In recent years some clinical reports have associated suture failures with polypropylene monofilaments. Therefore there is interest in developing an alternative suture material that is less thrombogenic than polyester and similar in handling characteristics but less prone to mechanical failure than polypropylene. To this end, Peters Laboratoire Pharmaceutique has developed a new monofilament suture material from polyvinylidene fluoride (PVDF), which has been subjected to a special treatment to modify its crystalline form and level of crystallinity. The purpose of this study was to evaluate its mechanical, chemical, and biologic properties and to compare its performance, in a peripheral vascular application, to that of a polypropylene control. A series of in vitro tests were performed to study the morphology, tensile properties, creep, surface chemistry, thermal characteristics, and resistance to iatrogenic trauma. In addition, an in vivo trial was undertaken in which vascular prostheses anastomosed with either PVDF or polypropylene sutures were implanted as a thoracoabdominal bypass for 6 months in the dog. Histologic and degradation analyses were performed on the explants. The results from the mechanical tests on 4-0, 5-0, and 6-0 PVDF and polypropylene sutures demonstrated that although both materials have similar breaking strengths, the PVDF has a higher extension at break, has less delayed extension when under tensile creep testing, and suffers less trauma than the polypropylene when compressed by a standard needle holder. While chemical analyses found evidence of surface oxidation on both types of sutures, thermal analysis confirmed that the level of crystallinity of the PVDF polymer is higher than that of the polypropylene control. During the pilot study in animals, PVDF sutures were found to have good handling and frictional characteristics that facilitated the tying of knots. Histologic analysis of the explants found no inflammatory cells in the tissue surrounding either the PVDF or polypropylene sutures, and scanning electron microscopic examination of the cleaned suture surfaces found no evidence of degradation during 6 months in vivo. Though preliminary in nature, these findings indicate that monofilament sutures made from PVDF provide an attractive alternative to those made from polypropylene for use in cardiovascular surgery. In addition to providing acceptable in vivo behavior and being easy to manipulate and more resistant to iatrogenic injury, PVDF materials can be sterilized by beta or gamma radiation and so can reduce dependence upon ethylene oxide and chlorofluorohydrocarbons. 相似文献
A differential reflectometry study was undertaken to investigate the characteristics of thin oxide films on metal substrates. The oxides were produced by heating pure metals of copper, tungsten, molybdenum and chromium in dry oxygen. A new “half polishing” technique was applied to obtain specimens with a step in oxide thickness in order to make them suitable for differential reflectometry. It was found that oxides formed this way yielded the same differential reflectograms as by electrochemical oxidation.A mathematical model involving the interaction of light with a thin corrosion product on metal substrates was applied to generate computer calculated differential reflectograms utilizing various optical constants and thicknesses of the assumed film. Three different thickness ranges have been identified. (a) For large film thicknesses, the differential reflectograms are distinguished by a sequence of interference peaks. (b) If the product of thickness and refraction index of the films is smaller than about 40 nm, no interference peaks are present. Any experimentally observed peaks in differential reflectograms of these films are caused entirely by electron interband transitions. (c) In an intermediate thickness range, superposition of interference and interband peaks are observed. 相似文献
A new measurement technique allows the continuous measurement of the oxygen contents of the wustite as a function of temperature without having to pass through the disintegration of the wustite to iron and magnetite and have the accompanying problems during the chemical analysis by cooling the sample. Measurements are carried out in form of isothermal oxygen reduction tests, starting with pure Fe2O3 in a thermogravimetric balance with an upstream gas mixer which, operating with CO2/CO gas mixtures, ensures a graduation of the input reduction potential CO'2 in steps of 1%. Simultaneous weighing of the test material sample permits, by means of the measured weight loss and relation to the charged amount of Fe2O3, a very accurate measurement of the oxygen concentration within the test material at any point in time during testing. Testing was carried out along these lines in the range between 700 and 1300°C. The results show that, at constant temperatures, the wustite oxygen contents decrease linearly from the right- to the left-hand boundary of the wustite field, with the oxygen pressure of the gas phase (log pCO2/pCO or log pO2). When comparing these results with the findings of Darken and Gurry, a difference becomes apparent in the curves of the log pO2 values as a function of the temperature. While our own curves are substantiated by very many measured values, the curves of Darken and Gurry are based on only twenty-three values at four different temperatures. Based on this result, systems of equations are developed which describe the homogeneous field of the wustite in the Fe-O-C reduction system without any gaps. An equivalent system of equations can also be developed from the values of a literature evaluation carried out by Giddings and Gordon. The curves resulting from the two equations do not differ very greatly. But the differences are large enough for corresponding variances to be expected when establishing the wustite boundaries and, thus, the position of the wustite field in the phase diagram. 相似文献
