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171.
The mechanism of enhanced PVC impact strength of poly(vinyl chloride) modified by an acrylic graft copolymer was studied by the three-point bending test on a U-notched bar. In the mechanism, the void formation from the modifier released the constrained strain. The release suppresses the stress below the fibril strength in the material; consequently, stable deformation can develop over a large area and, thus, the impact strength of PVC modified by the acrylic graft copolymer is improved. © 1996 John Wiley & Sons, Inc. 相似文献
172.
In order to provide high performance silica gel for an adsorption heat pump (AHP), gels were synthesized using the sol-gel process modified with a new method of controlling the primary gel particle growth by the addition of aluminum ion. In this process, the pores of the silica gel synthesized became smaller when aluminum ion was added in the washing process. Furthermore, this silica gel adsorbed more water at a low region of water vapor pressure and its adsorption ability did not change after 100 repetitive times of adsorping/desorping water vapor. The experimental results from the water vapor adsorption on the silica gel agreed well with theoretical results obtained under the Lump model for heat transfer and intraparticle diffusion model for mass transfer. A new direct heat exchange silica gel module (DS-module) for the AHP was provided, and the heat transfer characteristics during the operation for the adsorption of water vapor were both experimentally and theoretically determined. The period of the adsorption for the DS-module was shorter than that for a silica gel/tube module. Therefore, with the addition of the DS-module the heat transfer in the AHP adsorber was sufficiently enhanced and the maximum heat generation power for the 2-mm-thick DS-module was obtained. © 1997 Scripta Technica, Inc. Heat Trans Jpn Res, 25(7): 420–433, 1996 相似文献
173.
Erin Vanessa LaRae Smith Rebecca Maree Dyson Christina M. G. Vanderboor Ousseynou Sarr Jane Anderson Mary J. Berry Timothy R. H. Regnault Lifeng Peng Clint Gray 《International journal of molecular sciences》2022,23(2)
Excess dietary fructose is a major public health concern, yet little is known about its influence on offspring development and later-life disease when consumed in excess during pregnancy. To determine whether increased maternal fructose intake could have long-term consequences on offspring health, we investigated the effects of 10% w/v fructose water intake during preconception and pregnancy in guinea pigs. Female Dunkin Hartley guinea pigs were fed a control diet (CD) or fructose diet (FD; providing 16% of total daily caloric intake) ad libitum 60 days prior to mating and throughout gestation. Dietary interventions ceased at day of delivery. Offspring were culled at day 21 (D21) (weaning) and at 4 months (4 M) (young adult). Fetal exposure to excess maternal fructose intake significantly increased male and female triglycerides at D21 and 4 M and circulating palmitoleic acid and total omega-7 through day 0 (D0) to 4 M. Proteomic and functional analysis of significantly differentially expressed proteins revealed that FD offspring (D21 and 4 M) had significantly increased mitochondrial metabolic activities of β-oxidation, electron transport chain (ETC) and oxidative phosphorylation and reactive oxygen species production compared to the CD offspring. Western blotting analysis of both FD offspring validated the increased protein abundances of mitochondrial ETC complex II and IV, SREBP-1c and FAS, whereas VDAC1 expression was higher at D21 but lower at 4 M. We provide evidence demonstrating offspring programmed hepatic mitochondrial metabolism and de novo lipogenesis following excess maternal fructose exposure. These underlying asymptomatic programmed pathways may lead to a predisposition to metabolic dysfunction later in life. 相似文献
174.
Sylvain Lamoine Mlissa Cumenal David A. Barriere Vanessa Pereira Mathilde Fereyrolles Laëtitia Prival Julie Barbier Ludivine Boudieu Emilie Brasset Benjamin Bertin Yoan Renaud Elisabeth Miot-Noirault Marie-Ange Civiale David Balayssac Youssef Aissouni Alain Eschalier Jrme Busserolles 《International journal of molecular sciences》2022,23(1)
175.
