could not find differences. Interestingly we found an increased number of double positive cells (CD80+CD163+) in the decidual macrophage population in comparison to Hofbauer cells. (4) Conclusion: In this study we demonstrate that our established isolation method enables the investigation of decidual macrophages and Hofbauer cells in the placenta. It represents a promising method for direct cell comparison, enzyme independently, and unaffected by magnetic beads, to understand the functional subsets of placental macrophages and to identify therapeutic targets of pregnancy associated diseases. 相似文献
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18.
Nathaniel A. Riordan Chaturvedi Gogineni Shane R. Johnson Xianfeng Lu Tom Tiedje Ding Ding Yong-Hang Zhang Rafael Fritz Kolja Kolata Sangam Chatterjee Kerstin Volz Stephan W. Koch 《Journal of Materials Science: Materials in Electronics》2012,23(10):1799-1804
Bulk and quantum well GaAs1?xBix/GaAs layers with Bi mole fractions from 0.02 to 0.10 are grown by molecular-beam epitaxy at temperatures ranging from 280 to 320?°C. The samples are characterized using temperature and pump-power dependent photoluminescence measurements covering 8–300?K and 1–250?mW (7–1,800?W/cm2), respectively. The results indicate that there is strong reduction in bandgap energy with the incorporation of small amounts of Bi and that GaAsBi most likely forms a weak type-I band alignment with GaAs. 相似文献
19.
Laura Unverdorben Thomas Haufe Laura Santoso Simone Hofmann Udo Jeschke Stefan Hutter 《International journal of molecular sciences》2016,17(5)
Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas. 相似文献
20.