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21.
Salinger Walter L.; Ladrow Pamela; Wheeler Catherine 《Canadian Metallurgical Quarterly》2003,117(6):1257
Reeler (rl/rl) and reeler/wild-type (+/rl) mice synthesize Reln at subnormal rates, as do patients with schizophrenia, bipolar disorder, and autism, thereby forming the basis for a Reln hypothesis for vulnerability to these psychopathologies and justifying attention to the behavioral phenotypes of Reln-deficient mice. Tests of gait, emotionality, social aggression, spatial working memory, novel-object detection, fear conditioning, and sensorimotor reflex modulation revealed the behavioral phenotype of rl/rl, but not +/rl, mice to be different from that of wild-type (+/+) mice. These results reveal no effect of Reln gene dosage and provide significant challenges to both the Reln and the neurodevelopmental hypotheses of the etiology of major psychopathologies. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
22.
Walter Savassi Eddie Mancini 《The Structural Design of Tall and Special Buildings》2004,13(4):315-333
In a previous paper (Mancini and Savassi, 1999), it was shown that every plane panel, used to brace tall building structures, can be easily and generally approached through the use of the continuous medium technique (CMT) (Albigés and Goulet, 1960). In that paper, following a so‐called local formulation, i.e., by deriving the governing differential equations system of the panel, in terms of u(z) panel horizontal displacement and wi columns or walls axial displacements, the equivalence (likeness) of formal mathematics, and hence of structural behaviour, between the panel composed by a pair of shear walls associated by lintel beams and another panel formed by the plane association, by pinned horizontal bars, of one shear wall and one single bay frame, was also shown. In both cases, axial deformations due to axial forces on vertical members were taken into account. In this paper, confirming those conclusions, but now following a global formulation (i.e., considering the total potential energy of each panel: strain energy plus applied load potentials), the mathematical equivalence between those two types of plane panels is again revealed by comparison of their two total potential energy analytical expressions. Additionally, based on that variational approach, the one‐dimensional finite element formulation is presented. This enlarges the possibilities of solutions for more general types of panels, like those with variable geometry or loading, without any further difficulty. The procedure, for any type of panel, can be codified in one single computer program, very similar to those used to solve plain continuous beam problems. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
23.
Dr. Jana Buchwalter Prof. Dr. Walter Brenner Dr. Rüdiger Zarnekow 《WIRTSCHAFTSINFORMATIK》2002,44(4):345-353
Many companies and purchasing departments only possess a limited knowledge about the modelling of inter-company business processes for electronic procurement. In the past the discussion about electronic procurement was mostly focused on technical aspects. This article introduces a reference process model for procurement auctions. The process model is made up of a basic process, which describes a minimal process for procurement auctions, and a number of process alternatives, which allow for the adoption of the basic process to changing parameters and individual company requirements. 相似文献
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LW Didenko IB Buchwalow W Schulze K Augsten M Susa E Unger 《Canadian Metallurgical Quarterly》1996,98(4):399-409
Heterotrimeric GTP-binding proteins (G-proteins) have been shown to play an important role in cellular signalling. However, G-protein involvement in the intracellular spreading of bacterial pathogens is still poorly understood. In this study, antibodies, that recognize G-protein alpha-subunits (anti-G alpha), were used to investigate the localization of G-proteins in the macrophage-like cell line P388D1 and E. coli, also in their L-forms, during phagocytosis. In E. coli, anti-G alpha-binding sites were detected preferably in the cell wall and septa of the whole bacterial forms as well as in the cytoplasm of L-forms. Western blotting of bacterial lysates demonstrated protein bands with positive immunoreaction to antibodies against Gs alpha, Gi alpha, and Gcommon alpha with a higher affinity to the antibody against Gs alpha. Immunoreaction with the anti-Gs alpha-antibody was markedly higher in pathogenic strains of E. coli. Because of the conserved structure in all GTP-binding proteins which seem to derive from a single primordial protein involved in signal transduction mechanisms, it is reasonable to assume that some anti-Ga-positive proteins in E. coli might be related to G-proteins of higher organisms. A putative candidate for bacterial G-proteins seems to be a 36 kDa protein. Enhancement in G-protein immunostaining in the cytoplasm of macrophages around the internalized bacteria testifies to the involvement of G-proteins in mediation of endocytosis responses of phagocytes. 相似文献
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We have used proteolysis to examine the environment through which nascent secretory proteins are translocated across the membrane of the endoplasmic reticulum. After solubilization of rough microsomes with detergent, fragments comprised of the approximately 70 carboxyl-terminal amino acids of translocating nascent chains initiated and targeted in vivo were protected from digestion by added proteases. About 40 amino acids of nascent chains were protected from proteolysis by the ribosome; thus, membrane-derived components protect an additional 30 amino acids. Under conditions in which those 30 additional amino acids are protected, only a small set of integral membrane proteins remained associated with the ribosome. These proteins include the Sec61 complex previously identified as the core component of the membrane-bound protein translocation apparatus. These results support the concept of a translocation pore that makes intimate contact with the ribosome and thereby protects nascent chains from proteolytic digestion for an additional, constant length. 相似文献
28.
29.
Structure-activity studies of human tumour necrosis factors 总被引:3,自引:0,他引:3
Van Ostade Xaveer; Tavernier Jan; Fiers Walter 《Protein engineering, design & selection : PEDS》1994,7(1):5-12
The mechanism by which tumour necrosis factors (TNF and lymphotoxin,also called TNFß and TNFß respectively) exerttheir cytotoxic activity on many malignant cells, remains largelyunknown. Furthermore, the broad array of differentiation (geneinduction) and mitogenic activities towards many primary cellsis still a subject of intensive investigation. TNF is an importantmediator in inflammation, immune responses and infection-relatedphenomena and these activities contribute to the severe toxidtyseen when TNF is used as an anticancer agent. The first stepin the mechanism of action is the specific binding of the ligandto its receptors and dissection of the molecular mechanism involvedin this interaction is the subject of this review. The reasonsfor the interest in this aspect are obvious: first, the developmentof strong antagonistic TNF analogues can be useful in dampeningthe potentially lethal or debilitating effects of an overproductionof the cytokine (as in septic shock or rheumatoid arthritis).Secondly, since two distinct TNF receptors exist, constructionof TNF muteins that distinguish between both types may leadto derivatives of this plekrtropic agent with a more restrictedbiological activity pattern. Ideally, one would like to developa TNF mutant that has retained its cytotoxic action on tumourcells without inducing the deleterious systemic toxteity. Suchan optimized TNF molecule could become a potent anticancer agent 相似文献
30.
H.-U. Waiblinger N. Graf D. Mäde K. Woll U. Busch B. Holland H. Pilsl G. Naeumann R. Reiting B. Ehrentreich M. Schulze B. Tschirdewahn C. Brünen-Nieweler G. Hempel M. Weidner A. R. Winterstein 《Journal für Verbraucherschutz und Lebensmittelsicherheit》2007,2(2):126-129
In case of findings of authorized genetically modified (gm) plant ingredients below the 0.9 per cent threshold, exceptions
from labelling requirements according to regulation (EC) No. 1829/2003 can only be made, “provided that this presence is adventitious
or technically unavoidable”. The authors describe factors that should be considered regarding contaminations by gm plant ingredients
as technically unavoidable or not. A practical approach for interpretation, taking into account quality control measures and
documentation as well as present findings in comparable products is proposed.
Received: February 23, 2007 相似文献