Barbara Eleni Rosato Roberta Marra Vanessa DOnofrio Federica Del Giudice Simone Della Monica Achille Iolascon Immacolata Andolfo Roberta Russo 《International journal of molecular sciences》2022,23(3)
Biallelic pathogenic variants in the SEC23B gene cause congenital dyserythropoietic anemia type II (CDA II), a rare hereditary disorder hallmarked by ineffective erythropoiesis, hemolysis, erythroblast morphological abnormalities, and hypo-glycosylation of some red blood cell membrane proteins. Abnormalities in SEC23B, which encodes the homonymous cytoplasmic COPII (coat protein complex II) component, disturb the endoplasmic reticulum to Golgi trafficking and affect different glycosylation pathways. The most harmful complication of CDA II is the severe iron overload. Within our case series (28 CDA II patients), approximately 36% of them exhibit severe iron overload despite mild degree of anemia and slightly increased levels of ERFE (the only erythroid regulator of hepcidin suppression). Thus, we hypothesized a direct role of SEC23B loss-of-function in the pathomechanism of hepatic iron overload. We established a hepatic cell line, HuH7, stably silenced for SEC23B. In silenced cells, we observed significant alterations of the iron status, due to both the alteration in BMP/SMADs pathway effectors and a reduced capability to sense BMP6 stimulus. We demonstrated that the loss-of-function of SEC23B is responsible of the impairment in glycosylation of the membrane proteins involved in the activation of the BMP/SMADs pathway with subsequent hepcidin suppression. Most of these data were confirmed in another hepatic cell line, HepG2, stably silenced for SEC23B. Our findings suggested that the pathogenic mechanism of iron overload in CDA II is associated to both ineffective erythropoiesis and to a specific involvement of SEC23B pathogenic variants at hepatic level. Finally, we demonstrated the ability of SEC23B paralog, i.e., SEC23A, to rescue the hepcidin suppression, highlighting the functional overlap between the two SEC23 paralogs in human hepatic cells. 相似文献
176.
Nassim Sahboun Kazuhiro Sawa Yasunori Yamamoto Yuta Watanabe Tomomasa Ito 《Journal of Nuclear Science and Technology》2020,57(9):1111-1120
ABSTRACT In the event of a severe accident, past experiences such as Three Mile Island and Fukushima Daichi have shown that the reactor core of a light-water nuclear reactor, if not properly safeguarded, could go through a meltdown. This will be followed by the formation of a corium, a mix of molten fuel elements, and liquid metals from the Reactor Pressure Vessel (RPV). In the worst-case scenario, a melt through from the RPV can occur and lead to the spreading of the corium, in the form of a molten element’s jet impinging on a flat concrete structure of the Primary Containment Vessel (PCV). To enhance the decommissioning and the safety procedure, scope of the present article is to deepen the understanding of the phenomena involved in the mentioned scenario, mainly jet-instability and molten material spreading. In the present study, experiments were carried out, by using corium simulant materials such as Copper and Tin, to investigate the link between the instability of the gravity-driven molten metal jet and the impinging followed by its spreading over a flat area. 相似文献
177.
Talc-containing polypropylene (PP) resin is extensively employed in automobiles. Herein, considering the microstructure transfer process in injection molding, the effect of the talc's dispersibility and particle size on this process and its impact on the gloss level of the product were investigated. Results show that a fine unevenness of about several micrometers was self-formed by the shrinkage of PP in nontransferred areas due to the blending of talc. Additionally, the amount of self-formed unevenness tended with an increase in the average particle size of talc. Furthermore, due to PP shrinkage and different densities of talc, it was observed that a fine tiger-stripe pattern was self-formed using special molds with modified microstructure. This self-formed fine unevenness changes the gloss level owing to the diffused light reflection effect. This study proposes controlling this change by controlling the average particle size of talc and structure of the mold. POLYM. ENG. SCI., 60:132–139, 2020. © 2019 Society of Plastics Engineers 相似文献
178.
179.
Shoji Eita Takahashi Ryuji Isogai Shosei Ito Naoto Kubo Masaki Tsukada Takao Fukuyama Hiroyuki 《Metallurgical and Materials Transactions B》2019,50(5):2454-2458
Metallurgical and Materials Transactions B - Normal spectral emissivity of molten Cu-Fe alloy with different compositions was measured at the wavelength of 807 nm using an electromagnetic... 相似文献
180.
In monocarpic plants, stem cells are fated to die. However, the potential mechanism of stem cell death has remained elusive. Here, we reveal that the levels of two forms of reactive oxygen species (ROS), superoxide anion free radical () and hydrogen peroxide (H2O2), show dynamic changes in the shoot apex during the plant life cycle of Arabidopsis thaliana. We found that the level of decreased and disappeared at four weeks after bolting (WAB), while H2O2 appeared at 3 WAB and showed a burst at 5 WAB. The timing of dynamic changes in and H2O2 was delayed for approximately three weeks in clv3-2, which has a longer lifespan. Moreover, exogenous application of H2O2 inhibited the expression of the stem cell determinant WUSCHEL (WUS) and promoted the expression of the developmentally programmed cell death (dPCD) marker gene ORESARA 1 (ORE1). These results indicate that H2O2 triggers an important signal inducing dPCD in stem cells. Given that plays roles in maintaining WUS expression and stem cell activity, we speculate that the dynamic shift from to H2O2 in the shoot apex results in stem cell death. Our findings provide novel insights for understanding ROS-mediated regulation during plant stem cell death. 相似文献