Activation of Nrf2/HO-1 by Peptide YD1 Attenuates Inflammatory Symptoms through Suppression of TLR4/MYyD88/NF-κB Signaling Cascade

In this study, we investigate the immunomodulatory effects of a novel antimicrobial peptide, YD1, isolated from Kimchi, in both in vitro and in vivo models. We establish that YD1 exerts its anti-inflammatory effects via up-regulation of the Nrf2 pathway, resulting in the production of HO-1, which suppresses activation of the NF-κB pathway, including the subsequent proinflammatory cytokines IL-1β, IL-6, and TNF-α. We also found that YD1 robustly suppresses nitric oxide (NO) and prostaglandin E2 (PGE₂) production by down-regulating the expression of the upstream genes, iNOS and COX-2, acting as a strong antioxidant. Collectively, YD1 exhibits vigorous anti-inflammatory and antioxidant activity, presenting it as an interesting potential therapeutic agent.     

Facile Fabrication of Povidone Iodine-Embedded Polytetrafluoroethylene Superhydrophobic Films with Improved Antiadhesive and Bactericidal Properties in Bacterial Environments

It remains a challenge to maintain the antiadhesion properties of superhydrophobic films after exposure to bacterial environments. In this work, superhydrophobic bactericidal polymer films via the simple incorporation of polyvinylpyrrolidone-iodine (PVP-I) or iodine into polytetrafluoroethylene (PTFE) are fabricated to improve their antiadhesive and antibacterial capability. Superhydrophobic iodine-embedded films, polytetrafluoroethylene/polyvinylpyrrolidone-iodine and polytetrafluoroethylene-iodine (PTFE/PVP-I and PTFE-I), show excellent antiadhesive and bactericidal performances even post exposure to bacterial solutions as compared to iodine-free counterparts by controlling the release of iodine. Especially, superhydrophobic PTFE/PVP-I films display a more sustained iodine release profile and significant antibacterial properties against gram-positive (S. aureus, methicillin-resistant S. aureus (MRSA)) and gram-negative (E. coli) bacteria. Such a facile combination of antiseptic agents and superhydrophobic surface could be widely used for antiseptic biomedical applications.     

耐腐蚀高压柱塞泵用新型双相不锈钢的研究

叙述了新型双相不锈钢－ＷＳＤ钢的组织及其耐蚀性能。试验结果表明，ＷＳＤ钢在氯化物介显示出优异耐蚀性能，其抗点蚀性能远超过Ｃｒ１３，１８－８Ｔｉ，３１６Ｌ等钢种，达到国外Ａｌ－６Ｘ，ＳＡＦ２２０５等钢种的水平。     

纳米Ti（CN）基金属陶瓷烧结过程中的结构和相变

用分段真空烧结、X射线衍射和背散射扫描电镜研究了纳米Ti（CN）基金属陶瓷在烧结过程中的结构和相成分的演变。结果表明：纳米Ti（CN）基金属陶瓷在900℃以后，Mo2C和TaC开始由于扩散，与Ti（CN）发生固溶反应，在1200℃以前，Mo2C和TaC固溶反应结束，两相均消失。WC在1100℃以后，开始由于扩散，与Ti（CN）发生固溶反应，在1250℃以前消失。在1250℃以后，合金中只有Ti（CN）和Ni（Ni＋Co）两相存在。纳米Ti（CN）粉末与M（M=Mo，W．Ta）反应形成富M的（Ti，M）（CN）固溶体为核，贫M的（Ti，M）（CN）固溶体为环的“亮芯黑环”环形结构，在1350℃即可获得致密的合金。     

关于南京钢铁厂高炉长寿途径的浅见

针对南京钢铁厂高炉寿命较短的现状及国内外长寿高炉的经验，提出南钢高炉在改善原燃料条件下，提高高炉操作水平，改进炉体各部的设计，提高施工质量，加强日常维修，以达到高炉长寿的建议。     

Nd：NaR（WO4）2晶体光谱性能研究（R=Bi，Y）

采用提拉法生长出了掺钕钨酸铋钠（分子式Nd：NaBi（WO4）2，简称Nd：NBW）和掺钕钨酸钇钠（分子式Nd：NaY（WO4）2，简称Nd：NYW）晶体。通过TG-DTA分析得到Nd：NBW的熔点为936．2℃，Nd：NYW的熔点为1209．07℃。由吸收光谱可以看出，Nd：NBW在802nm有较强的吸收峰，Nd：NYW在804nm，752nm，586nm附近有较强、较宽的吸收峰，二者均适合于LD泵浦；并计算了晶体中Nd^＋3＋的吸收截面积。通过比较Nd：NBW和Nd：NYW的红外光谱和拉曼光谱结果，认为二者结构基本相同，为四方晶系、白钨矿结构、141/a空间群。     

Monel400与16MnR异种金属的焊接

通过对Mone1400与16MnR的性能分析和试验。确定了焊接方法和焊接工艺参数。获得了优质的焊接接头，解决了Mone1400与16MnR异种金属焊接的技术难题，并成功地应用于化工设备的制造。     

Pd-Ag-Sn-In-Zn合金时效强化机制研究

通过硬度测试、X射线衍射（XRD）分析、扫描电镜（SEM）观察研究了Pd-Ag-Sn-In-Zn合金时效强化行为及相关的微观结构变化，从而很好地解释了该合金的时效强化机制。结果表明，时效前期合金硬度的增加与在晶界处形成中间过渡相有关。通过扫描电镜观察，可以清楚地看到基体相以及等温时效过程中在晶界处有类似珠光体的析出相。随着稳定第二相的长大，硬度持续下降。