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排序方式: 共有1628条查询结果,搜索用时 15 毫秒
11.
Nathalie M. Malewicz Zahra Rattray Sebastian Oeck Sebastian Jung Vicente Escamilla-Rivera Zeming Chen Xiangjun Tang Jiangbing Zhou Robert H. LaMotte 《International journal of molecular sciences》2022,23(9)
Background: Capsaicin, the hot pepper agent, produces burning followed by desensitization. To treat localized itch or pain with minimal burning, low capsaicin concentrations can be repeatedly applied. We hypothesized that alternatively controlled release of capsaicin from poly(lactic-co-glycolic acid) (PLGA) nanoparticles desensitizes superficially terminating nociceptors, reducing burning. Methods: Capsaicin-loaded PLGA nanoparticles were prepared (single-emulsion solvent evaporation) and characterized (size, morphology, capsaicin loading, encapsulation efficiency, in vitro release profile). Capsaicin-PLGA nanoparticles were applied to murine skin and evaluated in healthy human participants (n = 21) for 4 days under blinded conditions, and itch and nociceptive sensations evoked by mechanical, heat stimuli and pruritogens cowhage, β-alanine, BAM8-22 and histamine were evaluated. Results: Nanoparticles (loading: 58 µg capsaicin/mg) released in vitro 23% capsaicin within the first hour and had complete release at 72 h. In mice, 24 h post-application Capsaicin-PLGA nanoparticles penetrated the dermis and led to decreased nociceptive behavioral responses to heat and mechanical stimulation (desensitization). Application in humans produced a weak to moderate burning, dissipating after 3 h. A loss of heat pain up to 2 weeks was observed. After capsaicin nanoparticles, itch and nociceptive sensations were reduced in response to pruritogens cowhage, β-alanine or BAM8-22, but were normal to histamine. Conclusions: Capsaicin nanoparticles could be useful in reducing pain and itch associated with pruritic diseases that are histamine-independent. 相似文献
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14.
Yixuan Jia Christoph A. Spiegel Alexander Welle Stefan Heißler Elaheh Sedghamiz Modan Liu Wolfgang Wenzel Maximilian Hackner Joachim P. Spatz Manuel Tsotsalas Eva Blasco 《Advanced functional materials》2023,33(39):2207826
Manufacturing programmable materials, whose mechanical properties can be adapted on demand, is highly desired for their application in areas ranging from robotics, to biomedicine, or microfluidics. Herein, the inclusion of dynamic and living bonds, such as alkoxyamines, in a printable formulation suitable for two-photon 3D laser printing is exploited. On one hand, taking advantage of the dynamic covalent character of alkoxyamines, the nitroxide exchange reaction is investigated. As a consequence, a reduction of the Young´s Modulus by 50%, is measured by nanoindentation. On the other hand, due to its “living” characteristic, the chain extension becomes possible via nitroxide mediated polymerization. In particular, living nitroxide mediated polymerization of styrene results not only in a dramatic increase of the volume (≈8 times) of the 3D printed microstructure but also an increase of the Young's Modulus by two orders of magnitude (from 14 MPa to 2.7 GPa), while maintaining the shape including fine structural details. Thus, the approach introduces a new dimension by enabling to create microstructures with dynamically tunable size and mechanical properties. 相似文献
15.
J. A. Jimenez-Tejada J. A. Lopez-Villanueva P. Cartujo J. Vicente J. E. Carceller 《Journal of Electronic Materials》1992,21(9):883-886
The energy levels introduced by Pt in silicon have been measured in a non-abruptp
+-n junction using constant-capacitance thermal-emission rate measurements and a numerical simulation of high frequency-capacitance.
Two levels have been detected with activation energies of:E
c -E
T = 0.22 eV with acceptor character andE
T -E
v = 0.34 eV with donor character. The sample preparation and diffusion of Pt is similar to previous works in which an acceptor
levelE
c -E
T = 0.34 eV was found instead of or besides a donorlike levelE
T -E
v = 0.34 eV. Our numerical calculation of the shallow-impurity profile points to the existence of a gradual transition near
the metallurgical junction for these samples. We have demonstrated that the well-known model of an abrupt junction is not
appropriate for these types of junctions, and could lead to errors in the location attributed to the detected levels. Simulation
of the electrical behavior leads to the non-existence of the acceptor levelE
c −E
T = 0.34 eV located in then-side of the junction. 相似文献
16.
