A rail transportable lead–bismuth cooled reactor

A conceptual design of a small reactor cooled by lead–bismuth is developed. The main constraint on this reactor design is its transportability. The whole reactor module should be transportable on a rail cart. This imposes a volume envelope of approximately 4.5 × 4.5 × 24 m and the maximum weight of about 300 tons. Therefore, the reactor vessel is 3 m in diameter and 3.85 m tall. In order to satisfy the proliferation resistance requirements the reactor is sealed after the fuel is loaded and shall not be opened until it is shipped back after it reaches its end of lifetime after 15years. The reactor fuel is 11% and 13% enriched plutonium nitride. Reactor power is 50 MW_th which translates into 15 MW_e. Reactor pool is at nearly atmospheric pressure. Core inlet and outlet temperature are 350 and 365 °C, respectively. The reactor uses electromagnetic pumps to drive the primary coolant circulation. Secondary system consists of saturated steam cycle operating at 7 MPa and 290 °C. This reactor is well suited for secluded areas with the demand for electricity such as small islands.     

Modeling and optimization of steam dryer for removal of lead–bismuth droplets

Removal of lead–bismuth droplets from steam flow is a crucial issue in the direct contact boiling lead–bismuth cooled fast reactor. Droplets are generated due to the boiling of water directly in the reactor chimney, where steam for the turbine is generated. The droplets could severely damage the turbine and therefore a steam dryer is used for their removal. This paper presents an optimization of the main steam dryer geometrical parameters and steam inlet velocity. The Lagrangian method is used, in which first the steam flow field is developed using the CFD code FrontFlow/Red and then the particle motion is simulated. It was found that the reduction of the plate spacing can improve the steam dryer performance without a significant increase of pressure drop, the wane pitch has a value after which the steam dryer performance is not significantly improved, the number of wanes of 1.5 was selected at this point, however, a more detailed model is necessary to arrive at the final conclusion. The optimum steam inlet velocity should be found using a detailed economical assessment. Velocities between 2 and 4 m/s seem to be reasonable to achieve good removal efficiency and keep the pressure drop at reasonable values.     

Titanium Dioxide Coatings Sprayed by a Water-Stabilized Plasma Gun (WSP) with Argon and Nitrogen as the Powder Feeding Gas: Differences in Structural, Mechanical and Photocatalytic Behavior

Titanium dioxide coatings were sprayed by a water-stabilized plasma gun to form robust self-supporting bodies with a photocatalytically active surface. Agglomerated nanometric powder was used as a feedstock. In one case argon was used as a powder-feeding as well as coating-cooling gas whereas in the other case nitrogen was used. Stainless steel was used as a substrate and the coatings were released after the cooling. Over one millimeter thick self-supporting bodies were studied by XRD, HR-TEM, XPS, Raman spectroscopy, UV-VIS spectrophotometry and photocatalytic tests. Selected tests were done at the surface as well as at the bottom side representing the contact surface with the substrate during the spray process. Porosity was studied by image analysis on polished cross sections where also microhardness was measured. The dominant phase present in the sprayed samples was rutile, whereas anatase was only a minor component. The hydrogen content in the nitrogen-assisted coating was higher, but the character of the optical absorption edge remained the same for both samples. Photoelectron spectroscopy revealed differences in the character of the O1s peak between both samples. The photocatalytic activity was tested by decomposition of acetone at UV illumination, whereas also the end products??CO and CO₂??were monitored. The nitrogen-assisted coating was revealed as a more efficient photocatalyst. Certain aspects of a thermal post-treatment on the coatings are discussed as well. Color and electrical conductivity are markedly changed at annealing at 760?°C, whereas only very small changes of the as-sprayed coating character correspond to annealing at 500?°C.     

High-rate reactive deposition of transparent SiO2 films containing low amount of Zr from molten magnetron target

The paper reports on a reactive deposition of transparent SiO₂ films with a low amount (≤ 3 at.%) of Zr prepared from the molten target using the AC pulsed dual magnetron. It is shown that the deposition rate a_D of the transparent oxide film strongly increases at the critical target power density (W_t)_cr when the solid target starts to melt and the magnetron operates with a molten target. In this case, the evaporation of target material plays a dominant role in the reactive deposition of thin films. This process is called the ionized magnetron evaporation. Oxide films reactively deposited from the molten target are well transparent and highly elastic. The maximum deposition rate of the transparent oxide film achieved in our experiments is 814 nm/min.     

