Peripheral Artery Disease Is Associated with a Deficiency of Erythrocyte Membrane n-3 Polyunsaturated Fatty Acids

Population-based data suggest that individuals who consume large dietary amounts of n-3 polyunsaturated fatty acids (PUFA) have lower odds of peripheral artery disease (PAD); however, clinical studies examining n-3 PUFA levels in patients with PAD are sparse. The objective of this study is to compare erythrocyte membrane fatty acid (FA) content between patients with PAD and controls. We conducted a cross-sectional study of 179 vascular surgery outpatients (controls, 34; PAD, 145). A blood sample was drawn and the erythrocyte FA content was assayed using capillary gas chromatography. We calculated the ratio of the n-3 PUFA eicosapentaenoic acid (EPA) to the n-6 PUFA arachidonic acid (ARA) as well as the omega-3 index (O3I), a measure of erythrocyte content of the n-3 PUFA, EPA, and docosahexaenoic acid (DHA), expressed as a percentage of total erythrocyte FA. Compared with controls, patients with PAD smoked more and were more likely to have hypertension and hyperlipidemia (p < 0.05). Patients with PAD had a lower mean O3I (5.0 ± 1.7% vs 6.0 ± 1.6%, p < 0.001) and EPA:ARA ratio (0.04 ± 0.02 vs 0.05 ± 0.05, p < 0.001), but greater mean total saturated fats (39.5 ± 2.5% vs 38.5 ± 2.6%, p = 0.01). After adjusting for several patient characteristics, comorbidities, and medications, an absolute decrease of 1% in the O3I was associated with 39% greater odds of PAD (odds ratio [OR] 1.39, 95% confidence interval [CI] 1.03–1.86, and p = 0.03). PAD was associated with a deficiency of erythrocyte n-3 PUFA, a lower EPA:ARA ratio, and greater mean total saturated fats. These alterations in FA content may be involved in the pathogenesis or development of poor outcomes in PAD.     

A mode control model of counting and timing processes.

In Exp I, 10 male albino Norway rats initially learned a discrimination between a 2-cycle auditory signal of 2-sec duration and an 8-cycle auditory signal of 8-sec duration. In a number discrimination test, the number of cycles was varied, and the signal duration was held constant at an intermediate value. In a duration discrimination test, the signal duration was varied, and the number of cycles was held constant at an intermediate value. Ss were equally sensitive to a 4:1 ratio of counts (with duration controlled) and a 4:1 ratio of times (with number controlled). The point of subjective equality for the psychophysical functions that related response classification to signal value was near the geometric mean of the extreme values for both number and duration discriminations. Exp II demonstrated that methamphetamine (1.5 mg/kg, ip) shifted the psychophysical functions for both number and duration leftward by approximately 10%. Exp III demonstrated that the magnitude of cross-modal transfer from auditory to cutaneous signals was similar for number and duration. In Exp IV (6 Ss), the mapping of number onto duration demonstrated that a count was approximately equal to 200 msec. The psychophysical functions for number and duration were fit with a scalar expectancy model with the same parameter values for each attribute. It is concluded that the same internal mechanism is used for counting and timing. (33 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychologists in defense of the Federal Trade Commission.

The professional and economic challenges to psychologists posed by organized medicine have been stymied in the past by the Federal Trade Commission and by strict enforcement of the antitrust laws. Now that professionals' competition and consumer choice are being supported in the courts, the American Medical Association (AMA) is redoubling its efforts to retain a monopolistic hold on health care, hospital practice, and health insurance throughout the nation. Organized psychology, with the help of other professions and the Congress, has barely held the line against politically and economically stronger forces. The Association for the Advancement of Psychology and the American Psychological Association actively opposed the AMA's proposed legislation in 1981 and 1982 that would have allowed the AMA to circumvent valid law. The medical profession has actively worked to control all health care and deny psychologists hospital staff privileges, preventing group practice between physicians and psychologists, denying them health insurance reimbursement, and restricting psychological services to physician supervision. (5 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A clustering procedure for exploratory mining of vector time series

A two-step procedure is developed for the exploratory mining of real-valued vector (multivariate) time series using partition-based clustering methods. The proposed procedure was tested with model-generated data, multiple sensor-based process data, as well as simulation data. The test results indicate that the proposed procedure is quite effective in producing better clustering results than a hidden Markov model (HMM)-based clustering method if there is a priori knowledge about the number of clusters in the data. Two existing validity indices were tested and found ineffective in determining the actual number of clusters. Determining the appropriate number of clusters in the case that there is no a priori knowledge is a known unresolved research issue not only for our proposed procedure but also for the HMM-based clustering method and further development is necessary.     