Richard Perez Robert Seals Ronald Stewart Antoine Zelenka Vicente Estrada-Cajigal 《Solar Energy》1994,53(6):491-495
In this paper, the question of satellite-derived irradiance is addressed on two levels. First, the question of physical accuracy is addressed by comparing satellite-predicted hourly/daily global and direct irradiance with controlled ground measurements in climatically distinct environments. This accuracy is compared to the error made as a function of distance when extrapolating the needed data from the closest ground measurement site. Second, the question of end-use accuracy is addressed by comparing satellite-derived, photovoltaic-utility load-match benchmarks with actual benchmarks for three US electric utilities where ground measurements were available. 相似文献
17.
The European Space Agency's Deep-Space Antennas 总被引:1,自引:0,他引:1
Vassallo E. Martin R. Madde R. Lanucara M. Besso P. Droll P. Galtie G. De Vicente J. 《Proceedings of the IEEE. Institute of Electrical and Electronics Engineers》2007,95(11):2111-2131
The European Space Agency (ESA) is today autonomously flying three interplanetary missions: Rosetta traveling to the comet Churyumov-Gerasimenko and the two orbiters Mars Express and Venus Express. The capability of supporting these and future deep-space missions is the consequence of a farsighted decision taken in 1996 to expand the ESA network of 15-m tracking antennas into the deep-space domain. The ambitious plan to provide around-the-clock coverage to all ESA interplanetary missions is almost completed: two deep-space antennas, located in New Norcia (Australia) and Cebreros (Spain), have been in operation since 2002 and 2005, respectively, while a third antenna is planned for 2011. This paper presents the two existing antennas starting from the underlying system requirements originated from the Rosetta mission, which was the most demanding in terms of required performance. The selected architecture is then described, followed by a detailed discussion about the critical performances that play a major role in deep-space support and the associated design issues. 相似文献
18.
Analysis and characterization of the hyperchaos generated by a semiconductor laser subject to a delayed feedback loop 总被引:5,自引:0,他引:5
We characterize the chaotic dynamics of semiconductor lasers subject to either optical or electrooptical feedback modeled by Lang-Kobayashi and Ikeda equations, respectively. This characterization is relevant for secure optical communications based on chaos encryption. In particular, for each system we compute as a function of tunable parameters the Lyapunov spectrum, Kaplan-Yorke dimension and Kolmogorov-Sinai entropy. 相似文献
19.
José Vicente Calvano Antônio Carneiro de Mesquita Filho Vladimir Castro Alves Marcelo Soares Lubaszewski 《Microelectronics Journal》2002,33(10):823-834
This work presents a method for synthesizing testable continuous-time linear time-invariant electrical networks using 1st order blocks for the implementation of analog linear circuits. A functional-structural fault model for the block, and a fault dictionary are proposed together with a simple set of test vectors. The method allows, also, the fault grade evaluation for the modeled faults. The results obtained from the two application examples have shown the suitability of the approach as a design for test method for analog circuits. 相似文献
20.
L. Quintanilla J. Arias L. Enríquez J. Vicente J. Barbolla D. Vázquez A. Rueda 《Analog Integrated Circuits and Signal Processing》2003,34(3):201-209
A fully differential SC bandpass filter (central frequency, 58 kHz; Q = 15; and voltage gain, 8) based on the switched-opamp approach is designed and implemented in this work. The filter operates from a single 1 V supply voltage and is realized in a 0.35 m CMOS technology. It has been characterized with a sampling frequency of 1 MHz and its power consumption is about 230 W. As a main internal filter component, an appropiate switched opamp was also designed. Its common-mode feedback circuit was implemented by using an error amplifier and sampling of the output common-mode voltage is carried out by applying a DC offset to level shift the common-mode sample. It provides an accurate common-mode output for a wide temperature and supply voltage ranges. 相似文献