Targeted Nanoparticle‐Mediated Gene Therapy Mimics Oncolytic Virus for Effective Melanoma Treatment

Oncolytic virus has potential applications in cancer therapy. However, its clinical application is restricted by the virus‐associated biosafety issues. Here, inspired by the key role of vesicular stomatitis virus matrix protein (VSVMP) in the oncolytic vesicular stomatitis virus (VSV) induced apoptosis, a targeted nanoparticle‐delivered neutral VSVMP gene formulation is designed to act like the VSV for cancer therapy. This VSVMP formulation consists of a CRGDKGPDC peptide modified hybrid monomethoxy poly (ethylene glycol)‐poly(d ,l ‐lactide) nanoparticles complexed with VSVMP plasmid, having good blood compatibility and tumor targeting ability. The transfection efficiency is as high as that of VSV. After intravenous administration, the VSVMP formulation can efficiently target the tumor, significantly inhibit the melanoma growth and metastasis, prolong the survival time of tumor‐bearing mice, and does not cause obvious systemic toxicity. The anticancer mechanisms involve apoptosis induction, angiogenesis inhibition and some virus‐associated signal pathways activation. This work demonstrates a VSV‐inspired nonviral gene therapy that has promising clinical applications in melanoma treatment.     

A parametric method for non-stationary interference suppression in direct sequence spread-spectrum systems

The problem of non-stationary interference suppression in direct sequence spread-spectrum (DS-SS) systems is considered. The phase of interference is approximated by a polynomial within the considered interval. According to the local polynomial Fourier transform (LPFT) principle, the received signal is dechirped by using the obtained phase approximation and the interference is, in turn, suppressed by excising the corrupted low-pass frequency band. For the estimation of polynomial coefficients, we use the product high-order ambiguity function (PHAF), known for its capability to successfully resolve components of a multicomponent polynomial-phase signal (PPS). The proposed method can suppress interferences with both polynomial and non-polynomial phase. In addition, it can suppress both monocomponent and multicomponent interferences. The simulations show that the proposed method outperforms time-frequency (TF) methods, that successfully deal with multicomponent interferences, in terms of the error probability and computational complexity.     

基于FPGA的Kalman滤波器的设计

针对电路设计中经常碰到数据的噪声干扰现象,提出了一种Kalman滤波的FPGA实现方法。该方法采用了Ⅱ公司的高精度模数转换器ADS1251以及Altera公司的EPIC12,首先用卡尔曼滤波算法设计了一个滤波器,然后将该滤波器分解成简单的加、减、乘、除运算。通过基于FPGA平台的硬件与软件的合理设计,成功地实现了数据噪声的滤除设计,并通过实践仿真计算,验证了所实现滤波的有效性。     

宽带数字信道化接收机算法研究与硬件实现

对宽带数字信道化接收机进行了理论研究与硬件实现。该系统模型采用多相滤波结构,使用IFFT算法简化信道化多相滤波器结构与参数,并对各个信道进行下变频产生基带信号以便后续信号识别分析处理,信道化频带划分采用均匀且相邻信道50%交叠的方式。该系统硬件采用A/D转换芯片和FPGA芯片实现,A/D转换芯片完成宽带信号采集,FPGA芯片完成相关算法软件实现。该接收机结构具有设计灵活、实现简单、计算效率高、实时处理能力强、计算量低、FPGA硬件资源少等优点。     

基于AVR单片机的图书录入系统

介绍一种AVR单片机在图书录入系统中的应用,对系统的软件和硬件设计做了说明。本设计以高性能、低功耗的8位AVR微处理器ATmega32L为核心,通过控制步进电机实现执行机构的移动、定位等功能,对书籍进行自动翻页、拍照,适用于有收藏价值、书况不好的书籍的电子图像录入保存。     

Physicochemically Stable Polymer‐Coupled Oxide Dielectrics for Multipurpose Organic Electronic Applications

A chemically coupled polymer layer is introduced onto inorganic oxide dielectrics from a dilute chlorosilane‐terminated polystyrene (PS) solution. As a result of this surface modification, hydrophilic‐oxide dielectrics gain hydrophobic, physicochemically stable properties. On such PS‐coupled SiO₂ or AlO_x dielectrics, various vacuum‐ and solution‐processable organic semiconductors can develop highly ordered crystalline structures that provide higher field‐effect mobilities (μ_FETs) than other surface‐modified systems, and negligible hysteresis in organic field‐effect transistors (OFETs). In particular, the use of PS‐coupled AlO_x nanodielectrics enables a solution‐processable triethylsilylethynyl anthradithiophene OFET to operate with μ_FET ～ 1.26 cm² V^?1 s^?1 at a gate voltage below –1 V. In addition, a complementary metal‐oxide semiconductor‐like organic inverter with a high voltage gain of approximately 32 was successfully fabricated on a PS‐coupled SiO₂ dielectric.     

一种新的点目标无源极化校准方案

极化校准是极化散射矩阵正确获取的重要步骤之一,大口径雷达的极化校准一直是一个难点。为此,提出一种新的无源极化校准方案,该方案利用已校准的小口径雷达来校准大口径雷达。首先,通过外场实验用单个二面角校准小口径雷达;然后,小口径雷达发射信号照射卫星,大小口径两部雷达同时接收并进行信号处理,给出相应的校准算法,最后,通过专业电磁计算软件获得定标体以及卫星散射矩阵的理论值,仿真实验结果验证了提出的极化校准方案的有效性。     

通信用VRLA蓄电池组的可靠性研究

VRLA蓄电池组是当前通信电源系统中主要的储能装置,它的可靠性对通信电源可靠性有着重要影响.文章主要从蓄电池组的接线方式上对蓄电池组的可靠性进行了计算分析,相比先串联后并联方式,先并联后串联方式可有效提高蓄电池组的可靠性.同时,文中还通过冗余设计、正确的使用维护措施来提高蓄电池组的可靠性.     

氨纶涤泡绉的染整工艺探讨

根据氨纶的特性,结合工厂条件对氨纶涤泡绉的退,煮,漂,染,整的基本工艺进行初步探讨,并介绍了氨纶涤泡绉的起绉风格与产品的幅宽加工系数之间的关系。     

Photomultiplication-Type Organic Photodetectors with High EQE-Bandwidth Product by Introducing a Perovskite Quantum Dot Interlayer

A photomultiplication (PM)-type organic photodetector (OPD) that exploits the ionic motion in CsPbI₃ perovskite quantum dots (QDs) is demonstrated. The device uses a QD monolayer as a PM-inducing interlayer and a donor–acceptor bulk heterojunction (BHJ) layer as a photoactive layer. When the device is illuminated, negative ions in the CsPbI₃ QD migrate and accumulate near the interface between the QDs and the electrode; these processes induce hole injection from the electrode and yield the PM phenomenon with an external quantum efficiency (EQE) >2000% at a 3 V applied bias. It is confirmed that the ionic motion of the CsPbI₃ QDs can induce a shift in the work function of the QD/electrode interface and that the dynamics of ionic motion determines the response speed of the device. The PM OPD showed a large EQE-bandwidth product >10⁶ Hz with a −3 dB frequency of 125 kHz at 3 V, which is one of the highest response speeds reported for a PM OPD. The PM-inducing strategy that exploits ionic motion of the interlayer is a potential approach to achieving high-efficiency PM OPDs.