Transmutation missions for fusion neutron sources

There are a number of potential neutron transmutation missions (destruction of long-lived radioisotopes in spent nuclear fuel, ‘disposal’ of surplus weapons-grade plutonium, ‘breeding’ of fissile nuclear fuel) that perhaps best can be performed in sub-critical nuclear reactors driven by a neutron source. The requirements on a tokamak fusion neutron source for such transmutation missions are significantly less demanding than for commercial electrical power production. A tokamak fusion neutron source based on the current physics and technology database (ITER design base) would meet the needs of the spent nuclear fuel transmutation mission; the technical issue would be achieving ≥50% availability, which would require advances in component reliability and in steady-state physics operation.     

Approximability Properties for Second-Order Sliding Mode Control Systems

New definitions of approximability are presented for nonlinear second-order sliding mode control systems. Such robustness properties are compared with those already known for first-order methods. Sufficient conditions are obtained for second-order regularization, a sliding error estimate is derived, and some relevant examples are discussed.     

Subcellular localization of Bcl-2 protein in synovial sarcoma

The subcellular localization of Bcl-2 protein in surgically resected, fixed-frozen tissue specimens of seven tumors from six cases of synovial sarcoma and a synovial sarcoma cell line was examined using laser-scanning confocal microscopy and immunoelectron microscopy. Bcl-2 protein in synovial sarcoma cells was detected in the nuclear envelope, endoplasmic reticulum membrane, and mitochondrial circumference. Based on the finding of pre-embedding immunoelectron-microscopy observation, the distribution of Bcl-2 protein in such membranous organella was patchy. A computer-based image analysis failed to reveal any quantitative differences between the inner and the outer mitochondrial membranes. The tumorigenesis of synovial sarcoma is also discussed from the viewpoint of Bcl-2 overexpression.     

Detection of human papillomavirus gene sequences in laryngeal tumors and premalignant changes by polymerase chain reaction

Human papillomavirus gene sequences have been detected in a number of malignant and benign tumours. Non-oncogenic types 6 and 11 are etiological factors of benign mucosal tumours. Types 16 and 18 can be detected in malignancies most often but their role in the etiopathogenesis of cancers is still unclear. In our study we examined formalin-fixed and paraffin-embedded archive laryngeal tissues containing squamous cell carcinoma, papilloma and precancerous lesions for the presence of human papillomavirus genes. As a control we also examined tissues harbouring laryngeal nodules which represented the normal larynx in our study. After DNA preparation from the paraffin blocks we performed polymerase chain reaction to detect the DNA of human papillomavirus types 6, 11, 16 and 18. In the squamous cell carcinomas, papillomas and precancerous lesions the presence of human papillomavirus gene sequences was significantly higher than in the control group. To verify the integrity of DNA we also amplified a sequence deriving from the cellular beta-globin gene. Based on the 100% positivity for this gene we declare that the combination of our DNA preparation and polymerase chain reaction is a reliable method for detecting DNA sequences from formalin-fixed and paraffin-embedded tissues.     

Molecular analysis of p21 and p27 genes in human pituitary adenomas

OBJECTIVES: To determine the prevalence of thyroid dysfunction in institutionalised elderly people in Cape Town and to assess the usefulness of an abnormal thyroid-stimulating hormone (TSH) concentration as a screening test in this group. DESIGN: Cross-sectional survey. SETTING: Four old-age homes in Cape Town. SUBJECTS: Old-age home residents aged 60 years and over. OUTCOME MEASURES: Serum concentrations of TSH, free thyroxine and free tri-iodothyronine. RESULTS: Serum TSH estimations were performed on 658 participants, and were abnormal in 103 (15.6%)-41 (6.2%) being elevated (> 5.0 microU/ml) and 62 (9.4%) being low (> 0.4 microU/ml). There were 3 newly diagnosed cases of hyperthyroidism and 7 of hypothyroidism. Subclinical disease was diagnosed in 40 subjects. The overall prevalence of thyroid dysfunction in this population was 11.2%. In 22 (3.4%) this had previously been recognised, while in 50 (7.8%) the dysfunction was newly diagnosed by the current survey. The positive predictive value of a TSH concentration > 20 microU/ml in predicting hypothyroidism is 67%, while it will predict 100% of cases of subclinical hypothyroidism. A TSH concentration < 0.1 microU/ml will predict 23% of cases of hyperthyroidism, but 81% of cases of subclinical disease. CONCLUSIONS: The prevalence of thyroid dysfunction in institutionalised elderly people in Cape Town is similar to that reported for elderly people in other centres. Thyroid dysfunction had not previously been recognised in approximately two-thirds of the subjects in this study. The serum TSH concentration is a reliable screening test for thyroid dysfunction in the elderly, but is less useful if used to identify biochemical thyroid disease. An elevated TSH concentration is a better predictor of thyroid dysfunction in the elderly than a depressed TSH concentration.     

A packet delay analysis for cellular digital packet data

We formulate and analyze a model of voice and data burst traffic for cellular digital packet data (CDPD). To develop a tractible model, we make some reasonable simplifying assumptions to model the voice traffic and one of the logical CDPD channels as an M/M/1 queue in a random environment. Rather than explicitly solve the resulting matrix quadratic equation, we develop an asymptotic analysis that gives us simple approximate formulas (with error bounds) for many performance measures of interest. In particular, one metric that we highlight comes from using our approximate mean data burst delay formula to characterize the performance of a set of interacting logical CDPD channels. We do so by describing it in terms of an equivalent number of independent, dedicated CDPD channels, We can use this metric to suggest what the optimal number of logical CDPD channels for a given system should be     

Optical fiber vibration sensor using (Pancharatnam) phase stepinterferometry

A fiber-optic vibration sensor based on polarization and phase-step interferometry is reported. Left- and right-circularly polarized light coming back from the reference and signal arms of a modified Michelson fiber interferometer is processed with an array of five linear analyzers separated angular steps of π/4 (rad) from each other. Thus, five interference patterns are acquired simultaneously and the dynamical phase retrieval problem is reduced to five-step interferometry in the time-domain. A vibration sensor as described above was built by the authors and its performance was investigated     

Experimental determination of electron and hole mobilities in MOSaccumulation layers

This letter presents for the first time, the experimentally determined majority carrier mobilities in the accumulation layer of a MOSFET for both p-type and n-type channel doping for a wide range of doping concentrations. The measured carrier mobility is observed to follow a universal behavior at high transverse fields, similar to that observed for minority carriers in MOS inversion layers. At the higher doping levels, the effective mobility for majority carriers at low to moderate transverse fields is found to be very close to the bulk mobility. This is believed to be due to carrier screening of the ionized impurity scattering which dominates at the higher doping concentrations