Radiometric correction of multi-temporal Landsat data for characterization of early successional forest patterns in western Oregon

Detecting and characterizing continuous changes in early forest succession using multi-temporal satellite imagery requires atmospheric correction procedures that are both operationally reliable, and that result in comparable units (e.g., surface reflectance). This paper presents a comparison of five atmospheric correction methods (2 relative, 3 absolute) used to correct a nearly continuous 20-year Landsat TM/ETM+ image data set (19-images) covering western Oregon (path/row 46/29). In theory, full absolute correction of individual images in a time-series should effectively minimize atmospheric effects resulting in a series of images that appears more similar in spectral response than the same set of uncorrected images. Contradicting this theory, evidence is presented that demonstrates how absolute correction methods such as Second Simulation of the Satellite Signal in the Solar Spectrum (6 s), Modified Dense Dark Vegetation (MDDV), and Dark Object Subtraction (DOS) actually make images in a time-series somewhat less spectrally similar to one another. Since the development of meaningful spectral reflectance trajectories is more dependant on consistent measurement of surface reflectance rather than on accurate estimation of true surface reflectance, correction using image pairs is also tested. The relative methods tested are variants of an approach referred to as “absolute-normalization”, which matches images in a time-series to an atmospherically corrected reference image using pseudo-invariant features and reduced major axis (RMA) regression. An advantage of “absolute-normalization” is that all images in the time-series are converted to units of surface reflectance while simultaneously being corrected for atmospheric effects. Of the two relative correction methods used for “absolute-normalization”, the first employed an automated ordination algorithm called multivariate alteration detection (MAD) to statistically locate pseudo-invariant pixels between each subject and reference image, while the second used analyst selected pseudo-invariant features (PIF) common to the entire image set. Overall, relative correction employed in the “absolute-normalization” context produced the most consistent temporal reflectance response, with the automated MAD algorithm performing equally as well as the handpicked PIFs. Although both relative methods performed nearly equally in terms of observed errors, several reasons emerged for preferring the MAD algorithm. The paper concludes by demonstrating how “absolute-normalization” improves (i.e., reduces scatter in) spectral reflectance trajectory models used for characterizing patterns of early forest succession.     

A review of stochastic algorithms with continuous value function approximation and some new approximate policy iteration algorithms for multidimensional continuous applications

We review the literature on approximate dynamic programming, with the goal of better understanding the theory behind practical algorithms for solving dynamic programs with continuous and vector-valued states and actions and complex information processes. We build on the literature that has addressed the well-known problem of multidimensional (and possibly continuous) states, and the extensive literature on model-free dynamic programming, which also assumes that the expectation in Bellman’s equation cannot be computed. However, we point out complications that arise when the actions/controls are vector-valued and possibly continuous. We then describe some recent research by the authors on approximate policy iteration algorithms that offer convergence guarantees (with technical assumptions) for both parametric and nonparametric architectures for the value function.     

Particle Penetration through Inclined and L-Shaped Cracks

This paper presents a particle penetration model predicting particle penetration coefficient (Pp) through a narrow crack of arbitrary incline angles (θ). The objective was to simulate Pp for outdoor-to-indoor particle penetration for residential infiltration conditions. This model assumes laminar infiltration flow and considers particle deposition from both gravitational sedimentation and Brownian diffusion. For micron-sized particles, modeling results indicate that gravitational sedimentation is the major deposition mechanism. Pp increases monotonically with ∣θ∣ because effective particle sedimentation velocity (vs?cos?θ) decreases monotonically with ∣θ∣. For submicron-sized particles (0.1?μm), Brownian diffusion is the major particle deposition mechanism. Because Brownian diffusion is a nondirectional deposition mechanism, crack inclination did not affect Pp. This study applied this model to estimate Pp for L-shaped cracks, and validated modeling results with experiments. Experimental results indicated that inertial impaction and crack entrance cutoff effects were not significant particle deposition mechanisms for the test micron-sized particles. Gravitational sedimentation was the major deposition mechanism. An L-shaped crack can be simulated as the combination of horizontal and vertical sections. This model agreed reasonably with experimental results.