Polyenic Antibiotics and Other Antifungal Compounds Produced by Hemolytic Streptomyces Species

Streptomyces are of great interest in the pharmaceutical industry as they produce a plethora of secondary metabolites that act as antibacterial and antifungal agents. They may thrive on their own in the soil, or associate with other organisms, such as plants or invertebrates. Some soil-derived strains exhibit hemolytic properties when cultivated on blood agar, raising the question of whether hemolysis could be a virulence factor of the bacteria. In this work we examined hemolytic compound production in 23 β-hemolytic Streptomyces isolates; of these 12 were soil-derived, 10 were arthropod-associated, and 1 was plant-associated. An additional human-associated S. sp. TR1341 served as a control. Mass spectrometry analysis suggested synthesis of polyene molecules responsible for the hemolysis: candicidins, filipins, strevertene A, tetrafungin, and tetrin A, as well as four novel polyene compounds (denoted here as polyene A, B, C, and D) in individual liquid cultures or paired co-cultures. The non-polyene antifungal compounds actiphenol and surugamide A were also identified. The findings indicate that the ability of Streptomyces to produce cytolytic compounds (here manifested by hemolysis on blood agar) is an intrinsic feature of the bacteria in the soil environment and could even serve as a virulence factor when colonizing available host organisms. Additionally, a literature review of polyenes and non-polyene hemolytic metabolites produced by Streptomyces is presented.     

Current Status of Cell-Based Therapy in Patients with Critical Limb Ischemia

(1) Background: The treatment of peripheral arterial disease (PAD) is focused on improving perfusion and oxygenation in the affected limb. Standard revascularization methods include bypass surgery, endovascular interventional procedures, or hybrid revascularization. Cell-based therapy can be an alternative strategy for patients with no-option critical limb ischemia who are not eligible for endovascular or surgical procedures. (2) Aims: The aim of this narrative review was to provide an up-to-date critical overview of the knowledge and evidence-based medicine data on the position of cell therapy in the treatment of PAD. The current evidence on the cell-based therapy is summarized and future perspectives outlined, emphasizing the potential of exosomal cell-free approaches in patients with critical limb ischemia. (3) Methods: Cochrane and PubMed databases were searched for keywords “critical limb ischemia and cell therapy”. In total, 589 papers were identified, 11 of which were reviews and 11 were meta-analyses. These were used as the primary source of information, using cross-referencing for identification of additional papers. (4) Results: Meta-analyses focusing on cell therapy in PAD treatment confirm significantly greater odds of limb salvage in the first year after the cell therapy administration. Reported odds ratio estimates of preventing amputation being mostly in the region 1.6–3, although with a prolonged observation period, it seems that the odds ratio can grow even further. The odds of wound healing were at least two times higher when compared with the standard conservative therapy. Secondary endpoints of the available meta-analyses are also included in this review. Improvement of perfusion and oxygenation parameters in the affected limb, pain regression, and claudication interval prolongation are discussed. (5) Conclusions: The available evidence-based medicine data show that this technique is safe, associated with minimum complications or adverse events, and effective.     

Immobilization of silver nanoparticles on polyethylene terephthalate

Two different procedures of grafting with silver nanoparticles (AgNP) of polyethylene terephthalate (PET), activated by plasma treatment, are studied. In the first procedure, the PET foil was grafted with biphenyl-4,4′-dithiol and subsequently with silver nanoparticles. In the second one, the PET foil was grafted with silver nanoparticles previously coated with the same dithiol. X-ray photoelectron spectroscopy and electrokinetic analysis were used for characterization of the polymer surface at different modification steps. Silver nanoparticles were characterized by ultraviolet-visible spectroscopy and by transmission electron microscopy (TEM). The first procedure was found to be more effective. It was proved that the dithiol was chemically bonded to the surface of the plasma-activated PET and that it mediates subsequent grafting of the silver nanoparticles. AgNP previously coated by dithiol bonded to the PET surface much less.     

Security threats to critical infrastructure: the human factor

In the twenty-first century, globalisation made corporate boundaries invisible and difficult to manage. This new macroeconomic transformation caused by globalisation introduced new challenges for critical infrastructure management. By replacing manual tasks with automated decision making and sophisticated technology, no doubt we feel much more secure than half a century ago. As the technological advancement takes root, so does the maturity of security threats. It is common that today’s critical infrastructures are operated by non-computer experts, e.g. nurses in health care, soldiers in military or firefighters in emergency services. In such challenging applications, protecting against insider attacks is often neither feasible nor economically possible, but these threats can be managed using suitable risk management strategies. Security technologies, e.g. firewalls, help protect data assets and computer systems against unauthorised entry. However, one area which is often largely ignored is the human factor of system security. Through social engineering techniques, malicious attackers are able to breach organisational security via people interactions. This paper presents a security awareness training framework, which can be used to train operators of critical infrastructure, on various social engineering security threats such as spear phishing, baiting, pretexting, among others.     

Atomistic simulations of dislocations and defects

This paper reviews selected recent research on the atomistic simulation of dislocation and defect properties of materials relevant to the multiscale modeling of plasticity and strength, with special emphasis on bcc metals and including work at extreme conditions. Current topics discussed include elasticity and ideal strength, dislocation structure and mobility, grain boundaries, point defects, and rapid resolidification, as well as noteworthy examples of research that directly impacts the issue of linking of length and/or time scales, as required in multiscale materials modeling. The work reviewed has been inspired by the recent international Workshop on Multiscale Modeling of Materials Strength and Failure held in October 2001 at Bodega Bay, California. This revised version was published online in June 2006 with corrections to the Cover Date.