Determination of REE,U,Th,Ba,and Zr in simulated hydrogeological leachates by ICP-AES after matrix solvent extraction

A fast, reliable and precise method for the determination of Ba, Zr, Th, U, La, Ce, Eu, Hf and Gd in leaching solutions containing up to 1 mol/L FeCl3 by inductively coupled plasma-atomic emission spectrometry (ICP-AES) was described. Liquid-liquid extraction with diethyl ether was applied for selective and quantitative extraction of the iron with a decontamination factor of 65000. The study has enabled the determination of rare earth elements, U, Th Ba, and Zr, from the solution with high iron content with detection limits in the range of 1-24 ng/ml and a precision of 0.9%-4.6 % relative standard deviation. The developed method was simple and was adopted for implementation in a glove box for handling radioactive materials.     

Catalytic effect of the Cu(II)‐ and Fe(III)‐cyclo‐hexanebutyrates on olive oil oxidation measured by Rancimat

In this work the Rancimat technique (temperature 110 °C and air flow 20 l/h) was used in order to test the catalytic effect induced by Cu(II)‐and Fe(III)‐ions on olive oil oxidation. Different amounts of Cu(II)‐ and Fe(III)‐cyclohexanebutyrates were added to a refined olive oil. Copper was shown to be a more active catalyst than iron. In fact, the induction time of the oil was halved by the addition of about 120 ng/g of copper versus 9000 ng/g of iron. The effect of copper and iron was also evaluated on the oil enriched with increasing quantities of caffeic acid (50, 100 and 200 mg/kg). The addition of this phenol induced a significant protective effect which delayed the oxidation of both the control and the oil samples enriched with metals. However, copper‐catalyzed oxidation also in the presence of the antioxidant, thus decreasing the oil oxidative stability approximately three times compared to the control.     

Numerical discretization of stationary random processes

The increasing interest of the research community to the probabilistic analysis concerning the civil structures with space-variant properties points out the problem of achieving a reliable discretization of random processes (or random fields in a multi-dimensional domain). Given a discretization method, a continuous random process is approximated by a finite set of random variables. Its dimension affects significantly the accuracy of the approximation, in terms of the relevant properties of the continuous random process under investigation. The paper presents a discretization procedure based on the truncated Karhunen–Loève series expansion and the finite element method. The objective is to link in a rational way the number of random variables involved in the approximation to a quantitative measure of the discretization accuracy. The finite element method is applied to evaluate the terms of the series expansion when a closed form expression is not available. An iterative refinement of the finite element mesh is proposed in this paper, leading to an accurate random process discretization. The technique is tested with respect to the exponential covariance function, that enables a comparison with analytical expressions of the approximated properties of the random process. Then, the procedure is applied to the square exponential covariance functions, which is one of the most used covariance models in the structural engineering field. The comparison of the adaptive refinement of the discretization with a non-adaptive procedure and with the wavelet Galerkin approach allows to demonstrate the computational efficiency of the proposal within the framework of the Karhunen–Loève series expansion. A comparison with the Expansion Optimal Linear Estimation (EOLE) method is performed in terms of efficiency of the discretization strategy.     

Hybrid composite scaffolds prepared by sol–gel method for bone regeneration

This study reports the synthesis and characterization of hydroxyapatite (HA)/polycaprolactone (PCL) hybrid composite materials synthesized by sol–gel method. The fabrication of scaffolds was performed by salt-leaching technique using NaCl as porogen agent. In the first step, the physico-chemical characterization of composite material was performed to evaluate the composition and the interaction between the organic/inorganic phases. In the second step, optimized scaffolds were bioactivated on the surface. The combined effect of scaffold morphology and surface bioactivity is ideal for bone tissue engineering, supporting bone cells adhesion, proliferation and differentiation. Here, a combined strategy involving biomimetic approach, using a supersaturated Simulated Body Fluid (SBF), and salt-leaching technique has been developed to grow hydroxyapatite in composite scaffolds able to regenerate the natural bone.     

Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance

Notch signaling dysregulation encourages breast cancer progression through different mechanisms such as stem cell maintenance, cell proliferation and migration/invasion. Furthermore, Notch is a crucial driver regulating juxtracrine and paracrine communications between tumor and stroma. The complex interplay between the abnormal Notch pathway orchestrating the activation of other signals and cellular heterogeneity contribute towards remodeling of the tumor microenvironment. These changes, together with tumor evolution and treatment pressure, drive breast cancer drug resistance. Preclinical studies have shown that targeting the Notch pathway can prevent or reverse resistance, reducing or eliminating breast cancer stem cells. In the present review, we will summarize the current scientific evidence that highlights the involvement of Notch activation within the breast tumor microenvironment, angiogenesis, extracellular matrix remodeling, and tumor/stroma/immune system interplay and its involvement in mechanisms of therapy resistance.     

Cytidine 5′-Diphosphocholine (Citicoline) in Glaucoma: Rationale of Its Use,Current Evidence and Future Perspectives

Cytidine 5′-diphosphocholine or citicoline is an endogenous compound that acts in the biosynthetic pathway of phospholipids of cell membranes, particularly phosphatidylcholine, and it is able to increase neurotrasmitters levels in the central nervous system. Citicoline has shown positive effects in Parkinson’s disease and Alzheimer’s disease, as well as in amblyopia. Glaucoma is a neurodegenerative disease currently considered a disease involving ocular and visual brain structures. Neuroprotection has been proposed as a valid therapeutic option for those patients progressing despite a well-controlled intraocular pressure, the main risk factor for the progression of the disease. The aim of this review is to critically summarize the current evidence about the effect of citicoline in glaucoma.     

Agronomic performance of experimental fertilizers on spinach (<Emphasis Type="Italic">Spinacia oleracea</Emphasis> L.) in organic farming

In organic farming, soil application of processed agro-industrial by-products could sustain soil fertility for vegetables, which have short cropping cycles. Therefore, the objectives of this 2-year research on organic spinach crop were to assess the productive performance of different experimental fertilizers, the effects on soil fertility, and investigate the dynamics of some soil properties and the N balance. Two types of olive pomace mixtures, with a different initial C/N ratio, were composted and both stopped at the active phase (A1 and B1) and processed until maturation (A2 and B2). Also an anaerobic digestate (DA), and the B2 applied as amendment (B2A) were studied. The four composts, DA, and B2A were compared with a commercial organic fertilizer (Org), and a control (N0). The Org resulted as not sustainable in maintaining soil fertility in the long-term, mainly due to reduction in the soil of total organic carbon by 32 %, compared to the average of the other treatments. Conversely, choosing stage of maturity and adequate C/N of starting mixtures was among the best practices for compost use in spinach crop. The great content of nutrients (N and K higher by 102 and 86 % than Org, respectively), and N surplus (1431 kg ha^?1) in the B2A plots would suggest that they could accumulate after subsequent soil applications, with the risk of losses in the environment. The DA appeared to be the most suitable fertilizer to get a favorable trade-off among yield, quality and N-use efficiency, when applied according to best agronomic practices.     

Mooreamide A: A Cannabinomimetic Lipid from the Marine Cyanobacterium Moorea bouillonii

Bioassay‐guided fractionation of a collection of Moorea bouillonii from Papua New Guinea led to the isolation of a new alkyl amide, mooreamide A ( 1 ), along with the cytotoxic apratoxins A–C and E. The planar structure of 1 was elucidated by NMR spectroscopy and mass spectrometry analysis. Structural homology between mooreamide A and the endogenous cannabinoid ligands, anandamide, and 2‐arachidonoyl glycerol inspired its evaluation against the neuroreceptors CB₁ and CB₂. Mooreamide A was found to possess relatively potent and selective ligand binding activity to CB₁ (K₁ = 0.47 µM) versus CB₂ (K₁ > 25 µM). This represents the most potent marine‐derived CB₁ ligand described to date and adds to the growing family of marine metabolites that exhibit cannabinomimetic activity.