Performance effects of innovative IT applications over time

There is evidence to indicate that the effects of new product and service innovations change over time as a result of learning and competition. However, there have not been any studies of the effects of learning and competition on the impacts of innovative information technology (IT) applications. This paper presents the results of an extensive study of the effects of very early investments in automated teller machines (ATMs) by banks, on market share and overall bank performance. The study spans the period from 1971 to 1984 and includes 2534 banks from across the United States. The results indicate that the impacts of early ATM investments can best be described by exponential and logistic models, indicating that the benefits were very small at first, but increased rapidly after a few years. In addition, the benefits obtained by the earliest adopters were larger than those obtained by the banks that adopted later. These results have important implications for IT investment decisions. The results also suggest that cross-sectional studies, conducted soon after an application is installed, may fail to find benefits even if large benefits are obtained     

Chronic headaches and sleep disorders

BACKGROUND: Headaches and sleep problems are common complaints in the daily practice of the general practitioner. Since the relationship between headaches and sleep complaints is complex, clear models of interaction are needed for adequate diagnosis and treatment. METHODS: All subjects, successively seen in a headache clinic during a defined period, were subdivided based on the time of onset of cephalalgia. Subjects who reported onset of headache on a long-term basis, during the nocturnal or early morning (before final awakening) period, were systematically studied by a headache clinic and a sleep disorders center. This subgroup represented 17% of the total headache group. RESULTS: Although the results of the headache clinic study did not differentiate this subgroup from the other patients, the sleep disorders center's interviews and questionnaires demonstrated a significant impact of the sleep disorders on headache and daytime function. Nocturnal monitoring during sleep identified specific sleep disorders in 55% of the subjects with onset of headache during the nocturnal sleep period. Follow-up after treatment of the sleep disorder showed that all subjects with an identifiable sleep disorder reported either an improvement or absence of their headache. The subjects identified with periodic limb movement syndrome were mostly those who reported only an improvement in their sleep and still needed treatment for their headaches. The question of the interaction and association of sleep-related headache and periodic limb movement syndrome is unresolved. CONCLUSION: Headaches occurring during the night or early morning are often related to a sleep disturbance.     

The minimum dosage of praziquantel in the treatment of Taenia saginata, 1986-1993

Patients who have a unicornuate uterus with a noncommunicating rudimentary horn that contains an endometrial cavity are at risk for endometriosis and obstetric complications. As in this case, resection of the rudimentary horn can be performed laparoscopically without increased risk to the patient and with some potential benefit.     

Blocage par injection de modes sous- harmoniques d’un oscillateur utilisant une ligne à retard à ondes de surface

A nonlinear regeneration pulsed oscillator driven by a monochromatic source has been built. Subharmonics of the resonance carrier/modulation are measured with an accuracy of 10^-10 thanks to the use of a double beats measurement set-up. The multiscale analysis of frequency readings reveals a rich fine structure which is in agreement with the nonlinear topological approach of synchronized states.     

Differential acetylcholine and GABA release from cultured chick retina cells

In the present work we investigated the mechanisms controlling the release of acetylcholine (ACh) and of gamma-aminobutyric acid (GABA) from cultures of amacrine-like neurons, containing a subpopulation of cells which are simultaneously GABAergic and cholinergic. We found that 81.2 +/- 2.8% of the cells present in the culture were stained immunocytochemically with an antibody against choline acetyltransferase, and 38.5 +/- 4.8% of the cells were stained with an antibody against GABA. Most of the cells containing GABA (87.0 +/- 2.9%) were cholinergic. The release of acetylcholine and GABA was mostly Ca2+-dependent, although a significant release of [3H]GABA occurred by reversal of its transporter. Potassium evoked the Ca2+-dependent release of [3H]GABA and [3H]acetylcholine, with EC50 of 31.0 +/- 1.0 mm and 21.6 +/- 1.1 mm, respectively. The Ca2+-dependent release of [3H]acetylcholine was significantly inhibited by 1 micrometer tetrodotoxin and by low (30 nm) omega-conotoxin GVIA (omega-CgTx GVIA) concentrations, or by high (300 nm) nitrendipine (Nit) concentrations. On the contrary, the release of [14C]GABA was reduced by 30 nm nitrendipine, or by 500 nm omega-CgTx GVIA, but not by this toxin at 30 nm. The release of either transmitters was unaffected by 200 nm omega-Agatoxin IVA (omega-Aga IVA), a toxin that blocks P/Q-type voltage-sensitive Ca2+ channels (VSCC). The results show that Ca2+-influx through omega-CgTx GVIA-sensitive N-type VSCC and through Nit-sensitive L-type VSCC induce the release of ACh and GABA. However, the significant differences observed regarding the Ca2+ channels involved in the release of each neurotransmitter suggest that in amacrine-like neurons containing simultaneously GABA and acetylcholine the two neurotransmitters may be released in distinct regions of the cells, endowed with different populations of VSCC.     

Automatic verification of concurrent stochastic systems

Formal Methods in System Design - Automated verification techniques for stochastic games allow formal reasoning about systems that feature competitive or collaborative behaviour among rational...     

Word sense disambiguation for spam filtering

Spam has become a major issue in computer security because it is a channel for threats such as computer viruses, worms, and phishing. More than 86% of received e-mails are spam. Historical approaches to combating these messages, including simple techniques such as sender blacklisting or the use of e-mail signatures, are no longer completely reliable. Many current solutions feature machine-learning algorithms trained using statistical representations of the terms that most commonly appear in such e-mails. However, these methods are merely syntactic and are unable to account for the underlying semantics of terms within messages. In this paper, we explore the use of semantics in spam filtering by introducing a pre-processing step of Word Sense Disambiguation (WSD). Based upon this disambiguated representation, we apply several well-known machine-learning models and show that the proposed method can detect the internal semantics of spam messages.     

Resistivity as a function of composition in the superconducting Nb-Pt A15 phase

The electrical resistivity of the A15 compound Nb_100–x Pt _x (20x28.9) is measured as a function of compositionx from room temperature to the superconducting transition temperatureT _c The residual resistivity ₀ is observed to be nearly independent of composition on the Nb-rich side of stoichiometry, but strongly dependent on the Pt-rich side. A closeT _c correlation with the resistivity sloped/dT at high temperatures and with the electronic specific heat coefficient , which are proportional to the superconducting coupling parameter , is noted. The results can be understood in terms of an order-disorder model.