Gene expression in luteinizing hormone-releasing hormone (LHRH) neurons was analyzed during the periovulatory period to (1) characterize temporal patterns of LHRH gene expression and their relationship(s) to gonadotropin surges, and (2) determine if any such changes are uniform or dissimilar at different rostrocaudal levels of the basal forebrain. The number of neurons expressing mRNA for the decapeptide, and the relative degree of expression per cell were analyzed using in situ hybridization and quantitative image analysis. Rats were killed at 1800 hr on metestrus (Met), 0800 hr, 1200 hr, 1800 hr, and 2200 hr on proestrus (Pro), or 0200 hr, 0800 hr, and 1800 hr on estrus (E; n = 5-6 rats/group). All sections were processed for LHRH mRNA in a single in situ hybridization assay. Sections were atlas matched and divided into four rostrocaudal groups for analysis: vertical limb of the diagonal band of Broca (DBB), rostral preoptic area/organum vasculosum of the lamina terminalis (rPOA/OVLT), medial preoptic area (mPOA), and suprachiasmatic/anterior hypothalamic area (SCN/AHA). Plasma LH and FSH levels from all animals were analyzed by RIA. The labeling intensity per cell was similar among all time points at all four rostrocaudal levels. The number of cells expressing LHRH mRNA, however, varied as a function of time of death during the estrous cycle, and this temporal pattern varied among the four anatomical regions. At the level of the mPOA, the number of cells was highest at 1200 hr on Pro, and then declined and remained low throughout the morning of E. At the level of the rPOA/OVLT, the greatest number of LHRH neurons was noted later in Pro, at 1800 hr, dropping rapidly to lowest numbers at 2200 hr. No significant changes in LHRH cell number occurred at the DBB or SCN/AHA levels. At all anatomical levels, the secondary surge of FSH was unaccompanied by any change in the number of neurons expressing LHRH mRNA. These data demonstrate that (1) the number of detectable LHRH mRNA-expressing cells fluctuates during the periovulatory period and (2) peak numbers of LHRH-expressing cells are attained in the mPOA before the onset of the LH surge and before peak LHRH cell numbers are seen at more rostral levels. A model is proposed in which gene expression in this subpopulation of LHRH neurons may be activated by preovulatory estrogen secretion and acutely reduced following the proestrous surge of progesterone. 相似文献
Four first-lactation Holstein cows were used 65 to 177 days postpartum in a 4 × 4 Latin square trial to evaluate possible associative feeding effects between corn and haycrop silages. Nutrient digestibility and nitrogen and energy balances were studied. Diets were concentrate mixture, urea-treated corn silage, and early-cut, wilted haycrop silage in dry matter ratios of 55:45:0, 55:30:15, 55:15:30, and 55:0:45. Rations were offered just below energy balance in each 28-day period. Ration components were fed separately, concurrently, and twice daily. Crude protein in concentrate, corn silage, and hay crop silage dry matter was 16.9, 11.1, and 12.5%. Milk yield (18 to 19 kg) and ration dry matter intake (2.61% body weight) were not significantly different among diets. Apparent digestibility of gross energy, dry matter, protein, and fiber was not different among diets, but fat was more digestible in corn silage. Partition of ingested energy and nitrogen was not affected by treatments except that urine nitrogen was higher in corn silage. No associative feeding effects were significant. The two silages were equivalent in supporting milk production when fed in equal dry matter amounts. 相似文献
This paper, presented in two parts, assesses the potentialities and limitations of the deviation concept as applied to occupational accident control. A systems variable is classified as a deviation when its value falls outside a norm. In Part I, a systems model of accidents that incorporates the deviation concept is presented. Theories, models, terms, and taxonomies of the occupational accident research literature are analyzed in relation to this model in order to identify general elements. Theoretical and methodological problems concerning the definition of norms and taxonomies of deviations are discussed. In Part II measures of the significance of deviations with respect to the risk of accidents and criteria for the assessment of methods for the collection of data on deviations are operationalized. Empirical research on relations between deviations and accidents and on methods for data collection are reviewed on the basis of these measures and criteria. It is concluded that the deviation concept provides a valid basis for the design of information systems for the efficient control of accidents in production systems in operation. Considerations for the design of information systems for the collection, storing, processing, and feedback of information on deviations for accident prevention purposes are discussed. 相似文献
This article examines the formation of a high-speed gas dynamic flow ahead of a detonation wave in a channel. The shock-wave structure of the flow is described and the results of two-dimensional numerical calculations are given.Translated from Inzhenerno-Fizicheskii Zhurnal, Vol. 57, No. 2, pp. 262–269, August, 1989. 相似文献
Definition of the problem: The regulation of resident work hours involves several ethical conflicts which need to be systematically explicated and weighted. Arguments and conclusion: The most important ethical principle when regulating work hours is to avoid harm resulting from overwork of physicians and from extreme division of labour. Additionally, other ethical principles have to be taken into account, in particular those of non-maleficence and beneficence for future patients and for physicians. The article gives reasons for preferences when ethical principles are conflicting and analyses the structural difficulties that unavoidably occur in any regulation of complex activities like those of physicians. 相似文献
Development of real time in situ monitoring and control of thin film depositions using ellipsometry requires both data acquisition and processing to be rapid. Present speeds of measurement and computation of basic parameters, Ψ and Δ, are sufficient for data acquisition which is essentially real time. However, computation of film parameters, such as thickness and optical properties, generally cannot keep up with the incoming data and must be performed in a batch mode after the deposition.
This work describes the development of enhanced, high speed data reduction algorithms using artificial neural networks (ANN). The networks are trained using computed data and subsequently give values of film parameters in the millisecond time regime. The ANN outputs are used as initial estimates in a variably damped least squares algorithm for accuracy improvement. The combination of these two algorithms provides very accurate solutions in 75 ms per point on a DEC VAX 8800 multiprocessor system running at a combined 12 Mips. This speed is suitable for real time film monitoring and control for growth rates up to 10 nm per second. Results for fixed angle of incidence, single wavelength, in situ data for Ni deposited on BK7 substrates are presented. 相似文献