电站设备评价认证系统数据库的设计研究

介绍了电站设备评价认证系统数据库设计研究的内容,讨论了数据库设计的过程,重点进行了数据库设计的需求分析。     

On education

The following observations are intended only to outline some concerns about, and to offer observations on, the teaching of design disciplines in the University of Buenos Aires and to rehearse the current educational challenges relating to achieving the standards expected of a professional graduate competent to improve our environmental demands.     

An environmental purpose artificial island off Belgium

Processing municipal and industrial wastes on land and particularly near inhabited centra has met with increased opposition. An apparent remedy to the problem is the establishment of such facilities offshore, hence various projects to build them on artificial islands. The paper examines a concrete proposal to locate such an island offshore from the Belgian Coast. Oceanographic and environmental aspects of the site are discussed, construction methods reviewed, erosion and corrosion effects looked at. The possibility of utilizing ocean power to provide the necessary operation energy is likewise considered.     

爆炸荷载作用下钢框架结构的爆破模拟分析

利用ANSYS/LS-DYNA有限元程序研究爆炸荷载作用下钢框架结构的连续性倒塌机理,主要针对3层4跨钢框架和5层4跨钢框架结构进行爆破拆除仿真模拟,根据不同的适用条件,分别针对定向倒塌方案、原地倒塌方案、内向倒塌方案和折叠倒塌方案进行模拟分析。分析结果表明:通过合理设置结构各参数和爆破点位置,可较为准确地模拟钢框架结构的爆破拆除过程,可用于钢结构爆破工程中爆破方案的模拟预测,并根据模拟结果对方案进行优化调整,为实际爆破工程提供技术支持。     

塑性滑坡安全状态的确定方法研究

为确定塑性滑坡变形过程中的安全状态,基于典型的塑性滑坡累计位移-时间曲线,提出采用曲线割线斜率作为滑坡发展阶段的判断标准。对于割线斜率-时间（S_t-t）曲线起始段斜率为负,且曲线急剧下降段,可断定为滑坡初始变形阶段;对于缓慢下降段,可认定为匀速变形段;对于总体趋势由负转正并且上升趋势确立的曲线,可将斜率为零的时间点定为滑坡由匀速变形向加速变形转变的临界点;对于加速变形向急剧变形转变的时间点,可采用当次割线斜率与邻近5次割线斜率比确定,采用连续两次割线斜率比第一次大2.0、比第二次大1.0作为滑坡进入急剧变形阶段的控制标准。根据实例,验证了上述方法的可行性和合理性。     

Towards the Search for Potential Biomarkers in Osteosarcoma: State-of-the-Art and Translational Expectations

Osteosarcoma represents a rare cause of cancer in the general population, accounting for <1% of malignant neoplasms globally. Nonetheless, it represents the main cause of malignant bone neoplasm in children, adolescents and young adults under 20 years of age. It also presents another peak of incidence in people over 50 years of age and is associated with rheumatic diseases. Numerous environmental risk factors, such as bone diseases, genetics and a history of previous neoplasms, have been widely described in the literature, which allows monitoring a certain group of patients. Diagnosis requires numerous imaging tests that make it possible to stratify both the local involvement of the disease and its distant spread, which ominously determines the prognosis. Thanks to various clinical trials, the usefulness of different chemotherapy regimens, radiotherapy and surgical techniques with radical intent has now been demonstrated; these represent improvements in both prognosis and therapeutic approaches. Osteosarcoma patients should be evaluated in reference centres by multidisciplinary committees with extensive experience in proper management. Although numerous genetic and rheumatological diseases and risk factors have been described, the use of serological, genetic or other biomarkers has been limited in clinical practice compared to other neoplasms. This limits both the initial follow-up of these patients and screening in populations at risk. In addition, we cannot forget that the diagnosis is mainly based on the direct biopsy of the lesion and imaging tests, which illustrates the need to study new diagnostic alternatives. Therefore, the purpose of this study is to review the natural history of the disease and describe the main biomarkers, explaining their clinical uses, prognosis and limitations.     

Overexpression of TcNTPDase-1 Gene Increases Infectivity in Mice Infected with Trypanosoma cruzi

Ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) are enzymes located on the surface of the T. cruzi plasma membrane, which hydrolyze a wide range of tri-/-diphosphate nucleosides. In this work, we used previously developed genetically modified strains of Trypanosoma cruzi (T. cruzi), hemi-knockout (KO +/−) and overexpressing (OE) the TcNTPDase-1 gene to evaluate the parasite infectivity profile in a mouse model of acute infection (n = 6 mice per group). Our results showed significantly higher parasitemia and mortality, and lower weight in animals infected with parasites OE TcNTPDase-1, as compared to the infection with the wild type (WT) parasites. On the other hand, animals infected with (KO +/−) parasites showed no mortality during the 30-day trial and mouse weight was more similar to the non-infected (NI) animals. In addition, they had low parasitemia (45.7 times lower) when compared with parasites overexpressing TcNTPDase-1 from the hemi-knockout (OE KO +/−) group. The hearts of animals infected with the OE KO +/− and OE parasites showed significantly larger regions of cardiac inflammation than those infected with the WT parasites (p < 0.001). Only animals infected with KO +/− did not show individual electrocardiographic changes during the period of experimentation. Together, our results expand the knowledge on the role of NTPDases in T. cruzi infectivity, reenforcing the potential of this enzyme as a chemotherapy target to treat Chagas disease (CD).